Patents by Inventor Paul A. D'Orazio

Paul A. D'Orazio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9844271
    Abstract: An adjustable support apparatus including a base with horizontal support members is provided. The adjustable support apparatus includes a first upright support member of a first predetermined height that is supported at one end thereof on one of the horizontal support members, and an other end of the first upright support member has a first support that is generally parallel to the one of the horizontal support members. A second upright support member is supported at one end thereof on a second one of the horizontal support members, and an other end of the second upright support member has a second support that is generally parallel to the second one of the horizontal support members.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: December 19, 2017
    Assignee: O MY STANDING COMFORT LLC
    Inventors: William Zager, Paul D'Orazio
  • Publication number: 20170254771
    Abstract: The present invention pertains to a hemolysis sensor, a hemolysis sensor system and methods of utilizing the hemolysis sensor or hemolysis sensor system to monitor or detect hemolysis in a sample, such as a whole blood sample, a plasma sample, a serum sample or hemolyzed blood. The hemolysis sensor responds to extracellular hemoglobin levels, for example, extracellular hemoglobin in a whole blood sample as a method for detecting hemolysis in whole blood.
    Type: Application
    Filed: April 21, 2017
    Publication date: September 7, 2017
    Applicant: Instrumentation Laboratory Company
    Inventors: Shankar Balasubramanian, Paul D'Orazio
  • Patent number: 9658181
    Abstract: The present invention pertains to a hemolysis sensor, a hemolysis sensor system and methods of utilizing the hemolysis sensor or hemolysis sensor system to monitor or detect hemolysis in a sample, such as a whole blood sample, a plasma sample, a serum sample or hemolyzed blood. The hemolysis sensor responds to extracellular hemoglobin levels, for example, extracellular hemoglobin in a whole blood sample as a method for detecting hemolysis in whole blood.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: May 23, 2017
    Assignee: Instrumentation Laboratory Company
    Inventors: Shankar Balasubramanian, Paul D'Orazio
  • Publication number: 20160262545
    Abstract: An adjustable support apparatus including a base with horizontal support members is provided. The adjustable support apparatus includes a first upright support member of a first predetermined height that is supported at one end thereof on one of the horizontal support members, and an other end of the first upright support member has a first support that is generally parallel to the one of the horizontal support members. A second upright support member is supported at one end thereof on a second one of the horizontal support members, and an other end of the second upright support member has a second support that is generally parallel to the second one of the horizontal support members.
    Type: Application
    Filed: May 26, 2016
    Publication date: September 15, 2016
    Applicant: O MY STANDING COMFORT LLC
    Inventors: William ZAGER, Paul D'ORAZIO
  • Publication number: 20150164235
    Abstract: An adjustable support apparatus including a base with horizontal support members is provided. The adjustable support apparatus includes a first upright support member of a first predetermined height that is supported at one end thereof on one of the horizontal support members, and an other end of the first upright support member has a first support that is generally parallel to the one of the horizontal support members. A second upright support member is supported at one end thereof on a second one of the horizontal support members, and an other end of the second upright support member has a second support that is generally parallel to the second one of the horizontal support members.
    Type: Application
    Filed: December 11, 2014
    Publication date: June 18, 2015
    Inventors: William Zager, Paul D'Orazio
  • Publication number: 20140262831
    Abstract: The present invention pertains to a hemolysis sensor, a hemolysis sensor system and methods of utilizing the hemolysis sensor or hemolysis sensor system to monitor or detect hemolysis in a sample, such as a whole blood sample, a plasma sample, a serum sample or hemolyzed blood. The hemolysis sensor responds to extracellular hemoglobin levels, for example, extracellular hemoglobin in a whole blood sample as a method for detecting hemolysis in whole blood.
    Type: Application
    Filed: March 10, 2014
    Publication date: September 18, 2014
    Inventors: Shankar Balasubramanian, Paul D'Orazio
  • Patent number: 5773270
    Abstract: A system for electrochemical measurement of glucose concentration in an undiluted test sample, e.g. blood is provided containing a sensor including a three-layered contiguous membrane. The membrane has a thickness of 50 to 130 microns, and is composed of a 1 to 10 micron thick first layer, a 10 to 30 micron thick second layer having an average pore diameter of 15 nanometers and a 40 to 80 micron thick third layer containing glucose oxidase. The third layer is less dense than the first and second layers and the first layer is more dense than the second layer. The layers of the membrane are fused together such that no clear distinction can be made between the layers at the boundary. The sensor is calibrated in a standard glucose solution which includes catalase as a hydrogen peroxide scavenger, and the sensor has a response that is linear throughout the concentration range of glucose in an undiluted sample.
    Type: Grant
    Filed: May 17, 1994
    Date of Patent: June 30, 1998
    Assignee: Chiron Diagnostics Corporation
    Inventors: Paul A. D'Orazio, David Sogin
  • Patent number: 5770028
    Abstract: A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.
