Abstract: The present invention relates to a method of treatment for chronic pain, opioid dependence, alcohol use disorder or autism using a class of pyrimidinone compounds, an adenylyl cyclase 1 (AC1) inhibitor. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using those compounds disclosed herein.

Abstract: A tooth assembly for use in a grinding wheel, the tooth assembly comprising a holder for holding at least one tooth within a slot of the grinding wheel, wherein the at least one tooth comprises a tooth body, wherein the at least one tooth is removably attached to the holder by attachment means comprising a recess within the tooth body and a fixing receivable in the recess.

Abstract: A tooth (2) for use in a grinding wheel (4), the tooth (2) including a spigot (8) for cooperating with a corresponding structure within a slot (10) of the grinding wheel (4) and a bolt (14) for locking the tooth (2) in the slot (10) of the wheel (4), and a grinding wheel (4) comprising the tooth (2).

Abstract: Embodiments generally relate to systems, apparatus and methods concerned with autonomous preparation of brewed beverages, such as coffee beverages. Some embodiments make use of at least one robotic arm in the brewed beverage preparation. Various embodiments use two robotic arms. Various embodiments have multiple separately controlled components with which the at least one robotic arm can interact as part of the coffee preparation process.

Abstract: A tooth (2) for use in a grinding wheel (4), the tooth (2) comprising means (8) for cooperating with a corresponding structure within a slot (10) of the grinding wheel (4) and means (14) for locking the tooth (2) in the slot (10) of the wheel (4), and a grinding wheel (4) comprising the tooth (2).

Abstract: A drive mechanism for use with an implement comprising a driving sprocket to drive a rotatable workpiece and at least one intermediate sprocket of different diameter to the driving sprocket to allow for change of speed and torque of the rotatable workpiece.

Abstract: A tree stump grinding machine includes a rotor having at least one or more peripheral slots therein and defining a rotor plane. One or more teeth are removably disposed in corresponding slots and form a primary cutting face. A secondary cutting face is formed by a protrusion on the tooth and/or a keeper plate associated with the tooth. The secondary cutting face may be formed by a protrusion on the keeper plate oriented perpendicular to the plane of the rotor, and/or the secondary cutting face may be disposed circumferentially and/or radially offset with respect to the primary cutting face on either of both of the tooth and the keeper plate.

Abstract: A tooth (30) for use in a grinding wheel is provided. The tooth comprises a main body (31) including a slot (32) comprising two substantially planar surfaces for, in use, engaging with a slot (24) in the rotor (20), and at least one cutting face (33, 34, 35, 36) connected to and extending away from the main body. In use, the force in the plane of the rotor is transferred from the tooth onto the rotor via one of the planar surfaces provided on the slot.

Abstract: A tooth (30) for use in a grinding wheel is provided. The tooth comprises a main body (31) including a slot (32) comprising two substantially planar surfaces for, in use, engaging with a slot (24) in the rotor (20), and at least one cutting face (33, 34, 35, 36) connected to and extending away from the main body. In use, the force in the plane of the rotor is transferred from the tooth onto the rotor via one of the planar surfaces provided on the slot.

Abstract: One aspect of the invention relates to a power generation system comprising an internal combustion engine that operates, generally by limiting the adiabatic flame temperature, to produce an engine exhaust that is low in NOx and particulate matter. The exhaust is treated by a fuel cell to remove organic compounds and CO while producing useful power. Another aspect of the invention relates to controlling the adiabatic flame temperature by EGR drawing from upstream of the fuel cell. A further aspect of the invention relates to treating engine exhaust with a reducing catalyst and then with a fuel cell. A still further aspect of the invention relates to treating exhaust with an intermediate temperature solid oxide fuel cell. A further aspect of the invention relates to a system equipped with a valve allowing exhaust to selectively bypass a fuel cell.

Abstract: One aspect of the invention relates to a clean power generation system in which an internal combustion engine is operated to produce shaft power and an exhaust stream. The exhaust stream is processed by a fuel cell. Fluctuations in power demand are met, at least in part, by increasing or decreasing power output from the fuel cell and/or power uptake or output from a power storage device. The engine can operate at a relatively constant rate, providing a steady exhaust stream, which facilitates pollution control and fuel cell operation. According to another aspect of the invention, the exhaust of an engine is treated with a fuel cell having an electrolyte that conducts protons. In addition to removing pollutants from the exhaust while generating useful power, the fuel cell can provide a supply of low acidity water. The water can be used in the fuel reformer.

Abstract: An optimally finished gear has a surface roughness between approximately 5 micro-inches Ra to 10 micro-inches Ra. The reduced surface roughness, when located at the gear teeth, can reduce the maximum contact stress by more than fifty percent. Similarly, the subsurface shear stress can be reduced by approximately thirty percent. The reduced contact stress and reduced shear stress results from improved lubrication conditions between the gear teeth. Surface roughness greater than 10 micro-inches Ra results in increased contact of the surface peaks, while surface roughness lower than 3 micro-inches is too smooth to retain adequate lubrication between the gear teeth.