Patents by Inventor Patrick Wai-Kwok Shum

Patrick Wai-Kwok Shum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Colony stimulating factor-1 receptor (CSF-1R) inhibitors
    Patent number: 11274108
    Abstract: Compounds of the formulas which are useful as colony stimulating factor-1 receptor inhibitors (“CSF-1R inhibitors”).
    Type: Grant
    Filed: July 19, 2016
    Date of Patent: March 15, 2022
    Assignee: GENZYME CORPORATION
    Inventors: John L. Kane, Jr., Claude Barberis, Mark Czekaj, Paul Erdman, Barret Giese, Michael Kothe, Tieu-Binh Le, Jinyu Liu, Liang Ma, Markus Metz, Vinod Patel, Andrew Scholte, Patrick Wai-Kwok Shum, Linli Wei
  • COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) INHIBITORS
    Publication number: 20190016707
    Abstract: Compounds of the formulas which are useful as colony stimulating factor-1 receptor inhibitors (“CSF-1R inhibitors”).
    Type: Application
    Filed: July 19, 2016
    Publication date: January 17, 2019
    Inventors: John L. KANE, Jr., Claude Barberis, Mark Czekaj, Paul Erdman, Barret Giese, Michael Kothe, Tieu-Binh Le, Jinyu Liu, Liang Ma, Markus Metz, Vinod Patel, Andrew Scholte, Patrick Wai-Kwok Shum, Linli Wei
  • Method and intermediates for the preparation of 2,2,2-trifluoro-N-(4-fluoro-3-pyridin-4-yl-benzyl)-acetamide hydrochloride
    Patent number: 8497379
    Abstract: The present invention is directed to a method for the preparation of 2,2,2-trifluoro-n-(4-fluoro-3-pyridin-4-yl-benzyl)-acetamide hydrochloride of the formula: and reaction intermediates used in the method.
    Type: Grant
    Filed: June 27, 2012
    Date of Patent: July 30, 2013
    Assignee: Sanofi
    Inventors: Yong Mi Choi-Sledeski, Nakyen Choy, Gregory B. Poli, John J. Shay, Jr., Patrick Wai-Kwok Shum, Adam W. Sledeski
  • SUBSTITUTED PYRIMIDINE AS A PROSTAGLANDIN D2 RECEPTOR ANTAGONIST
    Publication number: 20130005741
    Abstract: The present invention is directed to a 2,6-substituted-4-monosubstitutedamino-pyrimidine compound of formula (I): or an enantiomer thereof, or an ester prodrug or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising such a compound. The invention also includes a method of treatment of a patient by the administration of a pharmaceutically effective amount of such a compound.
    Type: Application
    Filed: September 11, 2012
    Publication date: January 3, 2013
    Applicant: AVENTIS PHARMACEUTICALS INC.
    Inventors: Keith John HARRIS, Joacy C. AGUIAR, Patrick Wai-Kwok SHUM, Zhicheng ZHAO, Gregory B. POLI, Gregory T. STOKLOSA, Yong-Mi CHOI-SLEDESKI, Stephan REILING
  • SUBSTITUTED PYRIMIDINES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS
    Publication number: 20130005728
    Abstract: The present invention is directed to a substituted pyrimidine compound of formula (I) or an enantiomer thereof, or a prodrug or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising such a compound. The invention also includes a method of treatment of a patient by the administration of a pharmaceutically effective amount of such a compound.
    Type: Application
    Filed: September 11, 2012
    Publication date: January 3, 2013
    Applicant: AVENTIS PHARMACEUTICALS INC.
    Inventors: Keith J. HARRIS, Joacy C. AGUIAR, Patrick Wai-Kwok SHUM, Zhicheng ZHAO, Gregory B. POLI, Gregory STOKLOSA, Yong-Mi CHOI-SLEDESKI, Stephan REILING, David STEFANY, Charles GARDNER
  • [4-(5-AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-[7-FLUORO-1-(2-METHOXY-ETHYL)-4-TRIFLUOROMETHOXY-1H-INDOL-3-YL]-METHANONE AS AN INHIBITOR OF MAST CELL TRYPTASE
    Publication number: 20120283445
    Abstract: The present invention is directed to an indole benzylamine compound of formula I: useful as an inhibitor of tryptase. In addition, the present invention is directed to the use of the compound for treating a patient suffering from, or subject to, a physiological condition in need of amelioration by inhibition of tryptase, comprising administering to the patient of a therapeutically effective amount of the compound, and to a pharmaceutical composition comprising a pharmaceutically effective amount of the compound of formula I, and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: June 27, 2012
    Publication date: November 8, 2012
    Applicant: SANOFI
    Inventors: Yong Mi CHOI-SLEDESKI, Nakyen CHOY, Gregory Bernard POLI, John J. SHAY, JR., Patrick Wai-Kwok SHUM, Adam W. SLEDESKI
  • [4 [4-(AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-(1H-PYRROLO-PYRIDIN-YL)-METHANONES AND SYNTHESIS THEREOF
    Publication number: 20120245199
    Abstract: The present invention relates herein to compounds and compositions for the treatment and amelioration of inflammatory disease. Specifically the present invention relates to compounds that having a tryptase inhibition activity and the intermediates thereof, pharmaceutical compositions comprising such compounds, and a method of treating subjects suffering from a condition disease or disorder that can be ameliorated by the administration of an inhibitor of tryptase.