    Type: Grant
    Filed: December 19, 1996
    Date of Patent: June 23, 1998
    Assignee: Chiron Diagnostics Corporation
    Inventors: Thomas C. Maley, Mark W. Boden, Paul A. D'Orazio, Peter G. Edelman
  • Patent number: 5711868
    Abstract: A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.
    Type: Grant
    Filed: September 15, 1995
    Date of Patent: January 27, 1998
    Assignee: Chiron Diagnostics Corporatiion
    Inventors: Thomas C. Maley, Paul A. D'Orazio, Bonnie C. Dalzell, Peter G. Edelman, James E. Flaherty, Richard W. Mason, Robert R. McCaffrey
  • Patent number: 5667983
    Abstract: It has been found that imidazole and related buffers enhance the activity of certain preservatives, for example either (1) a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one or (2) 5-bromo-5-nitro-1,3-dioxane, that are used in clinical diagnostic reagents. It has also been found that these buffers and certain surfactants, such as BRIJ 700 and related hydrophilic surfactants, enhance the precision and accuracy of enzyme biosensors.
    Type: Grant
    Filed: October 24, 1994
    Date of Patent: September 16, 1997
    Assignee: Chiron Diagnostics Corporation
    Inventors: Allison L. Abel, Paul A. D'Orazio, Bonnie C. Dalzell, Robert R. McCaffrey, Laura S. Uretsky
  • Patent number: 5616222
    Abstract: A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.
    Type: Grant
    Filed: September 15, 1995
    Date of Patent: April 1, 1997
    Assignee: Chiron Diagnostics Corporation
    Inventors: Thomas C. Maley, Paul A. D'Orazio, Peter G. Edelman, John A. Zalenski
  • Patent number: 5601694
    Abstract: A solid shale, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.
    Type: Grant
    Filed: July 27, 1995
    Date of Patent: February 11, 1997
    Assignee: Ciba Corning Diagnostics Corp.
    Inventors: Thomas C. Maley, Paul A. D'Orazio, Bonnie C. Dalzell, Peter G. Edelman, James E. Flaherty, Richard W. Mason, Robert R. McCaffrey
  • Patent number: 5573647
    Abstract: A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.
    Type: Grant
    Filed: September 15, 1995
    Date of Patent: November 12, 1996
    Assignee: Ciba Corning Diagnostics Corp.
    Inventors: Thomas C. Maley, Mark W. Boden, Paul A. D'Orazio, Bonnie C. Dalzell, Peter G. Edelman, James E. Flaherty, Robert B. Green, Steven C. Lepke, Richard W. Mason, Robert R. McCaffrey, John A. Zalenski
  • Patent number: 5529676
    Abstract: A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.
    Type: Grant
    Filed: September 15, 1995
    Date of Patent: June 25, 1996
    Assignee: Ciba Corning Diagnostics Corp.
    Inventors: Thomas C. Maley, Mark W. Boden, Paul A. D'Orazio, Bonnie C. Dalzell, Peter G. Edelman, James E. Flaherty, Robert B. Green, Steven C. Lepke, Richard W. Mason, Robert R. McCaffrey, John A. Zalenski
  • Patent number: 5494562
    Abstract: A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.
    Type: Grant
    Filed: June 27, 1994
    Date of Patent: February 27, 1996
    Assignee: Ciba Corning Diagnostics Corp.
    Inventors: Thomas C. Maley, Paul A. D'Orazio, Bonnie C. Dalzell, Peter G. Edelman, James E. Flaherty, Richard W. Mason, Robert R. McCaffrey
  • Patent number: 4415666
    Abstract: A membrane for electrochemical analysis is described comprising a first, relatively dense and thin layer and a second, relatively porous thick layer, which thick layer has dispersed therethrough the enzyme, glucose oxidase. The process of making the membrane by casting two to three layers of cellulose acetate compositions is also described.
    Type: Grant
    Filed: November 5, 1981
    Date of Patent: November 15, 1983
    Assignee: Miles Laboratories, Inc.
    Inventors: Paul A. D'Orazio, Arthur R. Eddy, Jr., Eric J. Fogt, James E. Jones, Bruce J. Oberhardt
  • Patent number: D367014
    Type: Grant
    Filed: June 27, 1994
    Date of Patent: February 13, 1996
    Assignee: Ciba Corning Diagnostics Corp.
    Inventors: Paul A. D'Orazio, James E. Flaherty
  • Patent number: D367235
    Type: Grant
    Filed: June 27, 1994
    Date of Patent: February 20, 1996
    Assignee: Ciba Corning Diagnostics Corp.
    Inventors: Paul A. D'Orazio, James E. Flaherty
  • Patent number: D371749
    Type: Grant
    Filed: July 19, 1995
    Date of Patent: July 16, 1996
    Assignee: Ciba Corning Diagnostics Corp.
    Inventors: Paul A. D'Orazio, James E. Flaherty
  • Patent number: D372877
    Type: Grant
    Filed: July 19, 1995
    Date of Patent: August 20, 1996
    Assignee: Ciba Corning Diagnostics Corp.
    Inventors: Paul A. D'Orazio, James E. Flaherty