Abstract: Systems, methods, and non-transitory computer-readable storage media for detecting a wearing status of a wearable device, the wearing status indicating whether a user is wearing the wearable device and sending wearing status data to a companion communication device to control a behavior of the companion communication device.

Abstract: A fan blade apparatus for use in a high-volume, low-speed fan wherein the fan blade includes a body portion, a leading edge portion and a trailing portion. The fan blade coupled to an electric motor configured to rotate in an intended direction wherein the leading portion of the fan blade is at the forefront of the rotation of the blade. The leading edge portion of the fan blade includes a series of steps extending along the length of the leading edge. The stepped configuration creates turbulent air flow when the electric motor rotates in the intended direction.

Abstract: A humidification system has a tube configured to transport gases. The tube is configured to be soaked prior to use and has a bead to hold liquid. Heat applied to the bead causes the liquid to be released as vapour. Gases flowing through the tube are heated and humidified by the vapour.

Abstract: At least one printing fluid of a printing fluid supply system of a printing press is changed. A printing unit of the printing press includes a print head. At least a first printing fluid or second printing fluid is selectively conducted from at least one supply unit to the print head. The at least one supply unit includes a reservoir of the first printing fluid and a reservoir of the second printing fluid. The at least one supply unit further includes an intermediate tank of the first printing fluid and an intermediate tank of the second printing fluid arranged between the reservoirs and the print head in the flow direction of printing fluid. The first and second printing fluids are conducted from their respective intermediate tanks to the print head, and there is no return of the printing fluids from the intermediate tanks to the respective reservoirs.

Abstract: The present disclosure relates to novel compounds including formula (X) and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure.

Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K-? enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K-? signaling with the compounds and compositions of the disclosure.

Abstract: At least one printing fluid of a printing fluid supply system of a printing press is changed. A printing unit of the printing press includes a print head. At least a first printing fluid or second printing fluid is selectively conducted from at least one supply unit to the print head. The at least one supply unit includes a reservoir of the first printing fluid and a reservoir of the second printing fluid. The at least one supply unit further includes an intermediate tank of the first printing fluid and an intermediate tank of the second printing fluid arranged between the reservoirs and the print head in the flow direction of printing fluid. The first and second printing fluids are conducted from their respective intermediate tanks to the print head, and there is no return of the printing fluids from the intermediate tanks to the respective reservoirs.

Abstract: A diagnostic test device to perform a test on a biological or environmental sample is provided. In one aspect, the diagnostic test device includes a sample preparation reservoir; a dispensing mechanism that includes a sealing member and a piercing member; and at least one diagnostic test reservoir separated from the sample preparation reservoir by a seal. A predetermined volume of fluid is defined between the sealing member, the piercing member, sides of at least one chamber defined by the sample preparation reservoir, and the seal when the sealing member engages the sides of the at least one chamber. The piercing member disrupts the at least one seal to dispense the predetermined volume of fluid to the at least one diagnostic test reservoir. The sealing member is configured to directly contact the sides of the at least one chamber as the seal is disrupted.

Abstract: An active smoke filtration unit is used to remove smoke during laparoscopic surgery. The active smoke filtration unit is part of a recirculation circuit. The recirculation circuit is pneumatically isolated from a primary flow generator, such as an insufflator, by a valve assembly. The active smoke filtration unit can be housed separately from the valve assembly or together with the valve assembly. The recirculation circuit can include a humidifier to beat and humidify the insufflation gases.

Abstract: Disclosed herein include methods, compositions, and kits suitable for use in sample testing. The sample testing systems can comprise a cartridge body to receive a sample, at least one reaction chamber coupled to the cartridge body, and at least one seal between the cartridge body and the at least one reaction chamber. The sample testing system can comprise a sample dispensing mechanism operable to disrupt the at least one seal to dispense a predetermined sub-volume of sample fluid from the cartridge body into the at least one reaction chamber. The sample dispensing mechanism can comprise a dispense rod comprising at least one piercing tip that disrupts the at least one seal by forming at least one opening therein. The piercing tips can comprise a geometry configured to generate a large opening in the at least one seal.

