Patents by Inventor Patrick T. Johnson

Patrick T. Johnson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • STEERABLE RAIL DELIVERY SYSTEM
    Publication number: 20240081994
    Abstract: A steerable delivery system is provided for delivering a replacement heart valve to a native heart valve location. The steerable delivery system includes an outer sheath assembly having a capsule along a distal end portion for retaining the replacement heart valve in a compressed configuration. The capsule is constructed to provide both compression resistance and flexibility. The capsule may be formed with an outer polymer layer, a metal middle layer located on a radially inner surface of the outer polymer layer, and an inner liner located on a radially inner surface of the metal middle layer. A fluoroelastomer layer is provided for bonding the inner liner to the metal middle layer. The metal middle layer is preferably a metal hypotube.
    Type: Application
    Filed: November 21, 2023
    Publication date: March 14, 2024
    Inventors: Alexander H. Cooper, David Robert Landon, Kevin M. Stewart, Garrett Dallas Johnson, Glen T. Rabito, Tarannum Ishaq Gutierrez, Hiroshi Okabe, Ramon Aguilar, JR., Jesse Robert Edwards, Taylor Jacob Scheinblum, Patrick Chow, Julio Cesar Sanchez, Hieu Minh Luong
  • SELF-ASSEMBLING NANOPARTICLE DRUG DELIVERY SYSTEM
    Publication number: 20140010885
    Abstract: A self-assembling nanoparticle drug delivery system for the delivery of various bioactive agents including peptides, proteins, nucleic acids or synthetic chemical drugs is provided. The self-assembling nanoparticle drug delivery system described herein includes viral capsid proteins, such as Hepatitis B Virus core protein, encapsulating the bioactive agent, a lipid layer or lipid/cholesterol layer coat and targeting or facilitating molecules anchored in the lipid layer. A method for construction of the self-assembling nanoparticle drug delivery system is also provided.
    Type: Application
    Filed: January 18, 2012
    Publication date: January 9, 2014
    Inventors: Miguel de los Rios, Kenneth J. Oh, Timothy L. Bullock, Patrick T. Johnson, Jacek Ostrowski
  • CHIMERIC THERAPEUTICS, COMPOSITIONS, AND METHODS FOR USING SAME
    Publication number: 20110293725
    Abstract: Chimeric therapeutics are disclosed that include a modified viral core protein and a nucleic acid bound to the modified viral core protein. The nucleic acid may be substantially homologous to a specific gene target. In some embodiments, the nucleic acid bound to the modified viral core protein is substantially non-immunogenic. Also disclosed are particles and compositions that include disclosec chimeric therapeutics.
    Type: Application
    Filed: April 8, 2011
    Publication date: December 1, 2011
    Inventors: Miguel de los Rios, John Mendlein, Timothy L. Bullock, Kenneth J. Oh, Patrick T. Johnson, Jacek Ostrowski, Stephanie de los Rios
  • CHIMERIC THERAPEUTICS, COMPOSITIONS, AND METHODS FOR USING SAME
    Publication number: 20110293726
    Abstract: Chimeric therapeutics are disclosed that include a modified viral core protein and a nucleic acid bound to the modified viral core protein. The nucleic acid may be substantially homologous to a specific gene target. In some embodiments, the nucleic acid bound to the modified viral core protein is substantially non-immunogenic. Also disclosed are particles and compositions that include disclosed chimeric therapeutics.
    Type: Application
    Filed: April 8, 2011
    Publication date: December 1, 2011
    Inventors: Miguel de los Rios, John Mendlein, Timothy L. Bullock, Kenneth J. Oh, Patrick T. Johnson, Jacek Ostrowski, Stephanie de los Rios
  • CHIMERIC THERAPEUTICS, COMPOSITIONS, AND METHODS FOR USING SAME
    Publication number: 20110293727
    Abstract: Chimeric therapeutics are disclosed that include a modified viral core protein and a nucleic acid bound to the modified viral core protein. The nucleic acid may be substantially homologous to a specific gene target. In some embodiments, the nucleic acid bound to the modified viral core protein is substantially non-immunogenic. Also disclosed are particles and compositions that include disclosec chimeric therapeutics.
    Type: Application
    Filed: April 8, 2011
    Publication date: December 1, 2011
    Inventors: Miguel de los Rios, John Mendlein, Timothy L. Bullock, Kenneth J. Oh, Patrick T. Johnson, Jacek Ostrowski, Stephanie de los Rios
  • Compositions and methods for treating B-cell malignancies
    Patent number: 8067011
    Abstract: The present invention provides a targeted multi-layered drug delivery system for the delivery of cytotoxic agents to B-cells.
    Type: Grant
    Filed: April 9, 2007
    Date of Patent: November 29, 2011
    Assignee: Chimeros, Inc.
    Inventors: Claude Geoffrey Davis, Miguel A. de los Rios, Kenneth J. Oh, Timothy L. Bullock, Patrick T. Johnson, Jacek Ostrowski
  • Self-assembling nanoparticle drug delivery system
    Publication number: 20090226525
    Abstract: A self-assembling nanoparticle drug delivery system for the delivery of various bioactive agents including peptides, proteins, nucleic acids or synthetic chemical drugs is provided. The self-assembling nanoparticle drug delivery system described herein includes viral capsid proteins, such as Hepatitis B Virus core protein, encapsulating the bioactive agent, a lipid layer or lipid/cholesterol layer coat and targeting or facilitating molecules anchored in the lipid layer. A method for construction of the self-assembling nanoparticle drug delivery system is also provided.
    Type: Application
    Filed: April 9, 2008
    Publication date: September 10, 2009
    Inventors: Miguel de los Rios, Kenneth J. Oh, Timothy L. Bullock, Patrick T. Johnson, Jacek Ostrowski