Abstract: An aerosol provision system (1) for generating an aerosol. The aerosol provision system comprises a first reservoir (31) for storing a first aerosol-generating material, wherein the aerosol provision system (1) is configured to generate a first aerosol using the first aerosol-generating material. The aerosol provision system 1 also comprises a second reservoir (101) for storing an active substance, or second aerosol-generating material such that the aerosol provision system (1) is configured to generate a second aerosol using the second aerosol-generating material. In this way, the first aerosol may be generated in a way which then allows the second aerosol, or active substance, to then be either added to, mixed with, and/or supplied alongside the first aerosol in a way which allows the user to effectively customise to what extent this first aerosol, which is delivered to the user, is supplemented with the second aerosol/active substance.

Abstract: A method for administering a dosage of Apixaban to a patient for the treatment or prevention of thrombosis, the method comprising: administering a dosage of Apixaban to the patient, wherein the dosage of apixaban is determined by: receiving patient data relating to a patient, wherein the patient data includes a kidney function metric of the patient; and processing, using one or more processors, the patient data with a dosage calculator to determine the dosage of Apixaban for the patient, wherein the dosage calculator is derived from a plasma level prediction model that predicts Apixaban drug plasma levels, and the dosage calculator determines the dosage for the patient based in part on the kidney function metric of the patient.

Abstract: The invention relates to a surgical implant (100) comprising an implant body (101) comprising a polyaryletherketone polymer material and a radio-opaque marker (107) seated with an interference fit in a bore formed in the body. The surgical implant may be manufactured by forming the polyaryletherketone body including the bore. for instance by drilling the body and inserting the marker into the bore.

Abstract: The present disclosure provides a fluid flow augmenting device to augment a fluid flow in any fluid circulation system without significant additional power consumption. The device includes an annular body extending along a longitudinal axis and defining an internal volume. The annular body includes a fluid inlet on one longitudinal end and a fluid outlet on another end and a first and second fluid directing structures. The first fluid directing structure receives a first fluid flow with a first fluid flow rate from a fluid source via the fluid inlet while the second fluid directing structure induces a second fluid flow with a second fluid flow rate from around the device to combine with the first fluid flow and generate an augmented fluid flow having an augmented fluid flow rate to be exhausted via the fluid outlet.

Abstract: A prosthetic heart valve configured to replace a native heart valve and having a support frame configured to be reshaped into an expanded form in order to receive and/or support an expandable prosthetic heart valve therein is disclosed, together with methods of using same. The prosthetic heart valve may be configured to have a generally rigid and/or expansion-resistant configuration when initially implanted to replace a native valve (or other prosthetic heart valve), but to assume a generally expanded form when subjected to an outward force such as that provided by a dilation balloon or other mechanical expander.

Abstract: A catheter includes a handle and an elongate member extending from the handle. The catheter may also include steering system coupled to the handle. The steering system may be configured to deflect at least a portion of the elongate member in at least one direction. The catheter may also include a locking mechanism configured to lock the portion of the elongate member in a deflected configuration, and a lever coupled to the handle. The lever may be configured to move from a first position to a second position to engage the locking mechanism. The lever may also be configured to be separably retained at least at one of the first position or the second position to prevent movement therebetween.

Abstract: Embodiments of the present disclosure relate to an arrangement for inductively supplying energy and a method for manufacturing the arrangement. The method includes: a transmitter coil being on-site embedded in or on top of a magnetizable asphalt mixture below a surface of a drivable civil structure and configured to provide a magnetic field to transfer energy to a receiver coil. The magnetizable asphalt mixture includes an asphalt binding substance and soft magnetic particles, and a volume fraction of the soft magnetic particles is not smaller than 35% of a total mixture volume of the magnetizable asphalt mixture.

Abstract: A system identifies a candidate time interval in programming media content for a playback of a media content along with the programming media content. The identification is based on an analysis of a request received from a client device. The media content is based on user intent information and a plurality of targeting parameters associated with a user. Based on a specified version of the programming media content currently played at the client device, the media content is modified. Personalized media content corresponding to the candidate time interval in the programming media content is generated based on the modified media content and one or more constraints associated with the user. The personalized media content is presented along with a modified display view of the programming media content at the candidate time interval.

Abstract: A method includes implementing, via an electronic controller of an aircraft, an extend command received by the electronic controller from a flight control computer to rotate a wingtip of a wing to a flight position. The method includes, in response to a first determination at the electronic controller that rotation of the wingtip stopped before the flight position during implementation of the extend command, sending a first notification signal to the flight control computer from the electronic controller to cause the aircraft to be grounded and to schedule maintenance of the aircraft. The first notification signal includes one or more first error codes. The first notification signal causes the maintenance to include wingtip-to-latch pin drop maintenance responsive to a determination of the electronic controller indicating that a first particular angle of the wingtip relative to a primary portion of the wing is in a latch pin interference range.

Abstract: A folding wingtip aircraft includes a wing that includes a primary portion and a wingtip. The folding wingtip aircraft includes a folding wingtip system configured to rotate the wingtip relative to the primary portion. The folding wingtip aircraft also includes a flight control computer. The flight control computer is configured to, in response to a first determination that a wingtip position of the wingtip is not in a folded position when a second determination indicates that a last completed command by the folding wingtip system was a fold command, set error codes for the folding wingtip system. The flight control computer is also configured to change a setting to indicate that the folding wingtip aircraft is grounded based on the error codes.

