Abstract: Strategies for an objective associated with an offering set are obtained. A strategy assigns respective selection probabilities of receiving content associated with the offering set to users of a user population. Strategy optimization iterations are performed with respect to a sub-sample of the population and a subset of the strategies. In a given iteration, weights assigned to the strategies are used to determine aggregated selection probabilities for users, content pertaining to the offering set is presented to users selected based on the aggregated probabilities, and the weights are adjusted based on feedback metrics and an exploration-exploitation tradeoff parameter. Based on weights updated in the iterations, content associated with the offering set is presented to users which were not in the sub-sample.

Abstract: Aspects of the present disclosure includes methods to quantify methylation in a DNA sample, where the method includes treating the sample to encode the presence or absence of DNA methylation, adding to the sample a set of synthetic molecules e.g., quality control template (QCT) molecules), generating a co-amplification mixture, sequencing the co-amplification mixture, determining a number of methylated molecules in the sample based on the number of methylated reads from the sample and a number of reads from the set of synthetic molecules.

Abstract: Improved acoustic neurostimulation is provided by having two or more acoustic transducers generate an acoustic interference pattern in a region of a patient being treated. The apparatus has at least two operating modes it can switch between. A first operating mode has the transducers driven at the same frequency. A second operating mode has the transducers driven at different frequencies. Full control of the acoustic transducers allows the acoustic interference pattern to be varied electronically at will.

Abstract: Embodiments of a method for accurate determination of biological target abundance can include generating a first set of molecules associated with a target sequence, where the first set of molecules includes a first set of dilution tags associated with a relative concentration profile; generating a second set of molecules including a second set of dilution tags associated with the first set of dilution tags; generating a dilution tagged mixture; amplifying the subsets of dilution tagged genetic targets using the second set of molecules; generating a modified dilution tagged mixture from the amplified subsets; determining, for the biological sample, a count of the distinct molecules including the target sequence; and/or determining, for the biological sample, an assessment of relative concentrations distinct species, such as over a vast dynamic range.