Patents by Inventor Patrik Verstreken

Patrik Verstreken has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targeting Synaptogyrin-3 in Tauopathy Treatment
    Publication number: 20220403021
    Abstract: The invention relates to identification of synaptogyrin-3 as a target for treating or inhibiting progression of tauopathies or symptoms of tauopathies. In particular, synaptogyrin-3 inhibitors for use as a medicament in general, and for treating or inhibiting progression of tauopathies or symptoms of tauopathies are envisaged. The invention further relates to methods for identification of or for screening for inhibitors of synaptogyrin-3.
    Type: Application
    Filed: April 20, 2022
    Publication date: December 22, 2022
    Inventors: Patrik Verstreken, Joseph McInnes, Lujia Zhou
  • Targeting synaptogyrin-3 in tauopathy treatment
    Patent number: 11332526
    Abstract: The invention relates to identification of synaptogyrin-3 as a target for treating or inhibiting progression of tauopathies or symptoms of tauopathies. In particular, synaptogyrin-3 inhibitors for use as a medicament in general, and for treating or inhibiting progression of tauopathies or symptoms of tauopathies are envisaged. The invention further relates to methods for identification of or for screening for inhibitors of synaptogyrin-3.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: May 17, 2022
    Assignees: VIB VZW, Katholieke Univeriteit Leuven, K.U. Leuven R&D
    Inventors: Patrik Verstreken, Joseph McInnes, Lujia Zhou
  • Means and methods for treatment of early-onset Parkinson's disease
    Patent number: 11202795
    Abstract: This application relates to the field of neurodegenerative diseases, more particularly to the field of Parkinson's disease. In particular, the disclosure describes that inhibitors reducing FAS activity can be used for treatment of Parkinson's disease, in particular, the treatment of patients suffering from Parkinson's disease having loss of function mutations in PINK1 or PARKIN genes.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: December 21, 2021
    Assignees: VIB VZW, Katholieke Universiteit Leuven, KU Leuven R&E
    Inventors: Patrik Verstreken, Vanessa Morais Epifânio, Melissa Vos
  • TARGETING SYNAPTOGYRIN-3 IN TAUOPATHY TREATMENT
    Publication number: 20200216531
    Abstract: The invention relates to identification of synaptogyrin-3 as a target for treating or inhibiting progression of tauopathies or symptoms of tauopathies. In particular, synaptogyrin-3 inhibitors for use as a medicament in general, and for treating or inhibiting progression of tauopathies or symptoms of tauopathies are envisaged. The invention further relates to methods for identification of or for screening for inhibitors of synaptogyrin-3.
    Type: Application
    Filed: July 16, 2018
    Publication date: July 9, 2020
    Inventors: Patrik Verstreken, Joseph McInnes, Lujia Zhou
  • COMPOUNDS FOR TREATMENT OF INTRACTABLE EPILEPSY AND DOORS SYNDROME
    Publication number: 20200093843
    Abstract: The present invention relates to the field of neurodegenerative diseases, and the prevention and/or treatment of TBC1D24-associated disorders, such as DOORS syndrome, (intractable) epilepsy, and nonsyndromic deafness. In particular, the present invention relates to phosphoinositide phosphatase inhibitors and screening methods for producing such inhibitors, more particularly, Synaptojanin-1 5? phosphatase inhibitors, to increase phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) levels in neuronal cells.
    Type: Application
    Filed: August 29, 2017
    Publication date: March 26, 2020
    Inventors: Patrik Verstreken, Kevin Lüthy, Wim Versées, Baptiste Fischer, Jone Paesmans
  • Restoring phosphorylation of a novel PINK1 substrate to treat parkinson's disease
    Patent number: 9879233
    Abstract: The present application relates to the field of Parkinson's disease (PD), particularly sporadic PD or PD associated with mutations in the mitochondrial kinase PINK1. A new substrate for this kinase, NdufA10, is identified herein. In Parkinson's disease, this protein is dephosphorylated, which is linked to a loss of mitochondrial membrane potential. It is shown that restoring or mimicking phosphorylation of NdufA10 restores the phenotypic defects associated with Parkinson's disease and is thus a new therapeutic paradigm.
