Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: In a tooth whitening method, a whitening composition is applied to at least one tooth. The whitening composition is maintained on the at least one tooth for a first time period. After the first time period, a light radiation is directed toward the at least one tooth for a second time period. The first time period has a duration greater than 50% of a total duration of the first and second time periods.

Abstract: Oral care compositions and/or unit-dose oral care compositions comprising a high level of surfactant. Oral care compositions and/or unit-dose oral care compositions with a high foaming efficiency. Oral care compositions and/or unit-dose oral care compositions with one or more web forming materials, one or more surfactants, and a sugar alcohol.

Abstract: A kit includes a multi-phase oral composition for whitening teeth and an electromagnetic radiation source. The multi-phase oral composition for whitening teeth includes from about 0.002% to about 30%, by weight of the multi-phase oral composition, of a discontinuous aqueous phase having a bleaching agent, where a concentration of the bleaching agent is up to 10%, by weight of the multi-phase oral composition, and at least about 50%, by weight of the multi-phase oral composition, of a continuous hydrophobic phase of petrolatum. The electromagnetic radiation source is capable of directing electromagnetic radiation with one or more wavelength in the range from about 200 nm to about 1700 nm toward at least one tooth. The electromagnetic radiation source emits electromagnetic radiation in a range from about 100 mW/cm2 to about 250 mW/cm2.

Abstract: A system comprising a telematics device associated with a vehicle, a first computing device, a second computing device associated with a driver of the vehicle, and a server is disclosed. The server may be configured to receive maintenance data from the telematics device, determine a repair for the vehicle based on the maintenance data, send a request to the first computing device for the repair to be performed by one or more service providers, estimate a period of time for performing the repair, assign an alternative form of transportation to be provided to the driver during the estimated period of time, and send, to the second computing device, one or more notifications regarding at least one of the repair to be performed by the one or more service providers, the estimated period of time for the repair, or the assigned alternative transportation to be provided to the driver.

Abstract: A grain-boundary self-aligned resistive memory structure is provided enabling the closely-packed formation of multiple, oxide-based, ReRAM elements in parallel, each with its own compliance resistor. The structure is capable of forming multiple filaments, one per element, with the aim of reducing the variability in the composite ReRAM cell.

Abstract: To limit resistance variability across a resistive random-access memory (RRAM) call, the disclosure includes an RRAM cell with a resistance spreading layer within the RRAM cell between the top and bottom electrodes of the RRAM cell. The resistance spreading layer is in series with and has no impedance with a filament forming layer of the RRAM cell. The resistance spreading layer may be below the filament forming layer or the resistance spreading layer may be above the filament forming layer. The resistance spreading layer may further be in series with and has no impedance with the bottom electrode or the top electrode.

Abstract: A unit-dose dentifrice composition includes a soluble fibrous composition and a nonfibrous composition. The soluble fibrous composition includes web forming material and tin ion source. The nonfibrous composition includes abrasive. The abrasive and the tin ion source are in separate locations within the unit-dose dentifrice composition.

Abstract: An oral care article in form of a strip for use in the oral cavity. The oral care article includes a hydrophobic delivery carrier comprising embedded solid hydrophilic particles comprising at least one bleaching agent, wherein at least about 20 parts by weight of the particles dissolve in about 100 parts by weight of water and/or the particles increase in volume and/or weight by at least about 50% upon contact with water.

Abstract: An oral care article in form of a strip for use in the oral cavity. The oral care article comprises a solid hydrophobic delivery carrier comprising solid hydrophilic particles comprising a bleaching agent, wherein the solid hydrophilic particles are embedded in the carrier. The concentration of the bleaching agent at a first surface of the solid delivery carrier is greater than the concentration of the bleaching agent at a second surface of the solid delivery carrier and the overall concentration of the bleaching agent is from about 0.1% to about 15% by weight of the article.

Abstract: An oral care article in form of a strip for use in the oral cavity. The oral care article comprises a solid hydrophobic delivery carrier comprising solid hydrophilic particles comprising an active agent for oral care. The active agent(s) for oral care can include an anti-calculus agent, an anti-caries agent, an antimicrobial agent, a dentinal desensitizing agent, a bleaching agent, or combinations thereof. The concentration of the active agent for oral care at a first surface of the solid hydrophobic delivery carrier is greater than the concentration of the active agent at a second surface of the solid hydrophobic delivery carrier.

