Patents by Inventor Patrick W. Trown

Patrick W. Trown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Homogeneous Preparations of Chimeric Protein
    Publication number: 20080193441
    Abstract: Variant forms of chimeric protein molecules comprising a Factor VII moiety and an Fe region of an IgG1 moiety provide improved properties. The variants are more resistant to proteolytic degradation. Thus preparations of the variant forms are more homogeneous and have a longer half-life. The variant forms are used for treating cancer, atherosclerosis, psoriasis, diabetic retinopathy, wet macular degeneration, and rheumatoid arthritis.
    Type: Application
    Filed: November 10, 2004
    Publication date: August 14, 2008
    Applicant: ICONIC THERAPEUTICS, INC.
    Inventors: Patrick W. Trown, Michael I. Sherman, Kirk Dornbush
  • Lipopolysaccharide binding protein derivatives
    Patent number: 6376462
    Abstract: Disclosed are novel biologically active lipopolysaccharide binding protein (LBP) derivatives including LBP derivative hybrid proteins which are characterized by the ability to bind to and neutralize LPS and which lack the CD14-mediated immunostimulatory properties of holo-LBP.
    Type: Grant
    Filed: March 29, 1999
    Date of Patent: April 23, 2002
    Assignee: Xoma Corporation
    Inventors: Héle{overscore (n)}e Gazzano-Santoro, Georgia Theofan, Patrick W. Trown
  • Lipopolysaccharide binding protein derivatives
    Patent number: 5731415
    Abstract: Disclosed are novel biologically active lipopolysaccharide binding protein (LBP) derivatives including LBP derivative hybrid proteins which are characterized by the ability to bind to and neutralize LPS and which lack the CD14-mediated immunostimulatory properties of holo-LBP.
    Type: Grant
    Filed: June 17, 1994
    Date of Patent: March 24, 1998
    Assignee: XOMA Corporation
    Inventors: Helene Gazzano-Santoro, Georgia Theofan, Patrick W. Trown