Patents by Inventor Paul A. Grieco

Paul A. Grieco has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL OPTICAL LABELING MOLECULES FOR PROTEOMICS AND OTHER BIOLOGICAL ANALYSIS
    Publication number: 20140186875
    Abstract: The invention relates to compositions and methods useful in the labeling and identification of changes in protein levels, changes in enzyme activity, and changes in protein modification. The invention provides for highly soluble optical labeling molecules which are optionally cleavable after separation of mixtures of labeled proteins into components. These optical labeling molecules find utility in a variety of applications, including use in the field of proteomics.
    Type: Application
    Filed: December 30, 2013
    Publication date: July 3, 2014
    Applicant: Montana State University
    Inventors: Edward Dratz, Paul Grieco
  • Zwitterionic dyes for labeling in proteomic and other biological analyses
    Patent number: 8197758
    Abstract: The invention relates to compositions and methods useful in the labeling and identification of proteins. The invention provides for highly soluble zwitterionic dye molecules where the dyes and associated side groups are non-titratable and maintain their net zwitterionic character over a broad pH range, for example, between pH 3 and 12. These dye molecules find utility in a variety of applications, including use in the field of proteomics.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: June 12, 2012
    Assignee: Montana State University
    Inventors: Edward A. Dratz, Paul A. Grieco
  • Zwitterionic dyes for labeling in proteomic and other biological analyses
    Patent number: 8197759
    Abstract: The invention relates to compositions and methods useful in the labeling and identification of proteins. The invention provides for highly soluble zwitterionic dye molecules where the dyes and associated side groups are non-titratable and maintain their net zwitterionic character over a broad pH range, for example, between pH 3 and 12. These dye molecules find utility in a variety of applications, including use in the field of proteomics.
    Type: Grant
    Filed: August 31, 2009
    Date of Patent: June 12, 2012
    Assignee: Montana State University
    Inventors: Edward A. Dratz, Paul A. Grieco
  • Zwitterionic dyes for labeling in proteomic and other biological analyses
    Patent number: 7833799
    Abstract: The invention relates to compositions and methods useful in the labeling and identification of proteins. The invention provides for highly soluble zwitterionic dye molecules where the dyes and associated side groups are non-titratable and maintain their net zwitterionic character over a broad pH range, for example, between pH 3 and 12. These dye molecules find utility in a variety of applications, including use in the field of proteomics.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: November 16, 2010
    Assignee: Montana State University
    Inventors: Edward A. Dratz, Paul A. Grieco
  • NOVEL OPTICAL LABELING MOLECULES FOR PROTEOMICS AND OTHER BIOLOGICAL ANALYSES
    Publication number: 20100252433
    Abstract: The invention relates to compositions and methods useful in the labeling and identification of changes in protein levels, changes in enzyme activity, and changes in protein modification. The invention provides for highly soluble optical labeling molecules which are optionally cleavable after separation of mixtures of labeled proteins into components. These optical labeling molecules find utility in a variety of applications, including use in the field of proteomics.
    Type: Application
    Filed: October 13, 2009
    Publication date: October 7, 2010
    Inventors: Edward DRATZ, Paul Grieco
  • NOVEL ZWITTERIONIC DYES FOR LABELING IN PROTEOMIC AND OTHER BIOLOGICAL ANAYLSES
    Publication number: 20100203645
    Abstract: The invention relates to compositions and methods useful in the labeling and identification of proteins. The invention provides for highly soluble zwitterionic dye molecules where the dyes and associated side groups are non-titratable and maintain their net zwitterionic character over a broad pH range, for example, between pH 3 and 12. These dye molecules find utility in a variety of applications, including use in the field of proteomics.
    Type: Application
    Filed: August 31, 2009
    Publication date: August 12, 2010
    Inventors: Edward A. DRATZ, Paul A. GRIECO
  • NOVEL ZWITTERIONIC DYES FOR LABELING IN PROTEOMIC AND OTHER BIOLOGICAL ANALYSES
    Publication number: 20100036133
    Abstract: The invention relates to compositions and methods useful in the labeling and identification of proteins. The invention provides for highly soluble zwitterionic dye molecules where the dyes and associated side groups are non-titratable and maintain their net zwitterionic character over a broad pH range, for example, between pH 3 and 12. These dye molecules find utility in a variety of applications, including use in the field of proteomics.
