Abstract: Implementations relate to methods, systems, and computer-readable media to automatically perform rigging of physics-based three-dimensional objects. In some implementations, the method may include obtaining a 3D mesh of a 3D object, segmenting the 3D mesh into two or more sub-meshes, wherein each sub-mesh corresponds to a respective part of the 3D object, determining a constraint graph for the 3D object using a transformer model, wherein the two or more sub-meshes are provided as input to the transformer model, and wherein the constraint graph defines a set of joints such that each joint defines constraints on motion of respective pairs of the parts of the 3D object, and calculating a plurality of parameters for the constraint graph based on one or more objective functions, wherein the sub-meshes, the constraint graph, and the plurality of parameters are usable to simulate motion of the 3D object in a virtual environment.

Abstract: The present disclosure is directed to one or more embodiments of mailer package assemblies including a fixed release liner and a mailer package. The fixed release liner is removably or detachably coupled to the mailer package by an adhesive layer. The fixed release liner includes one or more wickets (e.g., openings) such that the fixed release liner may be mounted to a wall by inserting fasteners (e.g., tack(s), pin(s), etc.) into the openings. The mailer package may be removed, detached, or decoupled from the fixed release liner by pulling on the mailer package decoupling the fixed release liner from the mailer package. After the mailer package is removed, an packaging associate may place an item or product within the mailer package to be shipped to a consumer. After the mailer package is removed from the fixed release liner, the fixed release liner remains mounted to the wall.

Abstract: The specification describes a catalyst for the hydrodeoxygenation of alcohols, comprising: 0.1 to 1.5 wt % palladium; 1.0 to 5.0 wt % molybdenum; and 0.05 to 0.5 wt % tin; on a zirconia support. Also described is a method for manufacturing the catalyst and a hydrodeoxygenation process using the catalyst.

Abstract: The specification describes a zirconia support comprising ?95 wt % ZrO2, wherein: the support has a crush strength of 20 to 140 N; the support has a total pore volume of 0.10 to 0.40 mL/g when measured by N2 physisorption; the support has an acid site density of 15 to 30 ?LNH3/m2; and the support has a basic site density of 0.006 to 0.015 wt %/m2 as measured by the MBOH test. Also described is a method for producing a zirconia supporting starting from zirconia or zirconium hydroxide as raw materials.

Abstract: Power draw stabilization is provided. A target power consumption of a source load is determined. The source load is generated by electronics supplied power by a primary power source through a power rail. The power rail is coupled to a capacitor bank by a bi-directional converter configured to smooth fluctuations in power drawn from the primary power source by performing mode switch operations. The mode switch operations include, in response to the source load exceeding a target power consumption, controllably switching to a second directional mode that directs current released from the capacitor bank to the power rail. The mode switch operations further include, in response to the source load dropping below the target power consumption, controllably switching the operational mode of the bi-directional converter to a first directional mode to direct current from the power rail into the capacitor bank.

Abstract: Provided herein are indole compounds that bind to BF3 of an androgen receptor (AR), which can modulate the AR for the treatment of Kennedy's disease

Abstract: The present invention provides processes for the preparation of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and novel intermediates used therein. In some embodiments the 3, 5-Dihydroxy-4-isopropyl-trans-stilbene is prepared from (E)-2-chloro-2-isopropyl-5-styrylcyclohexane-1,3-dione. Also disclosed are crystal forms of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and pharmaceutical compositions comprising same.

Abstract: A system for harnessing water pressure fluctuation includes an accumulator element, a pneumatic actuator, and an electrical generator. The accumulator element has a reception space for receiving water, a container space for containing air, and a flexible diaphragm to separate the water from the air. The pneumatic actuator has a cylindrical enclosure element and a piston rod element movable relative to the enclosure element. Pressure fluctuation in the water causes a pressure fluctuation in the air, which in turn causes movement of the piston rod element relative to the enclosure element. The system includes a crank shaft element to convert translational movement of the piston rod element into rotational movement of the shaft element. The crank shaft element is connected to the electrical generator. Movement of the piston rod element relative to the enclosure element causes rotational movement of the shaft element, which causes the generator to generate electrical power.

Abstract: Disclosed herein is a method of treating Idiopathic Pulmonary Fibrosis (IPF). The method includes administering to a subject in need thereof the deuterium-enriched pirfenidonc LYT-100 at a total daily dose from about 1650 mg to about 2500 mg.

Abstract: A brake test device and method for testing the braking system of a vehicle, to ensure compliance with safety regulations and ensure the braking system is functional, said brake test system including: i. at least one on/off switch; ii. at least one display; iii. at least one on/off status indicator; iv. at least one controller; v. at least one brake sensor; vi. at least one brake status indicator; vii. at least one throttle (or accelerator) sensor; viii. at least one throttle (or accelerator) status indicator; ix. at least one motor torque sensor; x. at least one motor torque status indicator; xi. at least one gear sensor; xii. at least one gear status indicator; xiii. at least one brake test status indicator; xiv. at least one data logging component to log data from a brake test; and xv. at least one communication component to communicate the data from the brake test.

