Abstract: The invention relates to biomarkers for assessing the disease status of a subject with an antibody-associated autoimmune disease, in particular a neurological disease such as neuromyelitis optica spectrum disorders (NMOSD) or LGI1-antibody encephalitis. The invention in particular looks at the presence or levels of IgM isotype antibodies which recognise a specific antigen in an anti-body-associated autoimmune disease, which is used to determine whether a subject is in a relapse.

Abstract: The invention relates to a method of identifying patients who are positive for CASPR2 autoantibodies which are predicted to respond to immunotherapy, the method comprising i) obtaining a sample from a subject having autoantibodies against CASPR2; and ii) screening for the presence of the allele HLA DRB1*11:01. The invention also relates to one or more novel isolated peptides, wherein the peptide comprises the sequence of any of Seq ID no: 1 to Seq ID no: 57 or a sequence having at least 80%, 85%, 90%, 95% or more sequence identity with one of Seq ID no 1 to 7, preferably with one of Seq ID no 40 to 57.

Abstract: The invention relates to methods of determining whether or not an individual has or is likely to develop a neurological disease and related methods and kits.

Abstract: The invention relates to methods of determining whether or not an individual has or is likely to develop a neurological disease and related methods and kits.

Abstract: A compliant cam system includes a cam having a cam body rotatable with respect to a cam rotational axis. The cam body has a cam body center spaced from the cam rotational axis. At least a portion of the cam is an elastically compressible material. A follower having at least one follower surface is in contact with the compressible material portion of the cam. A cam non-deflected condition is defined when an elastically compressible material portion outer surface is in contact with the cam follower surface prior to deflection of the elastically compressible material portion. The cam when thereafter rotated with respect to the cam rotational axis moves the cam body center toward the follower. The elastically compressible material portion deflects, defining a deflected condition, creating a biasing force acting toward the follower, and releasably frictionally engaging the elastically compressible material portion with the follower.

Abstract: A mobile terminal is disclosed which includes a near field or RF ID tag. The mobile terminal communicates with the mobile telecommunications network and is authenticated with that network using the SIM. The mobile terminal is operable to obtain security data from the user thereof, such as a PIN or biometric data, or the mobile terminal incorporates a sensor such as a light sensor, pressure sensor, heat sensor, skin resistant sensor or inertial sensor. The input device or sensor is used to confirm the identity of the user or to evaluate whether the user wishes to use the near field tag to make a payment or obtain entry to a building. Data from the sensor is passed to the SIM, which issues a command enabling the near field tag, via link. The near field tag may then be read by a reader. The near field tag may be automatically disabled after being read by the reader, after a predetermined time, or when the stimulus to the sensor is no longer present.

Abstract: A compliant cam system includes a one-piece cam including: a cam body rotatable with respect to a cam rotational axis and a having a cam body center spaced from the cam rotational axis and an outer surface; and a deflecting arm freely extending from the cam body having a free end elastically deflected toward the cam body in an arm deflected condition. A follower has at least one follower surface in direct contact with the cam outer surface at the deflecting arm. An arm non-deflected condition is defined when the outer surface is in direct contact with the cam follower surface prior to deflection of the deflecting arm. The cam when thereafter rotated with respect to the cam rotational axis acts to move the cam body center toward the follower thereby deflecting the deflecting arm to the deflected condition creating a biasing force acting toward the follower.

Abstract: A mobile terminal is disclosed which includes a near field or RF ID tag. The mobile terminal communicates with the mobile telecommunications network and is authenticated with that network using the SIM. The mobile terminal is operable to obtain security data from the user thereof, such as a PIN or biometric data, or the mobile terminal incorporates a sensor such as a light sensor, pressure sensor, heat sensor, skin resistant sensor or inertial sensor. The input device or sensor is used to confirm the identity of the user or to evaluate whether the user wishes to use the near field tag to make a payment or obtain entry to a building. Data from the sensor is passed to the SIM, which issues a command enabling the near field tag, via link. The near field tag may then be read by a reader. The near field tag may be automatically disabled after being read by the reader, after a predetermined time, or when the stimulus to the sensor is no longer present.

Abstract: A compliant follower cam system includes a cam rotatable about a cam rotational axis continuously aligned with a cam displacement axis. The cam has a body center spaced from the rotational axis. A compliant follower has an elastically deformable first contact wall positioned proximate to a cavity. The first contact wall is directly contacted by the cam body outer surface. A compliant follower non-deflected condition occurs when a first contact wall outer surface directly contacts the cam body outer surface prior to deflection of the first contact wall, with the cam body center out of alignment with the displacement axis. Rotating the cam moves the body center toward the compliant follower into alignment with the displacement axis. The cam thereby deflects the first contact wall into the cavity defining a compliant follower deflected condition and creates a biasing force releasably frictionally engaging the first contact wall and cam.

