Abstract: The present invention relates to a functionalized metallic implant comprising a metallic substrate having a covalently bound organic acid layer and a polymeric coating covalently attached thereto. The polymeric coating includes cationic, anionic, zwitterionic, and/or hydrophobic functional groups configured to associate therapeutic agents via electrostatic and/or hydrophobic interactions. Therapeutic agent release or availability is controlled as a function of surface charge, hydrophobicity, or both, enabling localized and sustained delivery in response to local biological conditions. In certain embodiments, the coating provides antibacterial activity through contact-based membrane disruption or inhibition of bacterial adhesion. In further embodiments, zwitterionic coatings exhibit pH-responsive charge behavior enabling selective loading and release of therapeutic agents.

Abstract: A device for attaching soft tissue to a prosthetic implant. The device includes a body that includes a frame and a porous section disposed within the frame, wherein the porous section permits the passage of body fluids therethrough to encourage the healing of the soft tissue as well as the growth of soft tissue into and through the porous section.

Abstract: A device for attaching soft tissue to a prosthetic implant. The device includes a body that includes a frame and a porous section disposed within the frame, wherein the porous section permits the passage of body fluids therethrough to encourage the healing of the soft tissue as well as the growth of soft tissue into and through the porous section.

Abstract: A device for attaching soft tissue to a prosthetic implant. The device includes a body that includes a frame and a porous section disposed within the frame, wherein the porous section permits the passage of body fluids therethrough to encourage the healing of the soft tissue as well as the growth of soft tissue into and through the porous section.

Abstract: A device for attaching soft tissue to a prosthetic implant. The device includes a body that includes a frame and a porous section disposed within the frame, wherein the porous section permits the passage of body fluids therethrough to encourage the healing of the soft tissue as well as the growth of soft tissue into and through the porous section.

Abstract: A device for attaching soft tissue to a prosthetic implant. The device includes a body that includes a frame and a porous section disposed within the frame, wherein the porous section permits the passage of body fluids therethrough to encourage the healing of the soft tissue as well as the growth of soft tissue into and through the porous section.