Abstract: A left atrial appendage closure (LAAC) device may be adapted for occluding a patient's left atrial appendage (LAA). The LAAC device includes a shape memory polymer foam body that is adapted to expand from a crimped configuration for delivery to an expanded configuration after delivery. The shape memory polymer foam body includes a first portion that is adapted to have a first foam characteristic and a second portion that is adapted to have a second foam characteristic that is different from the first foam characteristic. The first and second foam characteristics may include one or more of foam expansion rate, foam stiffness and foam density, for example.

Abstract: An implant includes a plurality of foam layers attached together, wherein each foam layer includes a plurality of wedges monolithically formed with a base portion. A cap layer of foam may be attached at an axial end of the foam layers attached together. The cap layer of foam is disk-shaped and is devoid of wedges. A method of making an implant includes cutting disk-shaped pieces of foam partially through their thickness to define pluralities of wedges monolithically formed with base portions, securing the base portions in a contracted configuration to flare the pluralities of wedges apart from each other, and attaching the base portions such that adjacent pluralities of wedges are interdigitated.

Abstract: A medical device include a polyurethane layer and a hydro-specific layer that is covalently bonded to the polyurethane layer. The polyurethane layer may include a plurality of monomer residues, at least some of which include pendent alkene groups. The hydro-specific layer may be a hydrophilic layer or a hydrophobic layer depending on the specific molecules used to form the hydro-specific layer. As an example, the hydro-specific layer may be covalently bonded to the polyurethane layer via a thiol-ene or alkene hydrothiolation reaction between the plurality of pendent alkene groups and a plurality of thiol-terminated hydro-specific molecules forming the hydro-specific layer.

Abstract: A left atrial appendage closure (LAAC) device may be adapted for occluding a patient's left atrial appendage (LAA). The LAAC device includes a shape memory polymer foam body that is adapted to expand from a crimped configuration for delivery to an expanded configuration after delivery. The shape memory polymer foam body. An adhesive layer is disposed relative to the shape memory polymer foam body.

Abstract: A left atrial appendage closure device may include a shape memory polymer foam and a radiopaque component integrated with the shape memory polymer foam to provide visibility under radiographic based imaging.

Abstract: An expandable foam implant includes an element formed from a shape memory polymer and radially crimped, where the radially crimped element has an axial or circumferential outer surface of tightly packed pores resistant to liquid ingress. The shape memory polymer element includes a surface treatment disposed on at least a first portion of the axial or circumferential outer surface, where liquid ingress into the first portion is faster than into a remainder of the axial or circumferential outer surface of the radially crimped element.

Abstract: An occlusive implant may include a framework configured to shift between collapsed and expanded configurations, and an occlusive fabric secured to the framework. The fabric includes shape memory characteristics such that the fabric is configured to shift from a first to a second configuration when exposed to a stimulus. A method of making the fabric includes intertwining a plurality of filaments into the fabric, defining a permanent shape of the fabric in the second configuration, and heat setting the fabric in the first configuration. A method of making a shape memory yarn includes forming a core filament, and wrapping at least one shape memory filament helically around the core filament. The at least one shape memory filament is formed from a shape memory polymer and is configured to shift from a first to a second configuration when exposed to a stimulus.

Abstract: Methods for synthesizing and processing shape memory foams. The methods include utilizing supercritical carbon dioxide as a solvent, blowing agent, cleaning agent, sterilant, and/or reticulating agent.

Abstract: A left atrial appendage closure (LAAC) device is adapted for occluding a patient's left atrial appendage (LAA). The LAAC device includes a shape memory polymer foam element that is adapted to expand from a crimped configuration for delivery to an expanded configuration after delivery and that includes, in its expanded configuration, a distal face and a proximal face. A tubular member extends proximally from the shape memory polymer foam element and defines a lumen extending through the tubular member.

Abstract: A medical device may include a first component and a shape memory foam component that is secured relative to the first component. The medical device may be formed by forming a foamable solution that over time progresses from an initial liquid pre-foam state to a subsequent mid-foam state in which the foamable solution is partially reacted and to a final foam state in which the foamable solution is fully reacted and then applying the foamable solution to the first component during one of the liquid pre-foam state, the subsequent mid-foam state and the final foam state.

Abstract: A left atrial appendage closure (LAAC) device is adapted for occluding a patient's left atrial appendage (LAA). The LAAC device includes a shape memory foam occlusive element that is adapted to expand from a crimped configuration for delivery to an expanded configuration after deployment, the shape memory foam occlusive element including in its expanded configuration a distal face, a proximal face and an intervening periphery. A reinforcing member is disposed relative to the shape memory foam occlusive element and is adapted to limit deformation of the shape memory foam occlusive element after the shape memory foam occlusive element has expanded into the expanded configuration.