    Type: Application
    Filed: June 5, 2012
    Publication date: September 27, 2012
    Applicant: SANOFI
    Inventors: Yong Mi CHOI-SLEDESKI, Thaddeus R. NIEDUZAK, Gregory B. POLI, Patrick Wai-Kwok SHUM, Gregory T. STOKLOSA, Zhicheng ZHAO
  • INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS
    Publication number: 20120245161
    Abstract: The present invention discloses and claims a series of substituted indolyl-piperidinyl benzylamines of the formula wherein R1, R2, R4 and R5 are as described herein. More specifically, the compounds of this invention are inhibitors of ?-tryptase and are, therefore, useful as pharmaceutical agents. Additionally, this invention also discloses methods of preparation of substituted indolyl-piperidinyl benzylamines.
    Type: Application
    Filed: June 5, 2012
    Publication date: September 27, 2012
    Applicant: SANOFI
    Inventors: Yong Mi CHOI-SLEDESKI, Guyan LIANG, Thaddeus R. NIEDUZAK, Gregory B. POLI, Patrick Wai-Kwok SHUM, Gregory T. STOKLOSA, Zhicheng ZHAO
  • TROPINONE BENZYLAMINES AS BETA-TRYPTASE INHIBITORS
    Publication number: 20120238600
    Abstract: The present invention discloses and claims a series of substituted tropinone benzylamines of formula (I): The compounds of this invention are inhibitors of ?-tryptase and are, therefore, useful as pharmaceutical agents. Additionally, this invention also discloses methods of preparation of substituted tropinone benzylamines.
    Type: Application
    Filed: June 5, 2012
    Publication date: September 20, 2012
    Applicant: SANOFI
    Inventors: Yong Mi CHOI-SLEDESKI, Guyan LIANG, Patrick Wai-Kwok SHUM
  • [4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[7-flouro-1-(2-methoxy-ethyl)-4-trifluorom as an inhibitor of mast cell tryptase
    Patent number: 8217178
    Abstract: The present invention is directed to an indole benzylamine compound of formula I: useful as an inhibitor of tryptase. In addition, the present invention is directed to the use of the compound for treating a patient suffering from, or subject to, a physiological condition in need of amelioration by inhibition of tryptase, comprising administering to the patient of a therapeutically effective amount of the compound, and to a pharmaceutical composition comprising a pharmaceutically effective amount of the compound of formula I, and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: February 16, 2011
    Date of Patent: July 10, 2012
    Assignee: Sanofi
    Inventors: Yong Mi Choi-Sledeski, Nakyen Choy, Gregory Bernard Poli, John J. Shay, Jr., Patrick Wai-Kwok Shum, Adam W. Sledeski
  • DISUBSTITUTED [4-(5-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]- 1H-INDOL-3-YL]-METHANONES
    Publication number: 20120142735
    Abstract: The present invention extends to a compound of formula I: or a pharmaceutically acceptable salt of said compound, or a pharmaceutical composition comprising the compound of formula I and a pharmaceutically acceptable carrier. The invention is also directed to the use of a compound of formula I as an inhibitor of tryptase and for treating a patient suffering from, or subject to, a physiological condition in need of amelioration by an inhibitor of tryptase. The invention further includes methods for the preparation of a compound of formula I.
    Type: Application
    Filed: February 14, 2012
    Publication date: June 7, 2012
    Applicant: SANOFI
    Inventors: Yong- Mi CHOI-SLEDESKI, Charles J. GARDNER, Guyan LIANG, Gregory B. POLI, Patrick Wai-Kwok SHUM, Grzegory T. STOKLOSA, Zhicheng ZHAO
  • [4-(5-AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-[7-FLUORO-1-(2-METHOXY-ETHYL)-4-TRIFLUOROMETHOXY-1H-INDOL-3-YL]-METHANONE AS AN INHIBITOR OF MAST CELL TRYPTASE
    Publication number: 20110201647
    Abstract: The present invention is directed to an indole benzylamine compound of formula I: useful as an inhibitor of tryptase. In addition, the present invention is directed to the use of the compound for treating a patient suffering from, or subject to, a physiological condition in need of amelioration by inhibition of tryptase, comprising administering to the patient of a therapeutically effective amount of the compound, and to a pharmaceutical composition comprising a pharmaceutically effective amount of the compound of formula I, and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: February 16, 2011
    Publication date: August 18, 2011
    Inventors: Yong Mi CHOI-SLEDESKI, Nakyen CHOY, Gregory Bernard POLI, John J. SHAY, JR., Patrick Wai-Kwok SHUM, Adam W. SLEDESKI