Abstract: A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are defined herein, are useful as inhibitors of one or more Janus kinases. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient are disclosed.

Abstract: A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are defined herein, are useful as inhibitors of one or more Janus kinases. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient are disclosed.

Abstract: The invention provides JAK kinase inhibitors of Formula Ia, enantiomers, diasteriomers or pharmaceutically acceptable salts thereof, wherein R1, R2, R7 and Z are defined herein, a pharmaceutical composition that includes a compound of Formula Ia and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a JAK kinase activity in a patient.

Abstract: An ammunition cartridge casing having a geometry designed to allow for the use of polymeric materials in forming the walls of the cartridge casing of an ammunition article, and methods of reusing such cartridges are provided. More specifically, the ammunition cartridge has a specified ratio between the wall-thicknesses of select portions of an ammunition article's cartridge casing such that polymeric materials may be used in the construction of the ammunition article cartridge casings.

Abstract: A subsonic ammunition cartridge casing having an engineered internal volume designed to allow for the introduction of precisely the amount of propellant necessary at precisely the desired location to reproducibly produce the desired projectile velocity and internal pressure is provided. The subsonic shell casing has an engineered internal propellant cavity built into the internal body of the casing itself that does not necessarily depend on the introduction of a separate volume reducing device such as tubing, filler, foam filler and the like. This ensures the integrity of the case, does not result in anything being expelled through the muzzle of the weapon other than the projectile, does not have any burning or combusting components, allows for very precise control of the internal volume and thus chamber pressure, and is economical to produce.

Abstract: The invention provides JAK kinase inhibitors of Formula Ia, enantiomers, diasteriomers or pharmaceutically acceptable salts thereof, wherein R1, R2, R7 and Z are defined herein, a pharmaceutical composition that includes a compound of Formula Ia and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a JAK kinase activity in a patient.

Abstract: The invention provides novel compounds of formula I having the general formula: wherein R1, R2, R3, X and Y are as described herein. Accordingly, the compounds may be provided in pharmaceutically acceptable compositions and used for the treatment of immunological or hyperproliferative disorders.

Abstract: A joint prosthesis includes a head component that is engaged to a bone stem through a mounting element. The mounting element is configured for articulating engagement with the stem to permit angular positioning of the head component in multiple degrees of freedom. The mounting element is fastened to the stem by a press-fit engagement and a separate mechanical fastener.

Abstract: A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are defined herein, are useful as inhibitors of one or more Janus kinases. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient are disclosed.

Abstract: The invention provides JAK kinase inhibitors of Formula Ia, enantiomers, diasteriomers or pharmaceutically acceptable salts thereof, wherein R1, R2, R7 and Z are defined herein, a pharmaceutical composition that includes a compound of Formula Ia and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a JAK kinase activity in a patient.

Abstract: The invention provides novel compounds of formula I having the general formula: wherein R1, R2, R3, X and Y are as described herein. Accordingly, the compounds may be provided in pharmaceutically acceptable compositions and used for the treatment of immunological or hyperproliferative disorders.

Abstract: A method of transmitting multiple data segments of a disk image from a server to at least two clients that have differing disk image types, the method including the steps of the server: streaming multiple data segments forming at least part of two different disk image types to the clients, and interlacing data segments of a first image type with data segments of a second image type.

Abstract: An implantable marker, instruments for implanting the marker and method for implanting the marker are described. The implantable marker comprises a housing with an outer surface providing a bone anchor and having a cavity within which a marker detectable by a tracking system is secured. The kit includes a guide instrument having a guide channel for receiving an implantable marker, an insertion tool receivable within the channel and having a distal end for releasably engaging an implantable marker, and an implantable marker receivable within the channel. The insertion tool is operable to drive the implantable marker into the bone. The method includes puncturing the skin with an instrument, driving the implantable marker into the bone and withdrawing the instrument, leaving the marker implanted within the bone.

Abstract: An implantable marker, instruments for implanting the marker and method for implanting the marker are described. The implanta+e marker comprises a housing with an outer surface providing a bone anchor and having a cavity within which a marker detectable by a tracking system is secured. The kit includes a guide instrument having a guide channel for receiving an implanta+e marker, an insertion tool receivable within the channel and having a distal end for releasably engaging an implanta+e marker, and an implanta+e marker receiva+e within the channel. The insertion tool is operable to drive the implanta+e marker into the bone. The method includes puncturing the skin with an instrument, driving the implanta+e marker into the bone and withdrawing the instrument, leaving the marker implanted within the bone.

Abstract: A gun oil composition consisting essentially of: 2.0 to 15% by weight of isopropanol; 20 to 60% by weight of heptane or a petroleum distillate; 3 to 20% by weight of a mixture of viscosity modifiers, antioxidants and reducing agents including benzyl acetate, t-dibutyl-p-cresol, at least one alkyl succinic acid, at least one zinc alkyl thiophosphate, polymethacrylate, and methyl silicone polymer, wherein the alkyl is C1 to C6 alkyl; and the balance, lube oil bright stock to 100% by weight.

Abstract: A joint prosthesis includes a head component that is engaged to a bone stem through a mounting element. The mounting element is configured for articulating engagement with the stem to permit angular positioning of the head component in multiple degrees of freedom. The mounting element is fastened to the stem by a press-fit engagement and a separate mechanical fastener.