Abstract: Provided herein is a compound of Formula (I): or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, a pharmaceutical composition comprising a compound of the present disclosure, together with a pharmaceutically acceptable excipient thereof, and a method of treating cancer with the same.

Abstract: A modular hydronic system core system and method includes a hydronic fluid flow conduit with closely spaced tees and distribution supply and return portions on a substrate. A supply manifold is coupled to branch feeders that support a circulator pump or zone valve. An ECM circulator along the conduit includes a Bluetooth transmitter to capture and transmit fluid flow rate and pressure. A return manifold includes branch returns with purge/shutoff valves. The branch feeders and returns are connectable to a distribution system having heating elements. Air and dirt separators, and an iron remover remove air, dirt and iron from the fluid. An expansion tank bracket supports a pressure gauge and expansion tank. A zone relay is coupled to the ECM circulator and zone valves on the branch feeders, and includes thermostat terminals. The zone relay captures inputs from the thermostats to control operation of the ECM circulator and zone valves.

Abstract: The present invention relates to the field of paintbrushes. The device relates to paintbrushes and the use of syringes to dispense paint onto the bristles. The self-cleaning paintbrush device is designed to make painting tasks easier and more efficient by allowing the user to dispense paint directly onto the bristles and to easily clean the brush after use. The device is comprised of a handle, a body, a plurality of bristles, and at least one syringe, as well as various components for attaching the syringe and controlling the flow of paint. The device may be made in a variety of sizes and shapes and may include various indicia on the surface of the body. The bristles may be made from nylon, polyester, or other materials commonly used in paintbrushes.

Abstract: In response to a programmatic interaction, respective representations of items of an initial result set are presented to an item consumer. One or more result refinement iterations are then conducted. In a given iteration, one or more feedback indicators with respect to one or more items are identified, a machine learning model is trained using at least the feedback indicators to generate respective result set candidacy metrics for at least some items, and the metrics are then used to transmit additional items for presentation to the item consumer.

Abstract: In response to a programmatic interaction, respective representations of items of an initial result set are presented to an item consumer. One or more result refinement iterations are then conducted. In a given iteration, one or more feedback indicators with respect to one or more items are identified, a machine learning model is trained using at least the feedback indicators to generate respective result set candidacy metrics for at least some items, and the metrics are then used to transmit additional items for presentation to the item consumer.

Abstract: An image forming device includes an image formation path extending from an entrance end adjacent to a source of supply of media sheets, past an image forming station, to an exit end adjacent to a top collection site adapted to receive media sheets, a duplex path extending from an inlet end adjacent the top collection site to an outlet end adjacent a lower front opening in the device, a media sheet directing mechanism disposed between the exit end of the image formation path, top collection site and inlet end of the duplex path and selectively operable to deliver printed media sheets to the top collection site or the inlet end of the duplex path, and a deflector mechanism between the lower front opening and the outlet end of the duplex path and operable to divert printed media sheets from the duplex path through the lower front opening to exterior of the device.

Abstract: An apparatus for stabilizing a shaft in an essentially horizontal position while an anchoring object at one end of the shaft is replaced without removal of an object at the opposite end of the shaft that would otherwise tend to destabilize the shaft from its essentially horizontal position includes a half-spool member configured to clamp above and around the shaft to resist torque around the rotor, under supports configured to attach to the half-spool member and clamp an underside of the shaft below the half-spool member, and a hydraulic or mechanical brake configured to resist torque on the shaft when the brake is engaged.

Abstract: An apparatus for stabilizing a shaft in an essentially horizontal position while an anchoring object at one end of the shaft is replaced without removal of an object at the opposite end of the shaft that would otherwise tend to destabilize the shaft from its essentially horizontal position includes a half-spool member configured to clamp above and around the shaft to resist torque around the rotor, under supports configured to attach to the half-spool member and clamp an underside of the shaft below the half-spool member, and a hydraulic or mechanical brake configured to resist torque on the shaft when the brake is engaged.

