Patents by Inventor Patrick Thomas Gunning

Patrick Thomas Gunning has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sensors for detection of negatively charged phosphate-containing membranes and membrane components
    Patent number: 11851410
    Abstract: This application relates to a method of detecting negatively charged phosphate-containing membranes and membrane components, such as in cell membranes or artificial lipid vesicles, and its use, for example, in detecting apoptosis and bacterial infection.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: December 26, 2023
    Assignee: The Governing Council of the University of Toronto
    Inventors: Patrick Thomas Gunning, Dziyana Kraskouskaya, Aaron Cabral, Bronte Murcar-Evans, Krimo Toutah, Elvin De Araujo
  • STAT INIHIBITORY COMPOUNDS AND COMPOSITIONS
    Publication number: 20230265055
    Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for the inhibition of Signal Transducer and Activator of Transcription 5a and 5b (STAT5). Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as, for example, breast cancer, hematological cancer, and pancreatic cancer.
    Type: Application
    Filed: September 3, 2021
    Publication date: August 24, 2023
    Inventors: Roman FLECK, John PROUDFOOT, Jeff OMEARA, Patrick Thomas GUNNING, Ahmed Magdy ALI, David Alexander ROSA, Angel Sampedro PALERM, Alla DARWISH, Alford Antoine JOHN
  • STAT INHIBITORY COMPOUNDS AND COMPOSITIONS
    Publication number: 20230159445
    Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for the inhibition of Signal Transducer and Activator of Transcription 5a and 5b (STAT5). Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as, for example, breast cancer and pancreatic cancer.
    Type: Application
    Filed: March 5, 2021
    Publication date: May 25, 2023
    Inventors: Roman FLECK, John PROUDFOOT, Jeff OMEARA, Krishna Kumar GNANASEKARAN, Patrick Thomas GUNNING, Alford Antoine JOHN, Angel Sampedro PALERM, Alla DARWISH, Dziyana KRASKOUSKAYA, Ahmed Magdy Ahmed Mohamed ALI
  • HETEROCYCLE CONTAINING STAT INHIBITORS AND COMPOSITIONS
    Publication number: 20230150946
    Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for the inhibition of Signal Transducer and Activator of Transcription 5a and 5b (STAT5). Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as, for example, breast cancer and pancreatic cancer.
    Type: Application
    Filed: March 5, 2021
    Publication date: May 18, 2023
    Inventors: Roman FLECK, John PROUDFOOT, Krishna Kumar GNANASEKARAN, Patrick Thomas GUNNING, Alford Antoine JOHN, Angel Sampedro PALERM, Alla DARWISH, Dziyana KRASKOUSKAYA
  • ALPHA SUBSTITUTED STAT INHIBITORS AND COMPOSITIONS THEREOF
    Publication number: 20230137956
    Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for the inhibition of Signal Transducer and Activator of Transcription 5a and 5b (STAT5). Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as, for example, breast cancer and pancreatic cancer.
    Type: Application
    Filed: March 5, 2021
    Publication date: May 4, 2023
    Inventors: Roman FLECK, John PROUDFOOT, Jeff OMEARA, Patrick Thomas GUNNING, Angel Sampedro PALERM, Alla DARWISH, Dziyana KRASKOUSKAYA
  • CANNABINOID DERIVATIVES
    Publication number: 20230024212
    Abstract: The present application discloses a compound of formula (I), compositions comprising said compound, and a method of using said compound as a cannabinoid receptor ligand in the treatment or prevention of diseases associated with a cannabinoid receptor, such as, CB1, CB2, 5HT1A, 5HT2A, GPR18, GPR119, TRPV1, TPRV2, PPAR? or a ?-opioid receptor.
    Type: Application
    Filed: November 27, 2020
    Publication date: January 26, 2023
    Inventors: PATRICK THOMAS GUNNING, JEFFREY ALAN OMEARA, QUANG HUY TO
  • CANNABINOID DERIVATIVES
    Publication number: 20220259221
    Abstract: This disclosure relates to a cannabinoid derivative of formula (I), pharmaceutical composition thereof, and method of treating or preventing diseases associated with cannabinoid receptor in a subject in need thereof, wherein the cannabinoid receptor is one or more of CB1, CB2, 5HT1A, 5HT2A, GPR18, GPR55, GPR119, TRPV1, TRPV2, PPAR? or a ?-opioid receptor.
