Abstract: Provided herein are phosphodiesterase 4 (PDE4) degraders, e.g., a compound of Formula (I) or (IA), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a PDE4-mediated disease, disorder, or condition.

Abstract: A hydraulic system for a machine includes an implement pump, a valve, and an implement valve subsystem. The implement pump includes a load sensing control, and the valve controls the flow of hydraulic fluid to the implement pump. The implement valve subsystem includes one or more implement control subsystems to control movement of an implement. The valve is an electrohydraulic proportional relief valve and includes a solenoid configured to adjust the pressure of hydraulic fluid delivered to the implement pump proportionally to a current delivered through the solenoid.

Abstract: A hydraulic system for a machine includes an implement pump, a valve, and an implement valve subsystem. The implement pump includes a load sensing control, and the valve controls the flow of hydraulic fluid to the implement pump. The implement valve subsystem includes one or more implement control subsystems to control movement of an implement. The valve is an electrohydraulic proportional relief valve and includes a solenoid configured to adjust the pressure of hydraulic fluid delivered to the implement pump proportionally to a current delivered through the solenoid.

Abstract: A machine includes a front section having front wheels, a rear section having rear wheels, and a pivot that couples the front section to the rear section as well as a hydraulic steering circuit that moves the front section relative to the rear section about the pivot. The machine also includes a stabilizer and further includes a directional control valve that selectively depressurizes the hydraulic steering circuit according to a state of the stabilizer.

Abstract: A machine includes a front section having front wheels, a rear section having rear wheels, and a pivot that couples the front section to the rear section as well as a hydraulic steering circuit that moves the front section relative to the rear section about the pivot. The machine also includes a stabilizer and further includes a directional control valve that selectively depressurizes the hydraulic steering circuit according to a state of the stabilizer.

Abstract: A hydraulic system with margin based flow supplementation is provided. The hydraulic system includes a steering pump, an implement pump and a flow sharing device. The steering pump is associated with a steering circuit. The implement pump is associated with an implement circuit. The flow sharing device is disposed between the steering circuit and the implement circuit and is configured to operate in one of a first mode and a second mode. Further, the flow sharing device allows hydraulic fluid to flow from the implement circuit to the steering circuit in the first mode, when a margin pressure of the steering circuit is below a threshold value, and the flow sharing device stops the hydraulic fluid to flow from the implement circuit to the steering circuit in the second mode, when the margin pressure of the steering circuit is equal to or above the threshold value.

Abstract: A method and apparatus for controlling discharge pressure and pump displacement of a plurality of variable displacement hydraulic pumps having connected discharge ports is provided. Each pump includes a swashplate and a control valve for controlling an angle of inclination of the swashplate. A desired first pump displacement control law is determined for a first pump and determined a desired second pump discharge pressure control law for a second pump. The first control law is used to determine a first intermediate control variable. The second control law is used to determine a second intermediate control variable. The control of the first and second pumps are combined using the first and second intermediate control variables. A desired first control valve setting for the control valve of the first pump is determined using the combined first and second intermediate control variables and the first control law.

Abstract: Methods, apparatuses, and computer program products for controlling the torque load of multiple variable displacement hydraulic pumps are described herein. A pump displacement limit for each variable displacement hydraulic pump is determined using a nonlinear control law to limit the total pump torque load of the variable displacement hydraulic pumps on the engine. The value of the actual pump displacement of each variable displacement hydraulic pump is controlled based upon the respective determined pump displacement limit.

Abstract: The present disclosure is directed toward a hydraulic control system. The system may have a pump and a tool actuator configured to move a tool with a flow of pressurized fluid provided by the pump. The system may further have a tool control valve configured to control the flow of pressurized fluid to the tool actuator. The system may also have a controller operably connected with the tool control valve and the pump. The controller may be configured to receive a tool movement request. The controller may further be configured to estimate a change in a flow demand across the tool control valve associated with the tool movement request. The controller may also be configured to command adjustment of a discharge flow rate of the pump based on the estimated change in flow demand to satisfy the tool movement request.