Abstract: An oral care article for use in the oral cavity includes a water insoluble delivery carrier comprising solid hydrophilic particles comprising at least one bleaching agent. At least about 20 parts by weight of the solid hydrophilic particles dissolve in about 100 parts by weight of water, and/or the solid hydrophilic particles increase by volume and/or weight by at least about 50% in water. The particles are embedded in the carrier partially below the first surface and partially at or above the first surface of the solid hydrophobic delivery carrier. A concentration of the bleaching agent is from about 0.01% to about 15%, by weight of the article.

Abstract: The invention is directed towards a battery. The battery includes a cathode, an anode, a separator between the cathode and the anode, and an electrolyte. The cathode includes a conductive additive and an electrochemically active cathode material. The electrochemically active cathode material includes a beta-delithiated layered nickel oxide. The beta-delithiated layered nickel oxide has a chemical formula. The chemical formula is LixAyNi1+a?zMzO2·nH2O where x is from about 0.02 to about 0.20; y is from about 0.03 to about 0.20; a is from about 0 to about 0.2; z is from about 0 to about 0.2; and n is from about 0 to about 1. Within the chemical formula, A is an alkali metal. The alkali metal includes potassium, rubidium, cesium, and any combination thereof. Within the chemical formula, M comprises an alkaline earth metal, a transition metal, a non-transition metal, and any combination thereof. The anode includes an electrochemically active anode material.

Abstract: Oral care compositions, such as whitening dentifrice compositions, whitening toothpaste compositions, and/or toothpaste compositions, include dicarboxylic acid, the dicarboxylic acid including malonic acid, methylmalonic acid, dimethylmalonic acid, dihydroxymalonic acid, salts thereof, or combinations thereof, where the composition has a ChemPC ?L of least about 7. Mouth rinse compositions include dicarboxylic acid, the dicarboxylic acid including malonic acid, methylmalonic acid, dimethylmalonic acid, dihydroxymalonic acid, salts thereof, or combinations thereof and at least about 75%, by weight of the composition, of water, where the composition has a ChemPC ?L of least about 7. The composition may be essentially free of, substantially free of, or free of polyphosphate.

Abstract: A multi-phase oral composition for whitening teeth.

Abstract: Delivery carriers having multi-phase oral compositions used with an electromagnetic radiation source for whitening teeth.

Abstract: Multi-phase oral care compositions for whitening teeth, including hydrophilic bleaching agent particles in a hydrophobic phase with a melting point of from about 40° C. to about 80° C. The hydrophilic bleaching agent particles can include peroxide compounds and/or hydrogen peroxide adducts. The hydrophilic bleaching agent particle can have a solubility in water of at least about 20 parts, by weight of the particles, in about 100 parts, by weight, of water.

Abstract: A primary battery includes a cathode having a non-stoichiometric metal oxide including transition metals Ni, Mn, Co, or a combination of metal atoms, an alkali metal, and hydrogen; an anode; a separator between the cathode and the anode; and an alkaline electrolyte.

Abstract: The invention is directed towards an electrochemically active cathode material for a battery. The electrochemically active cathode material includes a non-stoichiometric beta-delithiated layered nickel oxide. The non-stoichiometric beta-delithiated layered nickel oxide has a chemical formula. The chemical formula is LixAyNi1+a?zMzO2·nH2O where x is from about 0.02 to about 0.20; y is from about 0.03 to about 0.20; a is from about 0.02 to about 0.2; z is from about 0 to about 0.2; and n is from about 0 to about 1. Within the chemical formula, A is an alkali metal. The alkali metal includes potassium, rubidium, cesium, and any combination thereof. Within the chemical formula, M comprises an alkaline earth metal, a transition metal, a non-transition metal, and any combination thereof.

Abstract: Oral care compositions and/or unit-dose oral care compositions with a non-inferior amount of fluoride. Unit-dose oral care compositions comprising greater than 850 ppm, greater than 1000 ppm, greater than 1150 ppm, greater than 1450 ppm, or greater than 2000 ppm of fluoride. Unit-dose oral care compositions with a salivary fluoride pK AUC that is at least 60% of the salivary fluoride pK AUC of 1.25 g of the appropriate reference toothpaste when dosed according to the manufacturer's instructions.