    Type: Application
    Filed: July 10, 2020
    Publication date: August 18, 2022
    Inventors: JEFFREY ALAN OMEARA, QUANG HUY TO, PATRICK THOMAS GUNNING
  • NEW SALICYLIC ACID DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, COMPOSITION THEREOF AND METHOD OF USE THEREOF
    Publication number: 20220089531
    Abstract: The present invention relates to novel compounds, compositions containing same and methods for inhibiting STAT3 and/or STAT5 activity or for the treatment of a cell proliferative disorder such as a cancer using a compound of formula I or a pharmaceutically acceptable salt, solvate or hydrate thereof, wherein R and R1, different, are selected from the group consisting of wherein when one of R and R1 is a —H, the other of R and R1 is a cyclopentyl moiety, R2 is a benzyl substituted with 1-5 halogens, preferably —Cl or —F, and R3 is selected from the group consisting of —H or —OH.
    Type: Application
    Filed: December 20, 2019
    Publication date: March 24, 2022
    Inventors: Patrick Thomas Gunning, Siawash Ahmar, David Rosa, Gary Tin, Mulu Geletu, Ji Sung Park, Elvin D. De Araujo
  • Excimer forming compounds
    Patent number: 10889554
    Abstract: The present application is directed to excimer forming compounds of Formula I: W—V—[Y]n wherein W is an excimer forming fluorophore, V is a linker moiety, Y is a metal ion coordinating moiety and n is 1, 2 or 3. In particular, the application is directed to excimer forming compounds for the detection of proximally phosphorylated sites including those found on polypeptides, proteins, pyrophosphate and RNA, for example in aqueous solution, polyacrylamide gels blotting membranes, solid-support assays and in cell culture samples.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: January 12, 2021
    Assignee: The Governing Council of the University of Toronto
    Inventors: Patrick Thomas Gunning, Dziyana Kraskouskaya
  • PENTAFLUOROPHENYL SULFONAMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF
    Publication number: 20200277268
    Abstract: The present application relates to sulfonamide containing compounds of Formulae (I) and (II) and compositions containing said compounds effective in the treatment of cell proliferative disorders, in particular cancer, and various methods of use thereof.
    Type: Application
    Filed: September 21, 2018
    Publication date: September 3, 2020
    Applicant: Dalriada Therapeutics Inc.
    Inventors: Patrick Thomas Gunning, Ji Sung Park, Siawash Ahmar, David Alexander Rosa, Dziyana Kraskouskaya, David Bakhshinyan, Sheila Singh, Chitra Venugopal, Angelika Berger-Becvar, Mulu Geletu-Heye, Mariya Bogatchenko, Elvin De Araujo, Diana Sina
  • SENSORS FOR DETECTION OF NEGATIVELY CHARGED PHOSPHATE-CONTAINING MEMBRANES AND MEMBRANE COMPONENTS
    Publication number: 20200270218
    Abstract: This application relates to a method of detecting negatively charged phosphate-containing membranes and membrane components, such as in cell membranes or artificial lipid vesicles, and its use, for example, in detecting apoptosis and bacterial infection.
    Type: Application
    Filed: October 1, 2018
    Publication date: August 27, 2020
    Inventors: Patrick Thomas Gunning, Dzlyana Kraskouskaya, Aaron Cabral, Bronte Murcar-Evans, Krlmo Toutah, Elvln De Araujo
  • Sulfonamide compounds and their use as STAT5 inhibitors
    Patent number: 10519107
    Abstract: The present disclosure relates to compounds having the Formula (Formula (I)) which are inhibitors of STAT5.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: December 31, 2019
    Assignee: The Governing Council of the University of Toronto
    Inventors: Patrick Thomas Gunning, Abbarna A. Cumaraswamy, Andrew Martin Lewis, Mulu Geletu-Heye
  • SALICYLIC ACID DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, COMPOSITION THEREOF AND METHOD OF USE THEREOF
    Publication number: 20190382422
    Abstract: The present invention relates to novel compounds, compositions containing same and methods for inhibiting STAT3 and/or STAT5 activity or for the treatment of a STAT3 or STAT5-dependent cancer using said compounds; or a pharmaceutically acceptable salt, solvate or prodrug thereof.
