Abstract: Provided herein are compounds and compositions thereof for modulating S1P5. In some embodiments, the compounds and compositions are provided for treatment of neurological diseases.

Abstract: A counterweight assembly for counteracting vibrations or other forces in an appliance or machine includes a body and a funnel coupled to the body. The body includes an outer surface and an inner surface that defines an internal cavity that is adapted to receive a heavy aggregate material to form a counterweight. The funnel extends outwardly from the body and is adapted to deliver the heavy aggregate material to the internal cavity of the body.

Abstract: The techniques described herein relate to methods and apparatus for firearm safety mechanisms, visual safety indicators, and related techniques. A firearm includes a handle comprising one or more buttons disposed at least partially within a surface of the handle, such that the one or more buttons can be in contact with an operator's hand when the operator grasps the handle; a safety mechanism in mechanical communication with the trigger. The safety mechanism comprises: a first position that blocks actuation of the trigger; and a second position that does not block actuation of the trigger; and at least one processor configured to: upon determining an input code matches a stored code, transmits a signal to the safety mechanism to change the safety mechanism from the first position to the second position so that the firearm can be fired by the operator.

Abstract: A cleaning concentrate dispenser assembly, including: a housing sub-assembly; an energy source; an RFID reader; a level sensor; a controller (printed circuit board); a cleaning concentrate reservoir; a dispensing pump; and a cleaning concentrate output.

Abstract: The techniques described herein relate to methods and apparatus for firearm safety mechanisms, visual safety indicators, and related techniques. A firearm includes a handle comprising one or more buttons disposed at least partially within a surface of the handle, such that the one or more buttons can be in contact with an operator's hand when the operator grasps the handle; a safety mechanism in mechanical communication with the trigger. The safety mechanism comprises: a first position that blocks actuation of the trigger; and a second position that does not block actuation of the trigger; and at least one processor configured to: upon determining an input code matches a stored code, transmits a signal to the safety mechanism to change the safety mechanism from the first position to the second position so that the firearm can be fired by the operator.

Abstract: A cleaning solution including: a primary solvent; a secondary solvent, wherein the secondary solvent is at least partially miscible with the primary solvent; an oxidizing agent, wherein the oxidizing agent includes a peroxide; a chelating agent, wherein the chelating agent includes the structure of formula I: wherein R1-R4 are each independently selected from the group consisting of H; OH; and an alkyl, cycloalkyl, polycycloalkyl, heterocycloalkyl, aryl, alkaryl, aralkyl, alkoxy, alkanoyl, aroyl, alkenyl, alkyl-alkenyl, alcohol, ether, ketone, carboxylic acid, acid halide, acid anhydride, ester, and/or amide group containing approximately 1 to approximately 25 carbon atom(s); and wherein X1-X3 are each independently selected from the group consisting of O; S; and Se; a surfactant system, wherein the surfactant system includes a first anionic surfactant, a second anionic surfactant, a third anionic surfactant, and a fourth anionic surfactant; a pH modifier; and an optional amino acid.

Abstract: A cleaning solution including: a primary solvent; a secondary solvent, wherein the secondary solvent is at least partially miscible with the primary solvent; an oxidizing agent, wherein the oxidizing agent includes a peroxide; a chelating agent, wherein the chelating agent includes the structure of formula I: wherein R1-R4 are each independently selected from the group consisting of H; OH; and an alkyl, cycloalkyl, polycycloalkyl, heterocycloalkyl, aryl, alkaryl, aralkyl, alkoxy, alkanoyl, aroyl, alkenyl, alkyl-alkenyl, alcohol, ether, ketone, carboxylic acid, acid halide, acid anhydride, ester, and/or amide group containing approximately 1 to approximately 25 carbon atom(s); and wherein X1-X3 are each independently selected from the group consisting of O; S; and Se; a surfactant system, wherein the surfactant system includes a first anionic surfactant, a second anionic surfactant, a third anionic surfactant, and a fourth anionic surfactant; a pH modifier; and an optional amino acid.

Abstract: Techniques for live adaptive training in a production system are described. In an example, a training application executed on a workstation receives, based at least in part on an identifier of a user of the workstation, a training module and a trigger rule to present the training module. The training application exchanges, with a workstation application executed on the workstation, data about an event determined by the workstation application. The training application also determines a match between the trigger rule and the event. Based at least in part on the match, the training application initiates a presentation of the training module. In a further example, when the training module is presented, a transition rule may be used by the training application, based on an event from the workstation application, to determine a next training segment from the training module to present.