Abstract: Systems and methods for providing a unified content experience that allows users to browse, search for, and stream multiples types of content from multiple media content providers are disclosed. Using the disclosed systems and methods, the media playback system can identify content available from the multiple content providers, aggregate and/or filter lists of available content, and present the aggregated content to users in a single interface without downloading, installing, and launching separate applications for each provider. Moreover, the user can select content from any one of the multiple sources for playback via the media playback system, including multiple content types, without downloading and installing separate applications for each provider.

Abstract: Provided herein are indole compounds that bind to BF3 of an androgen receptor (AR), which can modulate the AR for the treatment of Kennedy's disease

Abstract: Systems and methods for device integration in augmented reality environments are disclosed. For example, prior to an AR session being initiated, smart devices within a physical environment where the AR session is to be utilized may be identified and selected based on the functionality of the smart devices and the capabilities of an AR application associated with the AR session. Location information about the smart devices may also be determined and this information may be utilized to generate configuration data, which may be used by the AR application to cause device state transitions on the smart devices in response to events that occur in an AR environment of the AR session.

Abstract: A computerized method of delivering applications includes transmitting, by a connection server, a registration request to an application manager server, the registration request including administration credentials for the application manager server and a public certificate of the connection server, the administration credentials causing the application manager server to trust the connection server regarding application requests; receiving, by the connection server, a user application launch request from a user device, the user application launch request identifying an application; generating a proxy application launch request for the received user application launch request, the proxy application launch request identifying the application and including a signed message created with a private key associated with the public certificate; and transmitting the proxy application launch request for delivery to the application manager server, causing the application manager server to make the application available t

Abstract: A method for on-demand cell site inventory update retrieval in a telecommunications carrier network comprises receiving, by an inventory application, updated component data associated with one or more components in a cell site, wherein the updated component data comprises a most up-to-date version of data describing the one or more components, storing, in a memory, a master inventory including data regarding a plurality of components in each of the cell sites in the RAN, and updating, by the inventory application, in the master inventory, records associated with each of the one or more components to include the updated component data when the master inventory excludes the updated component data associated with the one or more components.

Abstract: A system for regulating speed of a vehicle along a road surface, the system including: at least one controller; at least one throttle sensor in communication with the at least one controller; at least one brake sensor in communication with the at least one controller; at least one gear sensor in communication with the at least one controller; at least one speed sensor in communication with the at least one controller; at least one motor in communication with the at least one controller; and at least one energy source in communication with the at least one controller and the at least one motor; wherein the at least one controller further includes a proportional integral and derivative controller; and at least one retardive braking system in communication with the at least one controller and controlled by the proportional integral and derivative controller.

Abstract: Some implementations relate to providing adaptive, distributed simulation of fluids with rigid body coupling. According to one aspect, a method simulates, with a coarse resolution on one or more server devices, a global flow field for a fluid within a virtual environment. The method determines regions within the grid to obtain additional detail for, based on the presence of one or more rigid objects within the virtual environment. For each region, the computer-implemented method: assigns client device(s) to the region; sends fluid simulation data pertaining to the region to the client devices; and receives refined fluid simulation data for the region from the client devices. The method replaces the fluid simulation data in the global fluid simulation pertaining to the regions with the refined fluid simulation data for the regions. The method then updates the global flow field for the fluid in real time based on the simulation data.

Abstract: An auto injector apparatus includes a prefilled syringe including a barrel and a needle disposed at the distal end of the barrel. A therapeutic fluid including fremanezumab is held within the barrel. A stopper is disposed within the barrel. The auto injector apparatus also includes an auto injector that holds the prefilled syringe. The auto injector includes a piston rod and an injection spring that drives the piston rod into abutment with the stopper to apply a dispensing force to the stopper.

Abstract: Some implementations relate to methods, systems, and computer-readable media for determining updated states of rigid body objects. In some implementations, the method includes receiving a model representation of rigid body objects, receiving an input state of the rigid body objects, determining that a relative velocity meets a threshold velocity, responsive to determining that a first rigid body object and a second rigid body object are in contact and that the relative velocity meets the threshold velocity, constructing a merged representation that represents the first rigid body object and the second rigid body object, applying a solver based on the input state and the merged representation to obtain an updated state for the first rigid body object and the second rigid body object, and causing the first rigid body object and the second rigid body object in the updated state to be displayed within a virtual environment.

Abstract: Some implementations relate to methods, systems, and computer-readable media to provide scalable soft body locomotion/animation for a virtual experience, such as a three-dimensional (3D) environment. In some implementations, the method includes building a control space having information representative of forces corresponding to natural movement of the soft body, wherein the soft body is part of a virtual environment, coupling the control space and a physical space to define a controller pipeline that performs animation of the soft body, performing the animation of the soft body using the controller pipeline, and causing the animation of the soft body to be displayed in a user interface of the virtual environment. Building the control space may comprise simulating the forces corresponding to the natural movement of the soft body by solving an elastodynamic optimization problem using auxiliary variables as degrees of freedom.