Patents by Inventor Patrick Trojer

Patrick Trojer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EZH2 INHIBITION THERAPIES FOR THE TREATMENT OF ANDROGEN RECEPTOR MUTATED PROSTATE CANCERS
    Publication number: 20230414593
    Abstract: Provided herein are methods of treating prostate cancer having at least one pathogenic AR mutation using 7-chloro-2-(4-(3-methoxyazetidin-1-yl)cyclohexyl)-2,4-dimethyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3- yl)methyl)benzo[d][1,3]dioxole-5-carboxamide, or a pharmaceutically acceptable salt thereof, alone or in combination with a therapeutically effective amount of an androgen receptor signaling inhibitor (ARSI) such as enzalutamide.
    Type: Application
    Filed: November 18, 2021
    Publication date: December 28, 2023
    Inventors: William D. Bradley, Jike Cui, Kaiming Sun, Patrick Trojer, Jing Wang, Rentian Wu
  • EZH2 INHIBITOR-INDUCED GENE EXPRESSION
    Publication number: 20210161883
    Abstract: Provided herein are methods of treating subjects characterized as having a gene signature that is indicative of EZH2-inhibitor response, methods for determining said gene signature, and methods of determining which subjects may be responsive to cancer treatments based on said gene signature.
    Type: Application
    Filed: July 10, 2018
    Publication date: June 3, 2021
    Inventors: William D. Bradley, Barbara M. Bryant, Patrick Trojer
  • COMBINATIONS OF EZH2 INHIBITORS WITH FURTHER AGENTS FOR USE IN THE TREATMENT OF CANCER
    Publication number: 20200093815
    Abstract: Provided herein are methods of treating cancer using an effective amount of an EZH2 inhibitor and an effective amount of a second agent. Also provided are compositions comprising an EZH2 inhibitor and an effective amount of a second agent.
    Type: Application
    Filed: July 27, 2016
    Publication date: March 26, 2020
    Inventors: Shilpi Arora, Srividya Balasubramanian, William D Bradley, Patrick Trojer
  • MARKERS FOR PERSONALIZED CANCER TREATMENT WITH LSD1 INHIBITORS
    Publication number: 20200069677
    Abstract: Provided herein are methods of treating cancers characterized by a high expression of GFIIB, comprising administering a therapeutically effective amount of a KDMIA inhibitor.
    Type: Application
    Filed: December 8, 2017
    Publication date: March 5, 2020
    Applicants: Constellation Pharmaceuticals, Inc., Constellation Pharmaceuticals, Inc.
    Inventors: John McGrath, Patrick Trojer
  • COMBINATION THERAPIES FOR MODULATION OF HISTONE METHYL MODIFYING ENZYMES
    Publication number: 20180214519
    Abstract: Provided herein are pharmaceutical compositions comprising an EZH2 inhibitor and a type I interferon, processes for preparing such pharmaceutical compositions, and uses thereof in modulating the activity of histone methyl modifying enzymes.
    Type: Application
    Filed: July 24, 2015
    Publication date: August 2, 2018
    Inventors: Shilpi Arora, Srividya Balasubramanian, William D. Bradley, Patrick Trojer
  • METHODS OF TREATING CANCER AND PREVENTING CANCER DRUG RESISTANCE
    Publication number: 20160143910
    Abstract: Provided herein are methods of treating and/or preventing cancer drug resistance using antagonists of KDM5.
    Type: Application
    Filed: March 14, 2014
    Publication date: May 26, 2016
    Applicants: CONSTELLATION PHARMACEUTICALS, INC., GENENTECH, INC.
    Inventors: Shilpi Arora, Michael Robert Costa, Ted Lau, Patrick Trojer, Brian K. Albrecht, Shane Buker, Marie Classon, Victor S. Gehling, Jean-Christophe Harmange, Erica L. Jackson, Jun Liang, Heidi Phillips, Peter Sandy, Jeffrey Settleman, Jean-Philippe Stephan
  • AGENTS FOR STIMULATING ACTIVITY OF METHYL MODIFYING ENZYMES AND METHODS OF USE THEREOF
    Publication number: 20110021362
    Abstract: Agents for stimulating activity of methyl modifying enzymes and methods of using the enzymes in assays to identify enzyme modulators are provided herein.
    Type: Application
    Filed: July 20, 2010
    Publication date: January 27, 2011
    Applicant: CONSTELLATION PHARMACEUTICALS
    Inventors: Patrick Trojer, Fei Lan
  • SELECTIVE INHIBITORS FOR TRANSFERASES
    Publication number: 20090306201
    Abstract: A pharmaceutical composition comprising a compound of formula I or II and a pharmaceutically acceptable carrier. Methods for treating a proliferative disorder mediated by a methyl transferase comprising administering an anti-proliferative effective amount of the compound of formula I or II are also presented.
    Type: Application
    Filed: June 15, 2007
    Publication date: December 10, 2009
    Applicant: University of Medicine and Dentistry of New Jersey
    Inventors: Danny Reinberg, Patrick Trojer, Gianluca Sbardella
  • High throughput screening assay for histone modifying enzyme modulators
    Publication number: 20080070257
    Abstract: The present invention provides a general method for identify agents that modulate the activity of histone modifying enzymes, such as an acetylase, deacetylase, methyltransferase, demethylase, kinase, etc. The assay the of invention employs reconstituted, immobilized nucleosomes and fluorescence-based assays, such as fluorescence-based immunoassays, scintillation proximity assays, or FRET assays to determine whether the agent modulates the activity of the histone modifying enzymes.
    Type: Application
    Filed: September 13, 2007
    Publication date: March 20, 2008
    Inventors: Patrick Trojer, Danny Reinberg