Abstract: A hydraulic control system for a machine is disclosed. The hydraulic control system may have a pump configured to pressurize fluid, a displacement control valve configured to affect displacement of the pump, and a tool control valve configured to receive pressurized fluid from the pump and to selectively direct to the pressurized fluid to a hydraulic actuator. The hydraulic control system may also have a controller in communication with the displacement control valve. The controller may be configured to determine a pressure gradient across the tool control valve substantially different than a desired pressure gradient, to determine a desired condition of the displacement control valve based the pressure gradient, and to determine a flow force applied to the displacement control valve based on the desired condition. The controller may be further configured to generate a load sense response signal directed to the displacement control valve based on the desired condition and the flow force.

Abstract: Methods, apparatuses, and computer program products for controlling the torque load of multiple variable displacement hydraulic pumps are described herein. A pump displacement limit for each variable displacement hydraulic pump is determined using a nonlinear control law to limit the total pump torque load of the variable displacement hydraulic pumps on the engine. The value of the actual pump displacement of each variable displacement hydraulic pump is controlled based upon the respective determined pump displacement limit.

Abstract: A method and apparatus for controlling discharge pressure and pump displacement of a plurality of variable displacement hydraulic pumps having connected discharge ports is provided. Each pump includes a swashplate and a control valve for controlling an angle of inclination of the swashplate. A desired first pump displacement control law is determined for a first pump and determined a desired second pump discharge pressure control law for a second pump. The first control law is used to determine a first intermediate control variable. The second control law is used to determine a second intermediate control variable. The control of the first and second pumps are combined using the first and second intermediate control variables. A desired first control valve setting for the control valve of the first pump is determined using the combined first and second intermediate control variables and the first control law.

Abstract: A hydraulic control system for a machine is disclosed. The hydraulic control system may have a pump configured to pressurize fluid, a displacement control valve configured to affect displacement of the pump, and a tool control valve configured to receive pressurized fluid from the pump and to selectively direct to the pressurized fluid to a hydraulic actuator. The hydraulic control system may also have a controller in communication with the displacement control valve. The controller may be configured to determine a pressure gradient across the tool control valve substantially different than a desired pressure gradient, to determine a desired condition of the displacement control valve based the pressure gradient, and to determine a flow force applied to the displacement control valve based on the desired condition. The controller may be further configured to generate a load sense response signal directed to the displacement control valve based on the desired condition and the flow force.

Abstract: The present disclosure is directed toward a hydraulic control system. The system may have a pump and a tool actuator configured to move a tool with a flow of pressurized fluid provided by the pump. The system may further have a tool control valve configured to control the flow of pressurized fluid to the tool actuator. The system may also have a controller operably connected with the tool control valve and the pump. The controller may be configured to receive a tool movement request. The controller may further be configured to estimate a change in a flow demand across the tool control valve associated with the tool movement request. The controller may also be configured to command adjustment of a discharge flow rate of the pump based on the estimated change in flow demand to satisfy the tool movement request.

Abstract: The portable brake of the present invention comprises a top bracket, a bottom bracket, a leg, a handle, a toggle plate, and a foot. The top bracket of the portable brake has a back plate, side plates, a bottom plate, a toggle joint, a rung hook, and a leg sheath. The bottom bracket comprises a back plate, side plates, a bottom plate, a rung hook, and a leg sheath. The top and bottom brackets secure a leg, which passes through the leg sheaths of the brackets and leg apertures in the bottom plates of the brackets. A toggle plate is connected at one end to the top of the leg, and is connected at the other end to a pair of hinge plates. The hinge plates are, in turn, connected to a handle and to the toggle joint of the top bracket.

Abstract: The portable brake of the present invention comprises a top bracket, a bottom bracket, a leg, a handle, a toggle plate, and a foot. The top bracket of the portable brake has a back plate, side plates, a bottom plate, a toggle joint, a rung hook, and a leg sheath. The bottom bracket comprises a back plate, side plates, a bottom plate, a rung hook, and a leg sheath. The top and bottom brackets secure a leg, which passes through the leg sheaths of the brackets and leg apertures in the bottom plates of the brackets. A toggle plate is connected at one end to the top of the leg, and is connected at the other end to a pair of hinge plates. The hinge plates are, in turn, connected to a handle and to the toggle joint of the top bracket.