Abstract: A compliant cam system includes a cam having a cam body rotatable with respect to a cam rotational axis. The cam body has a cam body center spaced from the cam rotational axis. At least a portion of the cam is an elastically compressible material. A follower having at least one follower surface is in contact with the compressible material portion of the cam. A cam non-deflected condition is defined when an elastically compressible material portion outer surface is in contact with the cam follower surface prior to deflection of the elastically compressible material portion. The cam when thereafter rotated with respect to the cam rotational axis moves the cam body center toward the follower. The elastically compressible material portion deflects, defining a deflected condition, creating a biasing force acting toward the follower, and releasably frictionally engaging the elastically compressible material portion with the follower.

Abstract: A mobile terminal is disclosed which includes a near field or RFID tag (41). The mobile terminal (1) communicates with the mobile telecommunications network and is authenticated with that network using the SIM (15). The mobile terminal (1) is operable to obtain security data from the user thereof, such as a PIN or biometric data, or the mobile terminal (1) incorporates a sensor such as a light sensor, pressure sensor, heat sensor, skin resistant sensor or inertial sensor. The input device or sensor is used to confirm the identity of the user or to evaluate whether the user wishes to use the near field tag (41) to make a payment or obtain entry to a building (for example). Data from the sensor is passed to the SIM (15), which issues a command enabling the near field tag (41), via link (43). The near field tag (41) may then be read by a reader.

Abstract: A compliant cam system includes a cam having a cam body rotatable with respect to a cam rotational axis. The cam body has a cam body center spaced from the cam rotational axis. At least a portion of the cam is an elastically compressible material. A follower having at least one follower surface is in contact with the compressible material portion of the cam. A cam non-deflected condition is defined when an elastically compressible material portion outer surface is in contact with the cam follower surface prior to deflection of the elastically compressible material portion. The cam when thereafter rotated with respect to the cam rotational axis moves the cam body center toward the follower. The elastically compressible material portion deflects, defining a deflected condition, creating a biasing force acting toward the follower, and releasably frictionally engaging the elastically compressible material portion with the follower.

Abstract: A compliant cam system includes a cam having a cam body rotatable with respect to a cam rotational axis. The cam body has a cam body center spaced from the cam rotational axis. At least a portion of the cam is an elastically compressible material. A follower having at least one follower surface is in contact with the compressible material portion of the cam. A cam non-deflected condition is defined when an elastically compressible material portion outer surface is in contact with the cam follower surface prior to deflection of the elastically compressible material portion. The cam when thereafter rotated with respect to the cam rotational axis moves the cam body center toward the follower. The elastically compressible material portion deflects, defining a deflected condition, creating a biasing force acting toward the follower, and releasably frictionally engaging the elastically compressible material portion with the follower.

Abstract: A compliant cam system includes a one-piece cam including: a cam body rotatable with respect to a cam rotational axis and a having a cam body center spaced from the cam rotational axis and an outer surface; and a deflecting arm freely extending from the cam body having a free end elastically deflected toward the cam body in an arm deflected condition. A follower has at least one follower surface in direct contact with the cam outer surface at the deflecting arm. An arm non-deflected condition is defined when the outer surface is in direct contact with the cam follower surface prior to deflection of the deflecting arm. The cam when thereafter rotated with respect to the cam rotational axis acts to move the cam body center toward the follower thereby deflecting the deflecting arm to the deflected condition creating a biasing force acting toward the follower.

Abstract: A compliant follower cam system includes a cam rotatable about a cam rotational axis continuously aligned with a cam displacement axis. The cam has a body center spaced from the rotational axis. A compliant follower has an elastically deformable first contact wall positioned proximate to a cavity. The first contact wall is directly contacted by the cam body outer surface. A compliant follower non-deflected condition occurs when a first contact wall outer surface directly contacts the cam body outer surface prior to deflection of the first contact wall, with the cam body center out of alignment with the displacement axis. Rotating the cam moves the body center toward the compliant follower into alignment with the displacement axis. The cam thereby deflects the first contact wall into the cavity defining a compliant follower deflected condition and creates a biasing force releasably frictionally engaging the first contact wall and cam.

Abstract: A mobile terminal is disclosed which includes a near field or RF ID tag (41). The mobile terminal (1) communicates with the mobile telecommunications network and is authenticated with that network using the SIM (15). The mobile terminal (1) is operable to obtain security data from the user thereof, such as a PIN or biometric data, or the mobile terminal (1) incorporates a sensor such as a light sensor, pressure sensor, heat sensor, skin resistant sensor or inertial sensor. The input device or sensor is used to confirm the identity of the user or to evaluate whether the user wishes to use the near field tag (41) to make a payment or obtain entry to a building (for example). Data from the sensor is passed to the SIM (15), which issues a command enabling the near field tag (41), via link (43). The near field tag (41) may then be read by a reader.