    Type: Grant
    Filed: November 7, 2013
    Date of Patent: January 30, 2018
    Assignees: VIB VZW, KATHOLIEKE UNIVERSITEIT LEUVEN
    Inventors: Bart De Strooper, Patrik Verstreken, Vanessa Morais Epifânio
  • MEANS AND METHODS FOR TREATMENT OF EARLY-ONSET PARKINSON'S DISEASE
    Publication number: 20170319610
    Abstract: This application relates to the field of neurodegenerative diseases, more particularly to the field of Parkinson's disease. In particular, the disclosure describes that inhibitors reducing FAS activity can be used for treatment of Parkinson's disease, in particular, the treatment of patients suffering from Parkinson's disease having loss of function mutations in PINK1 or PARKIN genes.
    Type: Application
    Filed: November 20, 2015
    Publication date: November 9, 2017
    Inventors: Patrik Verstreken, Vanessa Morais Epifânio, Melissa Vos
  • Method and apparatus for the imaging of a labeled biological sample
    Patent number: 9569828
    Abstract: A method and apparatus for the imaging of a labeled biological sample. The method comprises illuminating the labeled biological sample, generating members of a time series of images if the labeled biological sample, generating a plurality of difference images between later members of the time series of images of earlier members of the time series of images and combining the plurality of difference images to generate a final image of the labeled biological sample.
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: February 14, 2017
    Assignees: VIB VZW, Katholieke Universiteit Leuven, K.U.
    Inventors: Sebastian Munck, Wim Annaert, Patrik Verstreken
  • RESTORING PHOSPHORYLATION OF A NOVEL PINK1 SUBSTRATE TO TREAT PARKINSON'S DISEASE
    Publication number: 20150299672
    Abstract: The present application relates to the field of Parkinson's disease (PD), particularly sporadic PD or PD associated with mutations in the mitochondrial kinase PINK1. A new substrate for this kinase, NdufA10, is identified herein. In Parkinson's disease, this protein is dephosphorylated, which is linked to a loss of mitochondrial membrane potential. It is shown that restoring or mimicking phosphorylation of NdufA10 restores the phenotypic defects associated with Parkinson's disease and is thus a new therapeutic paradigm.
    Type: Application
    Filed: November 7, 2013
    Publication date: October 22, 2015
    Applicants: KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D, VIB VZW
    Inventors: Bart DE STROOPER, Patrik VERSTREKEN, Vanessa MORAIS EPIFÂNIO
  • Co-administration of Light and a Therapeutic Agent to Stimulate Dysfunctional Mitochondria Affected By a Neurological Disorder
    Publication number: 20140276355
    Abstract: A method and device for stimulating a dysfunctional mitochondria in a human brain afflicted with a neurological disorder by stimulating the dysfunctional mitochondria at more than one level of its electron transport chain by co-administering more than one type of external stimulation such as the co-administration of both light and a therapeutic agent such as vitamin K2.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: MEDOS INTERNATIONAL SARL
    Inventors: Yanik Tardy, Patrik Verstreken
  • Method And Apparatus For The Imaging Of A Labeled Biological Sample
    Publication number: 20140118524
    Abstract: A method and apparatus for the imaging of a labeled biological sample. The method comprises illuminating the labeled biological sample, generating members of a time series of images if the labeled biological sample, generating a plurality of difference images between later members of the time series of images of earlier members of the time series of images and combining the plurality of difference images to generate a final image of the labeled biological sample.
    Type: Application
    Filed: October 26, 2012
    Publication date: May 1, 2014
    Inventors: Sebastian Munck, Wim Annaert, Patrik Verstreken