Patents by Inventor Paul A. D'Orazio
Paul A. D'Orazio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9844271Abstract: An adjustable support apparatus including a base with horizontal support members is provided. The adjustable support apparatus includes a first upright support member of a first predetermined height that is supported at one end thereof on one of the horizontal support members, and an other end of the first upright support member has a first support that is generally parallel to the one of the horizontal support members. A second upright support member is supported at one end thereof on a second one of the horizontal support members, and an other end of the second upright support member has a second support that is generally parallel to the second one of the horizontal support members.Type: GrantFiled: May 26, 2016Date of Patent: December 19, 2017Assignee: O MY STANDING COMFORT LLCInventors: William Zager, Paul D'Orazio
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Publication number: 20170254771Abstract: The present invention pertains to a hemolysis sensor, a hemolysis sensor system and methods of utilizing the hemolysis sensor or hemolysis sensor system to monitor or detect hemolysis in a sample, such as a whole blood sample, a plasma sample, a serum sample or hemolyzed blood. The hemolysis sensor responds to extracellular hemoglobin levels, for example, extracellular hemoglobin in a whole blood sample as a method for detecting hemolysis in whole blood.Type: ApplicationFiled: April 21, 2017Publication date: September 7, 2017Applicant: Instrumentation Laboratory CompanyInventors: Shankar Balasubramanian, Paul D'Orazio
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Patent number: 9658181Abstract: The present invention pertains to a hemolysis sensor, a hemolysis sensor system and methods of utilizing the hemolysis sensor or hemolysis sensor system to monitor or detect hemolysis in a sample, such as a whole blood sample, a plasma sample, a serum sample or hemolyzed blood. The hemolysis sensor responds to extracellular hemoglobin levels, for example, extracellular hemoglobin in a whole blood sample as a method for detecting hemolysis in whole blood.Type: GrantFiled: March 10, 2014Date of Patent: May 23, 2017Assignee: Instrumentation Laboratory CompanyInventors: Shankar Balasubramanian, Paul D'Orazio
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Publication number: 20160262545Abstract: An adjustable support apparatus including a base with horizontal support members is provided. The adjustable support apparatus includes a first upright support member of a first predetermined height that is supported at one end thereof on one of the horizontal support members, and an other end of the first upright support member has a first support that is generally parallel to the one of the horizontal support members. A second upright support member is supported at one end thereof on a second one of the horizontal support members, and an other end of the second upright support member has a second support that is generally parallel to the second one of the horizontal support members.Type: ApplicationFiled: May 26, 2016Publication date: September 15, 2016Applicant: O MY STANDING COMFORT LLCInventors: William ZAGER, Paul D'ORAZIO
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Publication number: 20150164235Abstract: An adjustable support apparatus including a base with horizontal support members is provided. The adjustable support apparatus includes a first upright support member of a first predetermined height that is supported at one end thereof on one of the horizontal support members, and an other end of the first upright support member has a first support that is generally parallel to the one of the horizontal support members. A second upright support member is supported at one end thereof on a second one of the horizontal support members, and an other end of the second upright support member has a second support that is generally parallel to the second one of the horizontal support members.Type: ApplicationFiled: December 11, 2014Publication date: June 18, 2015Inventors: William Zager, Paul D'Orazio
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Publication number: 20140262831Abstract: The present invention pertains to a hemolysis sensor, a hemolysis sensor system and methods of utilizing the hemolysis sensor or hemolysis sensor system to monitor or detect hemolysis in a sample, such as a whole blood sample, a plasma sample, a serum sample or hemolyzed blood. The hemolysis sensor responds to extracellular hemoglobin levels, for example, extracellular hemoglobin in a whole blood sample as a method for detecting hemolysis in whole blood.Type: ApplicationFiled: March 10, 2014Publication date: September 18, 2014Inventors: Shankar Balasubramanian, Paul D'Orazio
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Patent number: 5773270Abstract: A system for electrochemical measurement of glucose concentration in an undiluted test sample, e.g. blood is provided containing a sensor including a three-layered contiguous membrane. The membrane has a thickness of 50 to 130 microns, and is composed of a 1 to 10 micron thick first layer, a 10 to 30 micron thick second layer having an average pore diameter of 15 nanometers and a 40 to 80 micron thick third layer containing glucose oxidase. The third layer is less dense than the first and second layers and the first layer is more dense than the second layer. The layers of the membrane are fused together such that no clear distinction can be made between the layers at the boundary. The sensor is calibrated in a standard glucose solution which includes catalase as a hydrogen peroxide scavenger, and the sensor has a response that is linear throughout the concentration range of glucose in an undiluted sample.Type: GrantFiled: May 17, 1994Date of Patent: June 30, 1998Assignee: Chiron Diagnostics CorporationInventors: Paul A. D'Orazio, David Sogin
