Patents by Inventor Patrick Theodoor Christian Van Den Bogaard

Patrick Theodoor Christian Van Den Bogaard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the detection and characterization of a toxinogenic strain
    Patent number: 10876174
    Abstract: The invention relates to a cartridge for the detection and characterization of a toxinogenic Clostridium difficile strain in a sample, wherein the following steps are performed, (i) a sample is provided for, (ii) in a multiplex PCR assay, (iii) the sample is analyzed with respect to the presence or absence of the cytotoxin tcdB gene, (iv) the sample is analyzed with respect to the presence or absence of one or more of the following deletions in the tcdC gene: (a) an 18 bp deletion in SEQ ID NO. 1 from nucleotide 330 to nucleotide 347, (b) a 36 bp deletion in SEQ ID NO. 1 from nucleotide 301 to nucleotide 336, (c) a 39 bp deletion in SEQ ID NO. 1 from nucleotide 341 to nucleotide 370, (d) a 54 bp deletion in SEQ ID NO. 1 from nucleotide 313 to nucleotide 366 and (e) a single nucleotide deletion at position 117 of SEQ ID NO. 1. The invention also relates to respective kits and primers and probes.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: December 29, 2020
    Assignee: Koninklijke Philips N.V.
    Inventors: Patrick Theodoor Christian van den Bogaard, Astrid Elisabeth Visser
  • METHOD FOR THE DETECTION AND CHARACTERIZATION OF A TOXINOGENIC CLOSTRIDIUM DIFFICILE STRAIN
    Publication number: 20180237827
    Abstract: The invention relates to a cartridge for the detection and characterization of a toxinogenic Clostridium difficile strain in a sample, wherein the following steps are performed, (i) a sample is provided for, (ii) in a multiplex PCR assay, (iii) the sample is analyzed with respect to the presence or absence of the cytotoxin tcdB gene, (iv) the sample is analyzed with respect to the presence or absence of one or more of the following deletions in the tcdC gene: (a) an 18 bp deletion in SEQ ID NO. 1 from nucleotide 330 to nucleotide 347, (b) a 36 bp deletion in SEQ ID NO. 1 from nucleotide 301 to nucleotide 336, (c) a 39 bp deletion in SEQ ID NO. 1 from nucleotide 341 to nucleotide 370, (d) a 54 bp deletion in SEQ ID NO. 1 from nucleotide 313 to nucleotide 366 and (e) a single nucleotide deletion at position 117 of SEQ ID NO. 1. The invention also relates to respective kits and primers and probes.
    Type: Application
    Filed: June 8, 2017
    Publication date: August 23, 2018
    Inventors: Patrick Theodoor Christian van den Bogaard, Astrid Elisabeth Visser
  • METHOD FOR THE DETECTION AND CHARACTERIZATION OF A TOXINOGENIC CLOSTRIDIUM DIFFICILE STRAIN
    Publication number: 20120028819
    Abstract: The invention relates to a method for the detection and characterization of a toxinogenic Clostridium difficile strain in a sample, wherein the following steps are performed, (i) a sample is provided for, (ii) in a multiplex PCR assay, (iii) the sample is analyzed with respect to the presence or absence of the cytotoxin tcdB gene, (iv) the sample is analyzed with respect to the presence or absence of one or more of the following deletions in the tcdC gene: (a) an 18 bp deletion in SEQ ID NO. 1 from nucleotide 330 to nucleotide 347, (b) a 36 bp deletion in SEQ ID NO. 1 from nucleotide (301) to nucleotide (336), (c) a 39 bp deletion in SEQ ID NO. 1 from nucleotide (341) to nucleotide (370), (d) a 54 bp deletion in SEQ ID NO. 1 from nucleotide (313) to nucleotide (366) and (e) a single nucleotide deletion at position 117 of SEQ ID NO. 1. The invention also relates to respective kits and primers and probes.
    Type: Application
    Filed: March 31, 2010
    Publication date: February 2, 2012
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Patrick Theodoor Christian Van Den Bogaard, Astrid Elisabeth Visser