Abstract: A method of manufacturing a moulded article is disclosed. The method comprises forming a body comprising a polymer material. The method further comprises polishing a portion of the body with a polishing element to smooth at least one imperfection. The polishing element comprises a different polymer material to the polymer material of the body.

Abstract: Disclosed are systems and methods for document branching. In some embodiments, the method includes the steps of: obtaining a branch model associated with a set of related documents, the branch model comprising one or more branches, each branch of the one or more branches comprising a branch type and one or more nodes, the one or more branches comprising a primary branch associated with a primary document, the set of related documents comprising the primary document having a first document identifier; generating a secondary branch based upon a revision of the primary document, the secondary branch associated with a secondary document of the set of related documents, the secondary document having a second document identifier; and adding the secondary branch to the branch model.

Abstract: Optionally, a plurality of spacers 228 is arranged between the planar surface 120 of the interfacing arrangement 114 (or the top horizontal arm) and the seat arrangement 102, for permanently raising the seat arrangement 102 with respect to the interfacing arrangement 114. The spacers 228 can be implemented as rectangular or cylindrical solid blocks that can be fabricated from plastics materials, metals, metal alloys, polymers, ceramics, wood, composites and so forth. The spacers 228 can be fixed between the seat arrangement 102 and the top planar surface 120 of the top horizontal arm of the interfacing arrangement 114 such that height of the seat arrangement 102 relative to the footrest arrangement 116 is raised. For example, a plurality of metallic spacers is fixed between the seat arrangement 102 and the interface arrangement by a technician such as by welding the metallic spacers between the seat arrangement 102 and the interface arrangement.

Abstract: Disclosed are systems and methods for document branching. In some embodiments, the method includes the steps of: obtaining a branch model associated with a set of related documents, the branch model comprising one or more branches, each branch of the one or more branches comprising a branch type and one or more nodes, the one or more branches comprising a primary branch associated with a primary document, the set of related documents comprising the primary document having a first document identifier; generating a secondary branch based upon a revision of the primary document, the secondary branch associated with a secondary document of the set of related documents, the secondary document having a second document identifier; and adding the secondary branch to the branch model.

Abstract: Disclosed are systems and methods for document branching. In some embodiments, the method includes the steps of: obtaining a branch model associated with a set of related documents, the branch model comprising one or more branches, each branch of the one or more branches comprising a branch type and one or more nodes, the one or more branches comprising a primary branch associated with a primary document, the set of related documents comprising the primary document having a first document identifier; generating a secondary branch based upon a revision of the primary document, the secondary branch associated with a secondary document of the set of related documents, the secondary document having a second document identifier; and adding the secondary branch to the branch model.

Abstract: An integrated circuit (IC) including a semiconductor surface layer of a substrate including functional circuitry having circuit elements formed in the semiconductor surface layer configured together with a Metal-Insulator-Metal capacitor (MIM) capacitor on the semiconductor surface layer for realizing at least one circuit function. The MIM capacitor includes a multilevel bottom capacitor plate having an upper top surface, a lower top surface, and sidewall surfaces that connect the upper and lower top surfaces (e.g., a bottom plate layer on a three-dimensional (3D) layer or the bottom capacitor plate being a 3D bottom capacitor plate). At least one capacitor dielectric layer is on the bottom capacitor plate. A top capacitor plate is on the capacitor dielectric layer, and there are contacts through a pre-metal dielectric layer to contact the top capacitor plate and the bottom capacitor plate.

Abstract: A method and system for automating the de-icing/anti-icing of an aircraft that includes the generation of a treatment plan that incudes input from at least one weather source. The treatment plan may then be reviewed by a pilot to any updates. After being finalized, the treatment plan is distributed to at least one de-icing vehicle to perform the de-icing/anti-icing of the aircraft. During execution of the de-icing/anti-icing, real-time updates may be provided by the system to the pilot of the aircraft.

Abstract: A wall assembly is manufactured for supporting an exterior covering of a structure. The wall assembly includes a frame assembly including a top member and a bottom member spaced from the top member. The frame assembly further includes a plurality of vertical members spaced from each other and coupled to and extending between the top and bottom members. The plurality of vertical members each have an exterior surface configured to face an exterior of the structure. A rigid foam layer is directly coupled to the exterior surface of the plurality of vertical members. A sheathing layer is coupled to the rigid foam layer opposite the plurality of vertical members with the sheathing layer configured to receive the exterior covering.

Abstract: Disclosed are systems and methods for document branching. In some embodiments, the method includes the steps of: obtaining a branch model associated with a set of related documents, the branch model comprising one or more branches, each branch of the one or more branches comprising a branch type and one or more nodes, the one or more branches comprising a primary branch associated with a primary document, the set of related documents comprising the primary document having a first document identifier; generating a secondary branch based upon a revision of the primary document, the secondary branch associated with a secondary document of the set of related documents, the secondary document having a second document identifier; and adding the secondary branch to the branch model.

Abstract: In some embodiments, the method includes the steps of: obtaining a branch model associated with a set of related documents, the branch model comprising one or more branches, each branch of the one or more branches comprising a branch type and one or more nodes, the one or more branches comprising a primary branch associated with a primary document, the set of related documents comprising the primary document having a first document identifier; generating a secondary branch based upon a revision of the primary document, the secondary branch associated with a secondary document of the set of related documents, the secondary document having a second document identifier; and adding the secondary branch to the branch model.