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Patent number: 5770028Abstract: A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.Type: GrantFiled: December 19, 1996Date of Patent: June 23, 1998Assignee: Chiron Diagnostics CorporationInventors: Thomas C. Maley, Mark W. Boden, Paul A. D'Orazio, Peter G. Edelman
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Patent number: 5711868Abstract: A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.Type: GrantFiled: September 15, 1995Date of Patent: January 27, 1998Assignee: Chiron Diagnostics CorporatiionInventors: Thomas C. Maley, Paul A. D'Orazio, Bonnie C. Dalzell, Peter G. Edelman, James E. Flaherty, Richard W. Mason, Robert R. McCaffrey
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Patent number: 5667983Abstract: It has been found that imidazole and related buffers enhance the activity of certain preservatives, for example either (1) a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one or (2) 5-bromo-5-nitro-1,3-dioxane, that are used in clinical diagnostic reagents. It has also been found that these buffers and certain surfactants, such as BRIJ 700 and related hydrophilic surfactants, enhance the precision and accuracy of enzyme biosensors.Type: GrantFiled: October 24, 1994Date of Patent: September 16, 1997Assignee: Chiron Diagnostics CorporationInventors: Allison L. Abel, Paul A. D'Orazio, Bonnie C. Dalzell, Robert R. McCaffrey, Laura S. Uretsky
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Patent number: 5616222Abstract: A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.Type: GrantFiled: September 15, 1995Date of Patent: April 1, 1997Assignee: Chiron Diagnostics CorporationInventors: Thomas C. Maley, Paul A. D'Orazio, Peter G. Edelman, John A. Zalenski
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Patent number: 5601694Abstract: A solid shale, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.Type: GrantFiled: July 27, 1995Date of Patent: February 11, 1997Assignee: Ciba Corning Diagnostics Corp.Inventors: Thomas C. Maley, Paul A. D'Orazio, Bonnie C. Dalzell, Peter G. Edelman, James E. Flaherty, Richard W. Mason, Robert R. McCaffrey
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Patent number: 5573647Abstract: A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.Type: GrantFiled: September 15, 1995Date of Patent: November 12, 1996Assignee: Ciba Corning Diagnostics Corp.Inventors: Thomas C. Maley, Mark W. Boden, Paul A. D'Orazio, Bonnie C. Dalzell, Peter G. Edelman, James E. Flaherty, Robert B. Green, Steven C. Lepke, Richard W. Mason, Robert R. McCaffrey, John A. Zalenski
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Patent number: 5529676Abstract: A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.Type: GrantFiled: September 15, 1995Date of Patent: June 25, 1996Assignee: Ciba Corning Diagnostics Corp.Inventors: Thomas C. Maley, Mark W. Boden, Paul A. D'Orazio, Bonnie C. Dalzell, Peter G. Edelman, James E. Flaherty, Robert B. Green, Steven C. Lepke, Richard W. Mason, Robert R. McCaffrey, John A. Zalenski
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Patent number: 5494562Abstract: A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.Type: GrantFiled: June 27, 1994Date of Patent: February 27, 1996Assignee: Ciba Corning Diagnostics Corp.Inventors: Thomas C. Maley, Paul A. D'Orazio, Bonnie C. Dalzell, Peter G. Edelman, James E. Flaherty, Richard W. Mason, Robert R. McCaffrey
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Patent number: 4415666Abstract: A membrane for electrochemical analysis is described comprising a first, relatively dense and thin layer and a second, relatively porous thick layer, which thick layer has dispersed therethrough the enzyme, glucose oxidase. The process of making the membrane by casting two to three layers of cellulose acetate compositions is also described.Type: GrantFiled: November 5, 1981Date of Patent: November 15, 1983Assignee: Miles Laboratories, Inc.Inventors: Paul A. D'Orazio, Arthur R. Eddy, Jr., Eric J. Fogt, James E. Jones, Bruce J. Oberhardt
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Patent number: D367014Type: GrantFiled: June 27, 1994Date of Patent: February 13, 1996Assignee: Ciba Corning Diagnostics Corp.Inventors: Paul A. D'Orazio, James E. Flaherty
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Patent number: D367235Type: GrantFiled: June 27, 1994Date of Patent: February 20, 1996Assignee: Ciba Corning Diagnostics Corp.Inventors: Paul A. D'Orazio, James E. Flaherty
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Patent number: D371749Type: GrantFiled: July 19, 1995Date of Patent: July 16, 1996Assignee: Ciba Corning Diagnostics Corp.Inventors: Paul A. D'Orazio, James E. Flaherty
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Patent number: D372877Type: GrantFiled: July 19, 1995Date of Patent: August 20, 1996Assignee: Ciba Corning Diagnostics Corp.Inventors: Paul A. D'Orazio, James E. Flaherty