Abstract: A scalpel holder, having a grip piece with a longitudinal direction and a blade holder which is connected to the grip piece and which functions to receive a scalpel blade and hold the same fixed, wherein the grip piece has a slider guide which runs substantially in the longitudinal direction of the grip piece for the purpose of receiving a slider, wherein the same can be movably guided in said slider guide toward the blade holder, and the slider guide is arranged on the grip piece in such a manner that the end piece, the same designed with a wedge shape, of the slider which is guided in the slider guide in the direction of the blade holder slides past the scalpel blade while lifting the same out of the blade holder.