Abstract: Commands in a command queue are received and scheduled. For each of the commands, scheduling includes determining an age of a command based on an entrance time of the command in the command queue. When the age of the command satisfies a first threshold, marking all other commands in the command queue as not issuable when the command is a deterministic command, and marking all other commands in the command queue as not issuable when the command is a non-deterministic command and the intermediate command queue is not empty. Scheduling the command further includes determining whether the command is a read command and marking the command as not issuable when the command is a non-deterministic read command and the intermediate command queue is empty.

Abstract: Patients diagnosed with a cancer harboring an IDH-1 mutation can be treated by the administration of a therapeutically effective amount of a pharmaceutical composition comprising Compound 1, a selective inhibitor of 2-HG production from mIDH-1 enzymes including the R132 mutations R132C, R132H, R132L, R132G, and R132S.

Abstract: An insert for an arthropod trapping device. The insert comprising a substrate and a frame for supporting the substrate, where a surface of the substrate has an adhesive disposed thereon, an optional mounting bracket spaced apart from the adhesive surface of the insert and located at a first end of the insert, and an optional graspable tab extending from the frame at a second end of the insert.

Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

Abstract: A system generating, using a first addressable unit address decoder, a first addressable unit address based on an input address, an interleaving factor, and a number of first addressable units. The system then generating, using an internal address decoder, an internal address based on the input address, the interleaving factor, and the number of first addressable units. Generating the internal address includes: determining a lower address value by extracting lower bits of the internal address, determining an upper address value by extracting upper bits of the internal address, and adding the lower address value to the upper address value to generate the internal address. Using an internal power-of-two address boundary decoder and the internal address, the system then generating a second addressable unit address, a third addressable unit address, a fourth addressable unit address, and a fifth addressable unit address.

Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.

Abstract: Systems and methods can leverage images of remotely captured items to extract information, populate forms, authenticate users, and perform other actions.

Abstract: Techniques for automatic extraction and verification of location data are disclosed. In some embodiments, a web crawler is configured to identify uniform resource locators (URLs), including a URL for a website associated with a target entity. The web crawler is further configured to fetch a subset of webpages from the website associated with the target entity. The web crawler may restrict the webpages that are fetched from the website based, at least in part, on patterns in the first website that are indicative of where reliable location information may be found. The web crawler further identifies a primary location of the target entity within at least one webpage in the subset of webpages, populating and/or verifying the primary location of the target entity in an entity profile. The entity profile may be consumed by client applications to execute location-aware and/or location dependent functions.

Abstract: A modular, reconfigurable frame that can be combined into multiple standardized segments to create different core vehicle configurations is described herein. The frame includes a plurality of components that affix together universally to make multiple versions of cycle, vehicle, and airframe styles. The reconfigurable frame includes a quick pin and fastener that allows for transportation platforms to be incorporated into the frame in a modular fashion.

Abstract: Techniques for automatic extraction and verification of location data are disclosed. In some embodiments, a web crawler is configured to identify uniform resource locators (URLs), including a URL for a website associated with a target entity. The web crawler is further configured to fetch a subset of webpages from the website associated with the target entity. The web crawler may restrict the webpages that are fetched from the website based, at least in part, on patterns in the first website that are indicative of where reliable location information may be found. The web crawler further identifies a primary location of the target entity within at least one webpage in the subset of webpages, populating and/or verifying the primary location of the target entity in an entity profile. The entity profile may be consumed by client applications to execute location-aware and/or location dependent functions.

Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

Abstract: Provided herein are processes for the preparation of heteroaryl carboxylic acids.

Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

Abstract: Provided herein are processes for the preparation of heteroaryl carboxylic acids.

Abstract: Systems and methods can leverage images of remotely captured items to extract information, populate forms, authenticate users, and perform other actions.

Abstract: A modular, reconfigurable frame that can be combined into multiple standardized segments to create different core vehicle configurations is described herein. The frame includes a plurality of components that affix together universally to make multiple versions of cycle, vehicle, and airframe styles. The reconfigurable frame includes a quick pin and fastener that allows for transportation platforms to be incorporated into the frame in a modular fashion.

Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases cases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseeases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

Abstract: Provided herein are processes for the preparation of heteroaryl carboxylic acids.

Abstract: A vehicle advertising system comprises a processor configured to perform operations in response to instructions from a predefined instruction set, a memory, and an advertisement module comprising instructions selected from the instruction set. The instructions when executed on the processor are operable to receive identification and financing information regarding a specific vehicle for sale, to generate a first advertisement formatted for presentation in a search engine result listing based on at least the received identification information and the received financing information, to generate a second advertisement formatted for presentation on a vehicle dealer website landing page associated with the first advertisement and based on at least the received identification information and the received financing information, and to provide a predicted effectiveness score on at least one of the first advertisement and the second advertisement before publication of the at least one advertisement.