Patents by Inventor Patrick W. Kleyn

Patrick W. Kleyn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genes and polymorphisms associated with cardiovascular disease and their use
    Publication number: 20030224418
    Abstract: Genes and polymorphisms associated with cardiovascular disease, methods that use the polymorphism to detect a predisposition to developing high cholesterol, low HDL or cardiovascular disease, to profile the response of subjects to therapeutic drugs and to develop therapeutic drugs are provided.
    Type: Application
    Filed: March 27, 2003
    Publication date: December 4, 2003
    Inventors: Andreas Braun, Patrick W. Kleyn, Aruna Bansal
  • Screening methods for compounds useful for the treatment of body weight disorders, including obesity
    Patent number: 6605437
    Abstract: The present invention relates to the identification of novel nucleic acid molecules and proteins encoded by such nucleic acid molecules or degenerate variants thereof, that participate in the control of mammalian body weight. The nucleic acid molecules of the present invention represent the genes corresponding to the mammalian tub gene, a gene that is involved in the regulation of body weight.
    Type: Grant
    Filed: March 22, 2001
    Date of Patent: August 12, 2003
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Patrick W. Kleyn, Karen J. Moore
  • Genes and polymorphisms associated with cardiovascular disease and their use
    Publication number: 20030036057
    Abstract: Genes and polymorphisms associated with cardiovascular disease, methods that use the polymorphism to detect a predisposition to developing high cholesterol, low HDL or cardiovascular disease, to profile the response of subjects to therapeutic drugs and to develop therapeutic drugs are provided.
    Type: Application
    Filed: March 9, 2001
    Publication date: February 20, 2003
    Inventors: Andreas Braun, Patrick W. Kleyn, Aruna Bansal
  • Screening methods for compounds useful for the treatment of body weight disorders, including obesity
    Publication number: 20020068286
    Abstract: The present invention relates to the identification of novel nucleic acid molecules and proteins encoded by such nucleic acid molecules or degenerate variants thereof, that participate in the control of mammalian body weight. The nucleic acid molecules of the present invention represent the genes corresponding to the mammalian tub gene, a gene that is involved in the regulation of body weight.
    Type: Application
    Filed: March 22, 2001
    Publication date: June 6, 2002
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Patrick W. Kleyn, Karen J. Moore
  • RP compositions and therapeutic and diagnostic uses therefor
    Patent number: 6399760
    Abstract: The present invention, which is based on the discovery of novel genes encoding rp polypeptides, features therapeutics, diagnostics and screening assays.
    Type: Grant
    Filed: August 29, 1996
    Date of Patent: June 4, 2002
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Carlos J. Gimeno, Patrick W. Kleyn, Karen J. Moore
  • RP compositions and diagnostic uses therefor
    Patent number: 6268130
    Abstract: The invention provides isolated nucleic acids molecules, designated retinitis pigmentosa (“rp”) nucleic acid molecules, which encode polypeptides involved in the regulation of sensory functions, e.g., retinal functions, e.g., functions of the rod and cone photoreceptor cells of the retina, body weight, and/or metabolic functions. The invention also provides antisense nucleic acid molecules, expression vectors containing rp nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an rp gene has been introduced or disrupted. The invention still further provides isolated rp polypeptides, fusion proteins, antigenic peptides, and anti-rp antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Grant
    Filed: October 22, 1997
    Date of Patent: July 31, 2001
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Patrick W. Kleyn, Karen J. Moore
  • Compositions for the treatment and diagnosis of body weight disorders, including obesity
    Patent number: 6207386
    Abstract: The present invention relates to the identification of novel nucleic acid molecules and proteins encoded by such nucleic acid molecules or degenerate variants thereof, that participate in the control of mammalian body weight. The nucleic acid molecules of the present invention represent the genes corresponding to the mammalian tub gene, a gene that is involved in the regulation of body weight.
    Type: Grant
    Filed: September 24, 1999
    Date of Patent: March 27, 2001
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Patrick W. Kleyn, Karen J. Moore
  • Compositions for the treatment and diagnosis of body weight disorders, including obesity
    Patent number: 6043346
    Abstract: The present invention relates to antibodies which specifically bind to mammalian tub gene products, tub peptide fragments and tub peptides produced by genetically engineered cells.
    Type: Grant
    Filed: February 10, 1999
    Date of Patent: March 28, 2000
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Patrick W. Kleyn, Karen J. Moore
  • Methods for identifying compounds that bind to a mammalian tub protein
    Patent number: 5876919
    Abstract: The present invention relates to the identification of novel nucleic acid molecules and proteins encoded by such nucleic acid molecules or degenerate variants thereof, that participate in the control of mammalian body weight. The nucleic acid molecules of the present invention represent the genes corresponding to the mammalian tub gene, a gene that is involved in the regulation of body weight.
    Type: Grant
    Filed: September 24, 1997
    Date of Patent: March 2, 1999
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Patrick W. Kleyn, Karen J. Moore
  • Methods for detecting mammalian tub protein and RNA
    Patent number: 5871931
    Abstract: The present invention relates to the identification of novel nucleic acid molecules and proteins encoded by such nucleic acid molecules or degenerate variants thereof, that participate in the control of mammalian body weight. The nucleic acid molecules of the present invention represent the genes corresponding to the mammalian tub gene, a gene that is involved in the regulation of body weight.
    Type: Grant
    Filed: September 24, 1997
    Date of Patent: February 16, 1999
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Patrick W. Kleyn, Karen J. Moore
  • Methods for identifying compounds that modulate mammalian tub protein activity
    Patent number: 5861239
    Abstract: The present invention relates to the identification of novel nucleic acid molecules and proteins encoded by such nucleic acid molecules or degenerate variants thereof, that participate in the control of mammalian body weight. The nucleic acid molecules of the present invention represent the gene corresponding to the mammalian tub gene, a gene that is involved in the regulation of body weight. The present invention also relates to methods for identifying compounds that modulate tub protein activity.
    Type: Grant
    Filed: September 2, 1997
    Date of Patent: January 19, 1999
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Patrick W. Kleyn, Karen J. Moore, Rosana Kapeller
  • Mammalian tub protein
    Patent number: 5817762
    Abstract: The present invention relates to the identification of novel nucleic acid molecules and proteins encoded by such nucleic acid molecules or degenerate variants thereof, that participate in the control of mammalian body weight. The nucleic acid molecules of the present invention represent the genes corresponding to the mammalian tub gene, a gene that is involved in the regulation of body weight.
    Type: Grant
    Filed: March 28, 1997
    Date of Patent: October 6, 1998
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Patrick W. Kleyn, Karen J. Moore
  • Mammalian tub gene
    Patent number: 5646040
    Abstract: The present invention relates to the identification of novel nucleic acid molecules and proteins encoded by such nucleic acid molecules or degenerate variants thereof, that participate in the control of mammalian body weight. The nucleic acid molecules of the present invention represent the genes corresponding to the mammalian tub gene, a gene that is involved in the regulation of body weight.
    Type: Grant
    Filed: April 12, 1996
    Date of Patent: July 8, 1997
    Assignee: Millennium Pharmaceutical, Inc.
    Inventors: Patrick W. Kleyn, Karen J. Moore