Patents by Inventor Patrizia Cossutta

Patrizia Cossutta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparation of macrocyclic chelants and the chelates thereof with paramagnetic metal ions
    Patent number: 6046324
    Abstract: A process for the preparation of complexes of macrocyclic chelants with paramagnetic metal trivalent ions of formula (XII) ##STR1## wherein R.sub.1, R.sub.2 and Me.sup.3+ are as described in the following, comprising: a) reaction of 1,4,7,10-tetraazacyclododecane with triethyl orthoformate to give 5H,9bH-2a,4a,7,9a-octahydrotetraazacycloocta[cd]pentalene; b) carboxymethylation reaction in water; c) hydrolysis reaction in basic conditions; d) alkylation according to known methods with an epoxide in water; e) complexation according to known methods carried out in water by addition of a paramagnetic metal salt; f) purification by diafiltration, final desalting of the aqueous solution on ion exchange resins and g) crystallization or recovery.
    Type: Grant
    Filed: May 24, 1999
    Date of Patent: April 4, 2000
    Assignee: Dibra S.p.A.
    Inventors: Giorgio Ripa, Alessandro Scala, Marcella Murru, Carlo Felice Viscardi, Marina Ausonio, Chiara Scotti, Patrizia Cossutta
  • Process for the preparation of macrocyclic chelants and the chelates thereof with paramagnetic metal ions
    Patent number: 6042810
    Abstract: A process for the preparation of complexes of macrocyclic chelants with paramagnetic metal trivalent ions of formula (XII) ##STR1## wherein R.sub.1, R.sub.2 and Me.sup.3+ are as described in the following, comprising: a) reaction of 1,4,7,10-tetraazacyclododecane with triethyl orthoformate to give 5H,9bH-2a,4a,7,9a-octahydrotetraazacycloocta[cd]pentalene; b) carboxymethylation reaction in water; c) hydrolysis reaction in basic conditions; d) alkylation according to known methods with an epoxide in water; e) complexation according to known methods carried out in water by addition of a paramagnetic metal salt; f) purification by diafiltration, final desalting of the aqueous solution on ion exchange resins and g) crystallization or recovery.
    Type: Grant
    Filed: May 24, 1999
    Date of Patent: March 28, 2000
    Assignee: Dibra S.p.A.
    Inventors: Giorgio Ripa, Alessandro Scala, Marcella Murru, Carlo Felice Viscardi, Marina Ausonio, Chiara Scotti, Patrizia Cossutta
  • Process for the preparation of macrocyclic chelants and the chelates thereof with paramagnetic metal ions
    Patent number: 5925752
    Abstract: A process for the preparation of complexes of macrocyclic chelants with paramagnetic metal trivalent ions of formula (XII) ##STR1## wherein R.sub.1, R.sub.2 and Me.sup.3+ are as described in the following, comprising: a) reaction of 1,4,7,10-tetraazacyclododecane with triethyl orthoformate to give 5H,9bH-2a,4a,7,9a-octahydrotetraazacycloocta?cd!pentalene; b) carboxymethylation reaction in water; c) hydrolysis reaction in basic conditions; d) alkylation according to known methods with an epoxide in water; e) complexation according to known methods carried out in water by addition of a paramagnetic metal salt; f) purification by diafiltration, final desalting of the aqueous solution on ion exchange resins and g) crystallization or recovery.
    Type: Grant
    Filed: June 10, 1998
    Date of Patent: July 20, 1999
    Assignee: Dibra S.p.A.
    Inventors: Giorgio Ripa, Alessandro Scala, Marcella Murru, Carlo Felice Viscardi, Marina Ausonio, Chiara Scotti, Patrizia Cossutta