    Type: Application
    Filed: June 25, 2019
    Publication date: December 19, 2019
    Inventors: Patrick Thomas Gunning, Sina Haftchenary, Brent David George Page, Samuel Weiss, Hema Artee Luchman, Melissa L. Fishel
  • Salicylic acid derivatives, pharmaceutically acceptable salt thereof, composition thereof and method of use thereof
    Patent number: 10377780
    Abstract: The present invention relates to novel compounds, compositions containing same and methods for inhibiting STAT3 and/or STAT5 activity or for the treatment of a STAT3 or STAT5-dependent cancer using said compounds; or a pharmaceutically acceptable salt, solvate or prodrug thereof.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: August 13, 2019
    Assignees: The Governing Council of the University of Toronto, UTI Limited Partnership, Indiana University Research and Technology Corporation
    Inventors: Patrick Thomas Gunning, Sina Haftchenary, Brent David George Page, Samuel Weiss, Hema Artee Luchman, Melissa L. Fishel
  • UBA5 inhibitors
    Patent number: 10077284
    Abstract: The present disclosure relates to compounds of the Formula (I), which are UBA5 inhibitors.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: September 18, 2018
    Assignee: The Governing Council of The University of Toronto
    Inventors: Patrick Thomas Gunning, Sara R. Da Silva, Stacey-Lynn Paiva, Julie Lynn Lukkarila
  • SALICYLIC ACID DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, COMPOSITION THEREOF AND METHOD OF USE THEREOF
    Publication number: 20170267704
    Abstract: The present invention relates to novel compounds, compositions containing same and methods for inhibiting STAT3 and/or STAT5 activity or for the treatment of a STAT3 or STAT5-dependent cancer using said compounds; or a pharmaceutically acceptable salt, solvate or prodrug thereof.
    Type: Application
    Filed: March 30, 2017
    Publication date: September 21, 2017
    Applicants: The Governing Council of the University of Toronto, UTI Limited Partnership, Indiana University Research and Technology Corporation
    Inventors: Patrick Thomas Gunning, Sina Haftchenary, Brent David George Page, Samuel Weiss, Hema Artee Luchman, Melissa L. Fishel
  • Salicylic acid derivatives, pharmaceutically acceptable salt thereof, composition thereof and method of use thereof
    Patent number: 9650399
    Abstract: The present invention relates to novel compounds, compositions containing same and methods for inhibiting STAT3 and/or STAT5 activity or for the treatment of a STAT3 or STAT5-dependent cancer using said compounds; or a pharmaceutically acceptable salt, solvate or prodrug thereof.
    Type: Grant
    Filed: May 24, 2013
    Date of Patent: May 16, 2017
    Assignees: The Governing Council of the University of Toronto, UTI Limited Partnership, Indiana University Research and Technology Corporation
    Inventors: Patrick Thomas Gunning, Sina Haftchenary, Brent David George Page, Samuel Weiss, Hema Artee Luchman, Melissa L. Fishel
  • UBA5 INHIBITORS
    Publication number: 20170107247
    Abstract: The present disclosure relates to compounds of the Formula (I), which are UBA5 inhibitors.
    Type: Application
    Filed: May 29, 2015
    Publication date: April 20, 2017
    Inventors: Patrick Thomas Gunning, Sara R. Da Silva, Stacey-Lynn Paiva, Julie Lynn Lukkarila
  • SULFONAMIDE COMPOUNDS AND THEIR USE AS STAT5 INHIBITORS
    Publication number: 20170101369
    Abstract: The present disclosure relates to compounds having the Formula (Formula (I)) which are inhibitors of STAT5.
    Type: Application
    Filed: May 29, 2015
    Publication date: April 13, 2017
    Inventors: Patrick Thomas Gunning, Abbarna A. Cumaraswamy, Andrew Martin Lewis, Mulu Geletu-Heye
  • EXCIMER FORMING COMPOUNDS
    Publication number: 20160304473
    Abstract: The present application is directed to excimer forming compounds of Formula I: W—V—[Y]n wherein W is an excimer forming fluorophore, V is a linker moiety, Y is a metal ion coordinating moiety and n is 1, 2 or 3. In particular, the application is directed to excimer forming compounds for the detection of proximally phosphorylated sites including those found on polypeptides, proteins, pyrophosphate and RNA, for example in aqueous solution, polyacrylamide gels blotting membranes, solid-support assays and in cell culture samples.
    Type: Application
    Filed: December 19, 2014
    Publication date: October 20, 2016
    Inventors: Patrick Thomas Gunning, Dziyana Kraskouskaya