Abstract: A fishing system may have at least a fishing assembly with a handle axially aligned with a reel and a rod. The handle can have a hollow portion and a dexterity portion. The reel may be oriented relative to the handle to position a center of gravity of the fishing assembly in the handle. A fishing line may continuously extend from the reel through the hollow portion, atop the dexterity portion, and along the rod.

Abstract: Methods and systems for generating, facilitating, and providing pre-authorized return of delivered items in a logistics network. A shipper may designate one or more items for delivery to a recipient using a logistics provider. The shipper may designate the items as pre-authorized for return with the logistics provider. The pre-authorized return status may be established or determined based on a unique identifier associated with the shipper and/or an identifier associated with the item, which may be linked with shipper-designated return parameters. A recipient may initiate a return of an item with the logistics provider based on the pre-authorized return status. The unique identifier and/or item identifier may be used to determine details of the return and provide visibility to the shipper and/or to the recipient making the return. A recipient may initiate a return through a return portal.

Abstract: A Method and Apparatus for a User Configurable Docking System have been disclosed. In one embodiment of the invention, an electrical connector and a back support are adjustable by a user.

Abstract: An outside handle of a door of a vehicle that opens a latch, including a rotatable flap that sits flush against an outer panel of the vehicle in a closed position and that provides an opening to an interior of the handle in an open position, and a rotating lever behind the outer panel, movement of the lever opening the latch of the door. The handle is arranged such that the flap rotates to the open position when the door is unlocked and rotates to the closed position when the door is locked.

Abstract: A comfort recline seat including a seat back, a seat base, a pivotable connection point, a pivotable base structure, linkages, knuckle connectors may enable a seat base cushion and a seat back cushion to be manipulated to create a range of comfortable seating and bed-like surfaces. The seat may be configured such that the seat base cushion and the seat back cushion may be simultaneously adjusted together to reduce gaps or steps between the seat base cushion and the seat back cushion.

Abstract: A fruit harvester and methods of making and using the same are disclosed. The fruit harvester includes a frame and a collector connected to the frame. The collector includes a beater, one or more arms supporting the beater, one or more conveyor belts or moving beds configured to collect fruit dislodged from the plant(s) by the beater; and one or more augers configured to deposit the fruit into one or more bins held by the frame. The beater is configured to dislodge fruit and plant matter from one or more plants to which the fruit and plant matter are attached. The arm(s) are attached directly or indirectly to the frame. The conveyor belt(s) or moving bed(s) are configured to carry the fruit to the auger(s).

Abstract: A Method and Apparatus for a User Configurable Docking System have been disclosed. In one embodiment of the invention, a slidable electrical connector and a slidable back support are adjustable by a user.

Abstract: A fishing system may have at least a fishing assembly with a handle axially aligned with a reel and a rod. The handle can have a hollow portion and a dexterity portion. The reel may be oriented relative to the handle to position a center of gravity of the fishing assembly in the handle. A fishing line may continuously extend from the reel through the hollow portion, atop the dexterity portion, and along the rod.

Abstract: A comfort recline seat including a seat back, a seat base, a pivotable connection point, a pivotable base structure, linkages, knuckle connectors may enable a seat base cushion and a seat back cushion to be manipulated to create a range of comfortable seating and bed-like surfaces. The seat may be configured such that the seat base cushion and the seat back cushion may be simultaneously adjusted together to reduce gaps or steps between the seat base cushion and the seat back cushion.

Abstract: An outside handle of a door of a vehicle that opens a latch, including a rotatable flap that sits flush against an outer panel of the vehicle in a closed position and that provides an opening to an interior of the handle in an open position, and a rotating lever behind the outer panel, movement of the lever opening the latch of the door. The handle is arranged such that the flap rotates to the open position when the door is unlocked and rotates to the closed position when the door is locked.

Abstract: A side camera of a vehicle, including a camera housing rotatable in a first axis and a second axis each relative to an exterior surface of the vehicle, and a camera attached to the camera housing that captures image data. The camera is positioned in a plurality of positions by rotating the camera housing along the first axis and the second axis.

Abstract: A system for displaying information about a service. The system for displaying information about a service may include a database server that hosts a web page. The web page may display the digital version of information about the service. A QR code may be created to link a user to the web page. A user with a computer that has a QR code reading program may scan the QR code, which links to the web page displaying the digital version of the service onto the screen of the computer.