Abstract: A diffuser for use with a wound retractor and configured to deliver gases includes an interface tube for connecting to a gases supply and a diffuser interface positioned at a proximal end of the interface tube, the diffuser interface configured for delivering gases received from the gases supply through the interface tube, and the diffuser interface comprising a diffusion mechanism configured to deliver gases in a diffusion direction. A wound retractor with an integrated diffuser is also disclosed. The wound retractor includes an upper ring, a lower ring, a sleeve extending between and connecting the upper ring to the lower ring, and an integrated diffuser interface having a gases inlet and a diffusion mechanism.

Abstract: A system is provided for delivering gas to a patient during a medical procedure. The system comprises a heater arranged to heat at least one of the gas and a humidification liquid. The system comprises a controller arranged to control the system according to a first mode during delivery of a first flow rate of gas and a second mode during delivery of a second flow rate of gas. The controller monitors an electrical characteristic of the heater to select the mode of operation and/or to determine an operating state of the system.

Abstract: A diffuser for use with a wound retractor and configured to deliver gases includes an interface tube for connecting to a gases supply and a diffuser interface positioned at a proximal end of the interface tube, the diffuser interface configured for delivering gases received from the gases supply through the interface tube, and the diffuser interface comprising a diffusion mechanism configured to deliver gases in a diffusion direction. A wound retractor with an integrated diffuser is also disclosed. The wound retractor includes an upper ring, a lower ring, a sleeve extending between and connecting the upper ring to the lower ring, and an integrated diffuser interface having a gases inlet and a diffusion mechanism.

Abstract: A customer risk trigger associated with a customer may be identified. A response to the customer risk trigger may be detected. First risk analysis data related to the customer risk trigger may be gathered, based on the response, from a first datastore. Second risk analysis data related to the customer risk trigger may be gathered, based on the response, from a second datastore. A customer risk profile to model risk attribute(s) of the customer may be gathered. The risk attributes may represent a risk correlation between the customer and a prohibited act. Customer risk visualization tool(s) configured to facilitate visual user interaction with the customer risk profile may be gathered. The customer risk visualization tools may be rendered in a display of the computing system. The customer risk visualization tools provide a customer-centric view of risk for various applications, including anti-money laundering applications.

Abstract: The present disclosure relates to novel compounds including formula (X) and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure.

Abstract: Cellular biological activities are tightly controlled by intracellular signaling processes initiated by extracellular signals. Protein tyrosine phosphatases, which remove phosphate groups from tyrosine phosphorylated signaling molecules, play equally important tyrosine roles as protein kinases in signal transduction. SHP-2, a cytoplasmic SH2 domain containing protein tyrosine phosphatase, is involved in the signaling pathways of a variety of growth factors and cytokines. Recent studies have clearly demonstrated that this phosphatase plays an important role in transducing signal relay from the cell surface to the nucleus, and is a critical intracellular regulator in mediating cell proliferation and differentiation.

Abstract: A system is provided for delivering gas to a patient during a medical procedure. The system comprises a heater arranged to heat at least one of the gas and a humidification liquid. The system comprises a controller arranged to control the system according to a first mode during delivery of a first flow rate of gas and a second mode during delivery of a second flow rate of gas. The controller monitors an electrical characteristic of the heater to select the mode of operation and/or to determine an operating state of the system.

Abstract: The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the invention. The present invention further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds ad compositions of the invention.

Abstract: Disclosed herein is an obturator and/or cannula configured for insertion of a trocar assembly into a surgical cavity and allowing insertion of medical instruments into the surgical cavity through the cannula after removal of the obturator. The cannula can include an obturator for use in a trocar assembly. A trocar assembly is disclosed including a cannula having a shaft, optionally with a lumen, and one or more elements protruding outwardly from a surface of the lumen and an obturator. The obturator can comprise a shaft with one or more portions configured to accommodate the one or more elements protruding from the lumen surface when the obturator shaft is located in the lumen of the cannula.

Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions thereof and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure.