Patents by Inventor Patrick W. Gray

Patrick W. Gray has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant methods of making gamma interferon compositions
    Patent number: 5595888
    Abstract: Provided are methods for the production of mixtures of interferon (IFN)-.gamma. polypeptides. The methods employ a single species of IFN-.sub..gamma. DNA having codons for Met-Gln and for residues 2-143 of the mature human IFN-.sub..gamma. amino acid sequence. Expression of such DNA in a suitable recombinant host cell affords a mixture of polypeptides having N-terminal Met-Gln, H-Gln, or H-pyroglutamate residues and C-termini at Arg.sup.139, Ser.sup.142, or Gln.sup.143 of the mature IFN-.sub..gamma. sequence. The polypeptides so produced exhibit the antiviral and antiproliferative activities as well as the acid lability characteristic of native human IFN-.sub..gamma..
    Type: Grant
    Filed: March 24, 1994
    Date of Patent: January 21, 1997
    Assignee: Genentech, Inc.
    Inventors: Patrick W. Gray, Ernst H. Rinderknecht
  • G protein-coupled receptor kinase GRK6
    Patent number: 5591618
    Abstract: The present invention provides purified and isolated polynucleotide sequences encoding the novel G protein-coupled receptor kinase designated GRK6. Also provided by the invention are methods and materials for the recombinant production of GRK6 enzyme and methods for identifying compounds which modulate the protein kinase activity of GRK6.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: January 7, 1997
    Assignee: ICOS Corporation
    Inventors: David Chantry, Patrick W. Gray, Merl F. Hoekstra
  • Recombinant DES-CYS-TYR-CYS human immune interferon
    Patent number: 5582824
    Abstract: Disclosed is a complete description of the preparation of novel, recombinant human immune interferon and des-CYS-TYR-CYS recombinant human immune interferon via recombinant DNA techniques utilizing any of an assortment of expression vectors and host cultures. The human immune (gamma) interferon (IFN-.gamma.), is isolated and characterized in terms of DNA and amino acid sequences, physical attributes and biological activity.
    Type: Grant
    Filed: November 12, 1993
    Date of Patent: December 10, 1996
    Assignee: Genentech, Inc.
    Inventors: David V. Goeddel, Patrick W. Gray
  • Recombinant gamma interferons having enhanced stability and methods therefor
    Patent number: 5574137
    Abstract: The present invention relates to novel, stable recombinant gamma interferons exhibiting in greater or less degree the antiviral and antiproliferative activity in humans and pH 2 labile properties characteristic of native human gamma interferon. The amino acid sequence of such an interferon comprises, from the N terminus: ##STR1## wherein X is a methionine residue or hydrogen and Y is a glutamine residue or, where X is hydrogen, Y is either a glutamine or a pyroglutamate residue.
    Type: Grant
    Filed: September 23, 1994
    Date of Patent: November 12, 1996
    Assignee: Genentech, Inc.
    Inventors: Patrick W. Gray, Ernst H. Rinderknecht
  • G protein-coupled receptor kinase GRK6
    Patent number: 5532151
    Abstract: The present invention provides purified and isolated polynucleotide sequences encoding the novel G protein-coupled receptor kinase designated GRK6. Also provided by the invention are methods and materials for the recombinant production of GRK6 enzyme and methods for identifying compounds which modulate the protein kinase activity of GRK6.
    Type: Grant
    Filed: March 31, 1994
    Date of Patent: July 2, 1996
    Assignee: ICOS Corporation
    Inventors: David Chantry, Patrick W. Gray, Merl F. Hoekstra
  • Human immune interferon
    Patent number: 5096705
    Abstract: Disclosed is a complete description of the preparation of novel, recombinant human immune interferon and des-CYS-TYR-CYS recombinant human immune interferon via recombinant DNA techniques utilizing any of an assortment of expression vectors and host cultures. The human immune (gamma) interferon (IFN-.gamma.), is isolated and characterized in terms of DNA and amino acid sequences, physical attributes and biological activity.
    Type: Grant
    Filed: July 31, 1990
    Date of Patent: March 17, 1992
    Assignee: Genentech, Inc.
    Inventors: David V. Goeddel, Patrick W. Gray
  • Human immune interferon
    Patent number: 4929554
    Abstract: Disclosed is a complete description of the preparation of novel, recombinant human immune interferon and des-CYS-TYR-CYS recombinant human immune interferon via recombinant DNA techniques utilizing any of an assortment of expression vectors and host cultures. The human immune (gamma) interferon (IFN-.gamma.), is isolated and characterized in terms of DNA and amino acid sequences, physical attributes and biological activity.
    Type: Grant
    Filed: September 4, 1987
    Date of Patent: May 29, 1990
    Inventors: David V. Goeddel, Patrick W. Gray
  • Human immune interferon
    Patent number: 4925793
    Abstract: Disclosed is a complete description of the preparation of novel, recombinant human immune interferon and des-CYS-TYR-CYS recombinant human immune interferon via recombinant DNA techniques utilizing any of an assortment of expression vectors and host cultures. The human immune (gamma) inteferon (IFN-.gamma.), is isolated and characterized in terms of DNA and amino acid sequences, physical attributes and biological activity.
    Type: Grant
    Filed: August 4, 1987
    Date of Patent: May 15, 1990
    Assignee: Genentech, Inc.
    Inventors: David V. Goeddel, Patrick W. Gray
  • Recombinant gamma interferons having enhanced stability and methods therefor
    Patent number: 4855238
    Abstract: The present invention relates to novel, stable recombinant gamma interferons exhibiting in greater or less degree the antiviral and antiproliferative activity in humans and pH 2 labile properties characteristic of native human gamma interferon. The amino acid sequence of such an interferon comprises, from the N terminus: ##STR1## wherein X is a methionine residue or hydrogen and Y is a glutamine residue or, where X is hydrogen, Y is either a glutamine or a pyroglutamate residue.
    Type: Grant
    Filed: February 27, 1984
    Date of Patent: August 8, 1989
    Assignee: Genentech, Inc.
    Inventors: Patrick W. Gray, Ernst H. Rinderknecht
  • Human immune interferon
    Patent number: 4762791
    Abstract: Disclosed is a complete discription of the preparation of novel, recombinant human immune interferon via recombinant DNA techniques utilizing any of an assortment of expression vectors and host cultures. The recombinant human immune (gamma) interferon (IFN-.gamma.), is isolated and characterized in terms of its DNA and amino acid sequences, physical attributes and biological activity. A des-CYS-TYR-CYS species is also prepared.
    Type: Grant
    Filed: June 20, 1985
    Date of Patent: August 9, 1988
    Assignee: Genentech, Inc.
    Inventors: David V. Goeddel, Patrick W. Gray