Abstract: A method for calibrating a sensor of a sensor system. A plurality of sensors structurally identical to the sensor of the sensor system and a general sensor model are provided. An inner optimization step is subsequently carried out for each of the structurally identical sensors. During the inner optimization step, a sensor-specific sensor model is initialized using the general sensor model and a sensor-specific model parameter is subsequently optimized based on measured data of the sensor. The sensor-specific sensor model is adapted with the aid of the sensor-specific model parameter. An outer optimization step is then carried out. In this step, the sensor-specific sensor models adapted for each sensor are used in order to optimize the general sensor model. The general sensor model is stored in a memory of the sensor system.

Abstract: An optical gyroscope assembly for measuring a rotation rate. The optical gyroscope assembly includes a first multimode interferometer with an input for receiving light and two outputs, each connected to a second light guide; a ring resonator on each of the second light guides; a second multimode interferometer with two inputs, each connected to one of the second light guides, and two outputs, each connected to a third light guide; and a third multimode interferometer with two inputs, each connected to one of the third light guides, and two outputs, each connected to a fourth light guide.

Abstract: An optical rotation rate sensor. The sensor includes a laser light source for generating weak light pulses, optically connected to a photonic waveguide, optically connected to a first interference coupler that includes a first input and two first outputs, optically connected to a second interference coupler that includes two second inputs and two second outputs, optically connected to at least one first sensor waveguide for showing the Sagnac effect, optically connected to a third interference coupler that includes two third inputs and two third outputs, optically connected to two photodetectors, the photonic waveguide, the first interference coupler, the second interference coupler, the third interference coupler and the sensor waveguide being integrated on a shared substrate.

Abstract: A method of preparing a pharmaceutical product comprises the steps of (a) providing a neat active pharmaceutical ingredient (API) complying with at least five of the following parameters determined by using a FT4 powder rheometer: (i) specific basic flow energy of at most 60 mJ/g; (ii) stability index of 0.75 to 1.25; (iii) specific energy of at most 10 mJ/g; (iv) major principle stress at 15 kPa of at most 40; (v) flow function at 15 kPa of at least 1.3; (vi) consolidated bulk density at 15 kPa of at least 0.26 g/mL; (vii) compressibility of at most 47%; and (viii) wall friction angle of at most 40°; (b) dispensing the neat API of step (a) into a bottom part of a pharmaceutical carrier using a vacuum assisted metering and filling device; and (c) encapsulating the bottom part, thereby producing a pharmaceutical product.

Abstract: A formulation for injection moulding of a pharmaceutical carrier comprising 27-85% (w/w) of polyvinyl alcohol, and 10-60% (w/w) of a disintegration aid selected from maize starch, wheat starch, and combinations thereof; and optionally one or more excipients.

Abstract: The present invention relates to methods of preparing pharmaceutical products, involving filling active pharmaceutical ingredient powders into pharmaceutical carriers with a vacuum assisted metering and filling device. The methods disclosed herein can be used in a continuous process, such as in a high-throughput process for producing a pharmaceutical product. The present invention further relates to a particular quality of the neat active pharmaceutical ingredient (API) HDM201, i.e. siremadlin, present as succinic acid co-crystal, which can be used in the methods of preparation of the present invention.

Abstract: A method of preparing a pharmaceutical product comprises the steps of (a) providing a neat active pharmaceutical ingredient (API) complying with at least five of the following parameters determined by using a FT4 powder rheometer: (i) specific basic flow energy of at most 60 mJ/g; (ii) stability index of 0.75 to 1.25; (iii) specific energy of at most 10 mJ/g; (iv) major principle stress at 15 kPa of at most 40; (v) flow function at 15 kPa of at least 1.3; (vi) consolidated bulk density at 15 kPa of at least 0.26 g/mL; (vii) compressibility of at most 47%; and (viii) wall friction angle of at most 40°; (b) dispensing the neat API of step (a) into a bottom part of a pharmaceutical carrier using a vacuum assisted metering and filling device; and (c) encapsulating the bottom part, thereby producing a pharmaceutical product.

Abstract: A formulation for injection molding of a pharmaceutical carrier comprises 43.5-97% (w/w) of one or more polyethylene oxide polymer having a weight average molecular weight of MW 94,000-188,000; and optionally one or more excipients.

Abstract: A pharmaceutical carrier (20) comprises a lid part (22) and a bottom part (24), wherein at least one of the lid part (22) and the bottom part (24) has a first wall section (26, 30) with a thickness of 180-250 ?m, preferably 185-225 ?m, even more preferably 190-220 ?m, and most preferably about 215 ?m, and a second wall section (28, 32) with a thickness of 350-450 ?m, preferably 375-425 ?m, more preferably 390-410 ?m, and most preferably about 400 ?m. The first wall section (26) of the lid part (22) defines an entire top portion of the lid part (22). Alternatively or additionally thereto, the first wall section (30) of the bottom part (24) defines an entire bottom portion of the bottom part (24).