Abstract: A system for occluding a patient's left atrial appendage (LAA) includes an expandable frame and one or more expandable elements. The expandable frame is moveable from a collapsed delivery configuration to an expanded deployment configuration in which the expandable frame is adapted to span across at least a portion of the LAA, the expandable frame defining an LAA volume distal of the expandable frame once deployed. The one or more expandable elements are adapted to be deployed behind the expandable frame in order to fill at least part of the LAA volume distal of the expandable frame, each of the one or more expandable elements adapted to expand subsequent to delivery.

Abstract: An occlusive implant system includes an occlusive implant comprising an expandable framework, and an occlusive disk configured to be fixedly attached to the occlusive implant. An occlusive portion of the disk may be disposed entirely proximal of the expandable framework. An occlusive implant system may include a core wire having a lumen, and an elongate strand slidably disposed within the lumen, wherein a distal end of the strand is secured to the framework. The core wire may be configured to advance the occlusive disk over the elongate strand and attach the occlusive disk to the occlusive implant. A kit for use with an occlusive implant system may include a plurality of occlusive disks. Each occlusive disk may be configured to be coupled to the expandable framework. Each occlusive disk may have a maximum radial extent in an unconstrained configuration different from other occlusive disks.

Abstract: An occlusive device may include a shape memory foam component having a compressed configuration in which the shape memory foam component has a first shape and an expanded configuration in which the shape memory foam component has a second shape that is different from the first shape. The occlusive device may be adapted to occlude a left atrial appendage (LAA), for example. The shape memory foam component may be formed by crimping a shape memory foam blank into an inverse shape that is an inverse of the second shape and subsequently cutting the shape memory foam component from the crimped shape memory foam blank, the shape memory foam component having the first shape.

Abstract: An occlusive implant system may include a delivery catheter, a core wire including a connection element disposed at a distal end, and a piece of expandable foam coupled to the connection element. An occlusive implant system may include a delivery catheter, a core wire may include a clamshell enclosure disposed at a distal end, and a piece of expandable foam, wherein the clamshell enclosure is configured to deliver and thereafter release the piece of expandable foam at a treatment site. An occlusive implant system may include a delivery catheter, a core wire including a connection element disposed at a distal end, a piece of expandable foam engaged with the connection element, and a polymer coating disposed on the piece of expandable foam, wherein the polymer coating is configured to degrade in vivo to release the piece of expandable foam from the connection element.

Abstract: A gap sealing system may include a piece of expandable foam configured to expand in vivo, and an anchoring element extending from the piece of expandable foam. The anchoring element may include at least one arm extending distally from the foam. The foam may be configured to be disposed proximal of an occlusive implant to occlude an ostium of the left atrial appendage. The at least one arm may be configured to extend into an interior of the implant in vivo to anchor the foam to the implant. A kit may include the piece of expandable foam, a second piece of expandable foam configured to expand in vivo, wherein the second piece of expandable foam has an overall volume different from the piece of expandable foam, a tubular member configured to deliver the piece of expandable foam, and a second tubular member configured to deliver the second piece of expandable foam.

Abstract: An implantable medical device includes a device body and an anchor secured relative to the device body. The anchor is adapted to secure the device body in a desired location. The anchor includes a shape memory polymeric component, where the shape memory polymeric component has a first configuration for initial implantation and has a second configuration subsequent to initial implantation. The shape memory polymeric component may include a shape memory foam. The shape memory polymeric component may include a shape memory polymer.

Abstract: An occlusive implant includes an expandable foam member in a compressed configuration and a biodegradable capsule disposed over the expandable foam member. The expandable foam member is made of a shape memory polymer, and the biodegradable capsule holds the expandable foam member in the compressed configuration for a first time period, after which the biodegradable capsule degrades, allowing the expandable form member to expand into an expanded configuration.

Abstract: An occlusive implant system includes a core wire having a lumen extending therethrough, an occlusive implant including an expandable framework releasably coupled to a distal end of the core wire, and an elongate strand extending along the core wire to the framework. The elongate strand extends into an interior of the framework. At least one piece of expandable foam may be configured to slide in a compressed configuration along the elongate strand into the interior of the framework. The at least one piece of expandable foam is configured to shift to an expanded configuration within the interior of the framework. The system may include a retaining structure holding at least one piece of expandable foam in the compressed configuration within the framework, wherein the retaining structure is engaged with the framework. The elongate strand may extend into the interior of the framework and be coupled to the retaining structure.

Abstract: Aspects herein relate to biocompatible polyisobutylene-fiber composite materials and related methods. In one aspect a biocompatible composite material is included. The biocompatible composite material can include a network of fibers comprising one or more polymers to form a substrate and a continuous polyisobutylene matrix that is non-porous and completely surrounds the electrospun fibers. Other aspects are included herein.