    Type: Application
    Filed: June 22, 2007
    Publication date: February 11, 2010
    Applicant: MONTANA STATE UNIVERSITY
    Inventors: Edward A. Dratz, Paul A. Grieco
  • Zwitterionic dyes for labeling in proteomic and other biological analyses
    Patent number: 7582260
    Abstract: The invention relates to compositions and methods useful in the labeling and identification of proteins. The invention provides for highly soluble zwitterionic dye molecules where the dyes and associated side groups are non-titratable and maintain their net zwitterionic character over a broad pH range, for example, between pH 3 and 12. These dye molecules find utility in a variety of applications, including use in the field of proteomics.
    Type: Grant
    Filed: January 20, 2004
    Date of Patent: September 1, 2009
    Assignee: Montana State University
    Inventors: Edward A. Dratz, Paul A. Grieco
  • NOVEL ZWITTERIONIC DYES FOR LABELING IN PROTEOMIC AND OTHER BIOLOGICAL ANALYSES
    Publication number: 20070259333
    Abstract: The invention relates to compositions and methods useful in the labeling and identification of proteins. The invention provides for highly soluble zwitterionic dye molecules where the dyes and associated side groups are non-titratable and maintain their net zwitterionic character over a broad pH range, for example, between pH 3 and 12. These dye molecules find utility in a variety of applications, including use in the field of proteomics.
    Type: Application
    Filed: June 22, 2007
    Publication date: November 8, 2007
    Applicant: MONTANA STATE UNIVERSITY
    Inventors: Edward Dratz, Paul Grieco
  • Novel zwitterionic dyes for labeling in proteomic and other biological analyses
    Publication number: 20040248203
    Abstract: The invention relates to compositions and methods useful in the labeling and identification of proteins. The invention provides for highly soluble zwitterionic dye molecules where the dyes and associated side groups are non-titratable and maintain their net zwitterionic character over a broad pH range, for example, between pH 3 and 12. These dye molecules find utility in a variety of applications, including use in the field of proteomics.
    Type: Application
    Filed: January 20, 2004
    Publication date: December 9, 2004
    Applicant: Montana State University
    Inventors: Edward A. Dratz, Paul A. Grieco
  • Novel zwitterionic fluorescent dyes for labeling in proteomic and other biological analyses
    Publication number: 20040106153
    Abstract: The invention relates to compositions and methods useful in the labeling and identification of proteins. The invention provides for highly soluble zwitterionic dye molecules where the dyes and associated side groups are non-titratable and maintain their net zwitterionic character over a broad pH range, for example, between pH 3 and 12. These dye molecules find utility in a variety of applications, including use in the field of proteomics.
    Type: Application
    Filed: July 18, 2003
    Publication date: June 3, 2004
    Applicant: Montana State University
    Inventors: Edward A. Dratz, Paul A. Grieco
  • Therapeutic quassinoid preparations with antineoplastic, antiviral, and herbistatic activity
    Publication number: 20030158088
    Abstract: The present invention includes purified and isolated quassinoids and synthetically derived quassinoid analogs based on a picrasane carbon skeleton. Novel sidechains at C-15 incorporating water solubilizing agents such as glycine are discussed. Therapeutic methods taking advantage of anticancer, antiviral, and herbistatic properties of these quassinoids are disclosed, including use against solid tumors and human immunodeficiency virus infected cells.
    Type: Application
    Filed: December 17, 2002
    Publication date: August 21, 2003
    Applicant: Advanced Research and Technology Institute, Inc.
    Inventors: Paul A. Grieco, D. James Morre, Thomas H. Corbett, Frederick A. Valeriote
  • Therapeutic quassinoid preparations with antineoplastic, antiviral, and herbistatic activity
    Patent number: 6573296
    Abstract: The present invention includes purified and isolated quassinoids and synthetically derived quassinoid analogs based on a picrasane carbon skeleton. Novel sidechains at C-15 incorporating water solubilizing agents such as glycine are discussed. Therapeutic methods taking advantage of anticancer, antiviral, and herbistatic properties of these quassinoids are disclosed, including use against solid tumors and human immunodeficiency virus infected cells.
