Patents by Inventor Patrick Zarrinkar

Patrick Zarrinkar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Assays and kits for detecting protein binding
    Publication number: 20080058219
    Abstract: The invention provides methods for determining the interactions between phage-displayed proteins and test molecules. The phage-displayed proteins are contacted with a reference moiety in the presence and absence of a test molecule; the behavior of the phage-displayed proteins as a function of concentration of the test molecule permits calculation of the binding affinity of the phage-displayed protein for the test molecule.
    Type: Application
    Filed: August 23, 2007
    Publication date: March 6, 2008
    Applicant: Ambit Biosciences Corporation
    Inventors: David Lockhart, Patrick Zarrinkar, Daniel Treiber
  • Uncoupling of DNA insert propagation and expression of protein for phage display
    Publication number: 20070105093
    Abstract: The present invention provides an advance in phage display technology by permitting the uncoupling of the propagation of phages containing inserted sequences encoding heterologous polypeptides from the expression of said polypeptides. The invention provides phage constructs and methods for their use to permit phage coat protein expression, and thus phage propagation, in the absence of display of heterologous polypeptides, which may be expressed as a fusion with said coat protein in a regulated manner.
    Type: Application
    Filed: September 22, 2006
    Publication date: May 10, 2007
    Applicant: Ambit Biosciences Corporation
    Inventors: Pietro Ciceri, Patrick Zarrinkar, Daniel Treiber, David Lockhart
  • Treatment of diseases with kinase inhibitors
    Publication number: 20060234931
    Abstract: The invention is directed to the identification and use of additional targets of BIRB 796, imatinib mesylate, and BAY 43-9006. The new targets of BIRB 796, imatinib mesylate, and BAY 43-9006 can be used to screen for suitable therapeutic compounds. Also, novel therapeutic and prophylactic uses for BIRB 796, imatinib mesylate, and BAY 43-9006 are disclosed herein.
    Type: Application
    Filed: July 19, 2004
    Publication date: October 19, 2006
    Inventors: William Biggs, Todd Carter, Miles Fabian, David Lockhart, Patrick Zarrinkar, Daniel Treiber, Phillip Edeen
  • Pyrrole compounds and uses thereof
    Publication number: 20050182125
    Abstract: The invention provides pyrrole-containing compounds and methods of use thereof. Kits and pharmaceutical compositions comprising the pyrrole compounds of the invention are also provided. The compounds and compositions disclosed herein are preferably used in the treatment of neurodegenerative diseases, cardiovascular diseases, proliferative diseases, neuroinflammatory disorders, vascular disorders with an inflammatory component, and visual disorders. In particular, methods and compositions for the treatment of stroke are disclosed herein.
    Type: Application
    Filed: November 15, 2004
    Publication date: August 18, 2005
    Applicant: Ambit Biosciences Corporation
    Inventors: David Lockhart, Hitesh Patel, Zdravko Milanov, Shamal Mehta, Patrick Zarrinkar, William Biggs, Pietro Ciceri, Miles Fabian, Daniel Treiber
  • Assays and kits for detecting protein binding
    Publication number: 20050009099
    Abstract: The invention provides methods for determining the interactions between phage-displayed proteins and test molecules. The phage-displayed proteins are contacted with a reference moiety in the presence and absence of a test molecule; the behavior of the phage-displayed proteins as a function of concentration of the test molecule permits calculation of the binding affinity of the phage-displayed protein for the test molecule.
    Type: Application
    Filed: June 21, 2004
    Publication date: January 13, 2005
    Applicant: Ambit Biosciences Corporation
    Inventors: David Lockhart, Patrick Zarrinkar, Daniel Treiber