Patents by Inventor Patrick W. Rafter

Patrick W. Rafter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies specific for cystic fibrosis transmembrane conductance regulator and uses therefor
    Patent number: 5981714
    Abstract: Antibodies for binding epitopes of cystic fibrosis transmembrane conductance regulator (CFTR) and hybridomas which produce such antibodies are described. The antibodies of the present invention can be used in a method for detecting CFTR in a biological sample and/or in a method for purifying CFTR from an impure solution. In addition, the present invention includes a method for detecting CFTR in a biological sample from a nonhuman cystic fibrosis knockout animal wherein the the nonhuman cystic fibrosis knockout animal has been subjected to human CFTR replacement therapy. Another aspect of the present invention is a method for determining the orientation of CFTR in the membrane of a lipid vesicle. Yet another aspect of the invention is a kit for detecting CFTR in a biological sample.
    Type: Grant
    Filed: August 15, 1996
    Date of Patent: November 9, 1999
    Assignee: Genzyme Corporation
    Inventors: Seng H. Cheng, John Marshall, Richard J. Gregory, Patrick W. Rafter