    Type: Grant
    Filed: April 16, 1999
    Date of Patent: June 3, 2003
    Assignee: Advanced Research and Technology Institute, Inc.
    Inventors: Paul A. Grieco, D. James Morre, Thomas H. Corbett, Frederick A. Valeriote
  • THERAPEUTIC QUASSINOID PREPARATIONS WITH ANTINEOPLASTIC, ANTIVIRAL, AND HERBISTATIC ACTIVITY
    Publication number: 20020019439
    Abstract: The present invention includes purified and isolated quassinoids and synthetically derived quassinoid analogs based on a picrasane carbon skeleton. Novel sidechains at C-15 incorporating water solubilizing agents such as glycine are discussed. Therapeutic methods taking advantage of anticancer, antiviral, and herbistatic properties of these quassinoids are disclosed, including use against solid tumors and human immunodeficiency virus infected cells.
    Type: Application
    Filed: April 16, 1999
    Publication date: February 14, 2002
    Inventors: PAUL A. GRIECO, D. JAMES MORRE, THOMAS H. CORBETT, FREDERICK A. VALERIOTE
  • Therapeutic Quassinoid preparations with antineoplastic, antiviral, and herbistatic activity
    Patent number: 5965493
    Abstract: The present invention includes purified and isolated quassinoids and synthetically derived quassinoid analogs based on a picrasane carbon skeleton. Novel sidechains at C-15 incorporating water solubilizing agents such as glycine are discussed. Therapeutic methods taking advantage of anticancer, antiviral, and herbistatic properties of these quassinoids are disclosed, including use against solid tumors and human immunodeficiency virus infected cells.
    Type: Grant
    Filed: May 1, 1997
    Date of Patent: October 12, 1999
    Assignees: Advanced Research and Technology Institute, Inc., The Board of Governors of Wayne State University, Purdue Reseach Foundation
    Inventors: Paul A. Grieco, D. James Morre, Thomas H. Corbett, Frederick A. Valeriote
  • Therapeutic quassinoid preparations with antineoplastic antiviral, and herbistatic activity
    Patent number: 5849748
    Abstract: The present invention includes purified and isolated quassinoids and synthetically derived quassinoid analogs based on a picrasane carbon skeleton. Novel sidechains at C-15 incorporating water solubilizing agents such as glycine are discussed. Therapeutic methods taking advantage of anticancer, antiviral, and herbistatic properties of these quassinoids are disclosed, including use against solid tumors and human immunodeficiency virus infected cells.
    Type: Grant
    Filed: June 13, 1997
    Date of Patent: December 15, 1998
    Assignee: Advanced Research and Technology Institute, Inc.
    Inventors: Paul A. Grieco, D. James Morre, Thomas H. Corbett, Frederick A. Valeriote
  • Therapeutic quassinoid preparations with antineoplastic, antiviral, and herbistatic activity
    Patent number: 5639712
    Abstract: Quassinoid compounds, compositions, and methods of using them for treating cells and solid tumors, and inhibiting plant growth.
    Type: Grant
    Filed: November 4, 1994
    Date of Patent: June 17, 1997
    Assignees: Indiana University Foundation, Purdue Research Foundation, Bd. of Governors of Wayne State Univ.
    Inventors: Paul A. Grieco, D. James Morre, Thomas H. Corbett, Frederick A. Valeriote
  • 12,16-Difluoroprostaglandin F.sub.2 .alpha. compounds
    Patent number: 4699996
    Abstract: This invention relates to novel 12,16-difluoroprostaglandin F.sub.2.alpha. compounds having leuteolytic activity.
    Type: Grant
    Filed: February 18, 1986
    Date of Patent: October 13, 1987
    Inventor: Paul A. Grieco
  • Prostaglandin derivatives
    Patent number: 4284794
    Abstract: Prostaglandins substituted at the 12 position with fluorine. These compounds are useful for a variety of pharmaceutical purposes including use as antifertility agents.
    Type: Grant
    Filed: December 16, 1976
    Date of Patent: August 18, 1981
    Assignee: University of Pittsburgh
    Inventor: Paul A. Grieco