Abstract: A photobioreactor system including a light source, a plurality of interconnected pipes, and a liquid slurry containing an algae disposed within the pipes. The pipes are formed from a translucent polyvinyl chloride material that allows light having a plurality of wavelengths emitted from the light source that stimulate growth of the algae to pass through the material and is resistant to light having a wavelengths emitted from the light source that degrade the material.

Abstract: In a multi-family building, such as a condominium complex, a device for storing optical fiber cable for use by a resident, the cable being stored in a hidden manner. The device can fit behind hallway molding and penetrates the hallway drywall. The cable is fed through an aperture in the device and is stored in a bag attached to the device. The bag is located in the dead-space between the hallway-drywall and the drywall of the residence for which the stored cable is intended. When the occupant of the residence subscribes for cable service, the service technician retrieves the stored cable from its hidden location and feeds it into the residence at that time.

Abstract: In a multi-family building, such as a condominium complex, a device for storing optical fiber cable for use by a resident, the cable being stored in a hidden manner. The device can fit behind hallway molding and penetrates the hallway drywall. The cable is fed through an aperture in the device and is stored in a bag attached to the device. The bag is located in the dead-space between the hallway-drywall and the drywall of the residence for which the stored cable is intended. When the occupant of the residence subscribes for cable service, the service technician retrieves the stored cable from its hidden location and feeds it into the residence at that time.

Abstract: A photobioreactor system including a light source, a plurality of interconnected pipes, and a liquid slurry containing an algae disposed within the pipes. The pipes are formed from a translucent polyvinyl chloride material that allows light having a plurality of wavelengths emitted from the light source that stimulate growth of the algae to pass through the material and is resistant to light having a wavelengths emitted from the light source that degrade the material.

Abstract: An apparatus for stabilizing a shaft in an essentially horizontal position while an anchoring object at one end of the shaft is replaced without removal of an object at the opposite end of the shaft that would otherwise tend to destabilize the shaft from its essentially horizontal position includes a half-spool member configured to clamp above and around the shaft to resist torque around the rotor, under supports configured to attach to the half-spool member and clamp an underside of the shaft below the half-spool member, and a hydraulic or mechanical brake configured to resist torque on the shaft when the brake is engaged.

Abstract: An image forming device includes an image formation path extending from an entrance end adjacent to a source of supply of media sheets, past an image forming station, to an exit end adjacent to a top collection site adapted to receive media sheets, a duplex path extending from an inlet end adjacent the top collection site to an outlet end adjacent a lower front opening in the device, a media sheet directing mechanism disposed between the exit end of the image formation path, top collection site and inlet end of the duplex path and selectively operable to deliver printed media sheets to the top collection site or the inlet end of the duplex path, and a deflector mechanism between the lower front opening and the outlet end of the duplex path and operable to divert printed media sheets from the duplex path through the lower front opening to exterior of the device.

Abstract: An apparatus for stabilizing a shaft in an essentially horizontal position while an anchoring object at one end of the shaft is replaced without removal of an object at the opposite end of the shaft that would otherwise tend to destabilize the shaft from its essentially horizontal position includes a half-spool member configured to clamp above and around the shaft to resist torque around the rotor, under supports configured to attach to the half-spool member and clamp an underside of the shaft below the half-spool member, and a hydraulic or mechanical brake configured to resist torque on the shaft when the brake is engaged.

Abstract: A packaging having a sealed storage medium for housing deactivated wet cement product including a sealed, removably-attached separate compartment to house a chemical cement activator product, and a method of mixing each product within the packaging thereby eliminating the need for a separate mixing medium. The packaging is comprised of a waterproof, flexible plastic bag having one or more small holes with grommets into which a handle such as a looped rope can be affixed, to provide easy transport. The chemical activator with its storage compartment does not come into contact with the wet cement during storage or transport. The user may mix the contents of the chemical activator with the cement by simply opening the attached compartment housing the chemical activator, combining it with the deactivated wet cement within the compartment already housing the cement, and mixing the contents until the cement has been activated.