Abstract: A composition includes a target pharmaceutical or biological agent, a solution containing the target pharmaceutical or biological agent, and substrate that is soluble in the solution. The substrate is capable of being solidified via a solidification process and the solidification process causes the substrate to become physically or chemically cross-linked, vitrified, or crystallized. As a result of the solidification process, particles are formed. The target pharmaceutical or biological agent within the solution retains proper conformation to ultimately produce a desired effect.

Abstract: A composition includes a target pharmaceutical or biological agent, a solution containing the target pharmaceutical or biological agent, and substrate that is soluble in the solution. The substrate is capable of being solidified via a solidification process and the solidification process causes the substrate to become physically or chemically cross-linked, vitrified, or crystallized. As a result of the solidification process, particles are formed. The target pharmaceutical or biological agent within the solution retains proper conformation to ultimately produce a desired effect.

Abstract: A bearing assembly comprising a bearing cup having two ends, with a pair of outer raceways formed one adjacent each end of the bearing cup. A pair of bearing cones form a pair of inner raceways. Two rows of tapered roller bearings with each row received between one inner raceway and one outer raceway. A pair of wear rings are provided, each having a first axially inwardly directed end in engagement with an outwardly directed end of a bearing cone. A pair of seals each having a first end fitted into one into one of the bearing cup cylindrical counterbores. Each seal has a second end including a resilient element to form a seal with one of the wear rings. A second end of each wear ring is received in a cylindrical counterbore in each annular backing ring. A circular shroud is located radially outer and adjacent to one seal.

Abstract: A bearing assembly comprising a bearing cup having two ends, with a pair of outer raceways formed one adjacent each end of the bearing cup. A pair of bearing cones form a pair of inner raceways. Two rows of tapered roller bearings with each row received between one inner raceway and one outer raceway. A pair of wear rings are provided, each having a first axially inwardly directed end in engagement with an outwardly directed end of a bearing cone. A pair of seals each having a first end fitted into one into one of the bearing cup cylindrical counterbores. Each seal has a second end including a resilient element to form a seal with one of the wear rings. A second end of each wear ring is received in a cylindrical counterbore in each annular backing ring. A circular shroud is located radially outer and adjacent to one seal.

Abstract: A composition includes a target pharmaceutical or biological agent, a solution containing the target pharmaceutical or biological agent, and substrate that is soluble in the solution. The substrate is capable of being solidified via a solidification process and the solidification process causes the substrate to become physically or chemically cross-linked, vitrified, or crystallized. As a result of the solidification process, particles are formed. The target pharmaceutical or biological agent within the solution retains proper conformation to ultimately produce a desired effect.

Abstract: A novel assembly for a railcar axle bearing is presented. The assembly includes a backing ring affixed to the fillet of the journal of an axle and a locking ring for further affixing the backing ring the journal. The locking ring has an inboard end affixed to the dust guard of the axle and an outboard end for engaging the backing ring. The looking ring may include a resilient sealing ring.

Abstract: A bearing assembly is provided having a roller bearing with an inner raceway fitted around the journal portion of an axle. An outer raceway combines with the inner raceway to receive roller elements. A backing ring is centered to the shaft fillet. An annular wear ring is positioned between the inner race and the backing ring. An improved lubricant seal arrangement is provided between the wear ring and the supporting outer raceway, and includes a rotor, a seal, a slinger and, in some embodiments, a stator.

Abstract: A bearing assembly is provided having a roller bearing a cone forming an inner race fitted around the journal portion of an axle. A cup forms an outer raceway that combines with the inner raceway to receive roller elements. A backing ring is centered to the shaft fillet. Tapered roller elements are located between and contact the inner and outer raceways. A cage is comprised of an inner ring, and outer ring, and a plurality of pocket bars extend between the inner and outer rings. The pocket bars of the cage include a protrusion that is received in a groove in the cone.

Abstract: A bearing assembly is provided having a roller bearing with an inner raceway fitted around the journal portion of an axle. An outer raceway combines with the inner raceway to receive roller elements. An improved lubricant seal arrangement is provided between the wear ring and the supporting outer raceway comprising a stator element, a rotor element and a flinger element.

Abstract: A novel assembly for a railcar axle bearing is presented. The assembly includes a backing ring affixed to the fillet of the journal of an axle and a locking ring for further affixing the backing ring the journal. The locking ring has an inboard end affixed to the dust guard of the axle and an outboard end for engaging the backing ring.

Abstract: A novel two-piece backing ring assembly for a railcar axle is presented. The backing ring assembly has an annular body affixed to the fillet of the journal and a locking ring for further affixing the annular body into position on the journal. The locking ring has an inboard end affixed to the dust guard of the shaft and an outboard end for engaging a slot in the annular body. The locking ring assembly may be retrofitted to older generation railcar axles to increase the structural rigidity of the bearing assembly and minimize fretting wear caused by railcar axle deflection.

Abstract: A bearing assembly is presented having a novel lubricant sealing design that, in one embodiment, combines the sealing advantages of both a labyrinth-like seal in combination with a contact seal. The improved seal includes a non-rotating seal case working in closely spaced cooperation with a rotor to form a channel. The rotor is attached and turns with the shaft, inducing flow in the channel. Lubricant leakage is impeded by the tortuous fluid path formed by the convoluted channel of the labyrinth-like seal and the fluid shear forces developed by the turning shaft. Any lubricant leakage is further impeded by a resilient seal contacting the surface of the rotor and constricting the channel.

Abstract: A bearing assembly is provided having a roller bearing with an inner raceway fitted around the journal portion of an axle. An outer raceway combines with the inner raceway to receive roller elements. An improved lubricant seal arrangement is provided between the wear ring and the supporting outer raceway comprising a stator element, a rotor element and a flinger element.

Abstract: A bearing assembly is provided having a roller bearing a cone forming an inner race fitted around the journal portion of an axle. A cup forms an outer raceway that combines with the inner raceway to receive roller elements. A backing ring is centered to the shaft fillet. Tapered roller elements are located between and contact the inner and outer raceways. A cage is comprised of an inner ring, and outer ring, and a plurality of pocket bars extend between the inner and outer rings. The pocket bars of the cage include a protrusion that is received in a groove in the cone.

Abstract: A novel two-piece backing ring assembly for a railcar axle is presented. The backing ring assembly has an annular body affixed to the fillet of the journal and a locking ring for further affixing the annular body into position on the journal. The locking ring has an inboard end affixed to the dust guard of the shaft and an outboard end for engaging a slot in the annular body. The locking ring assembly may be retrofitted to older generation railcar axles to increase the structural rigidity of the bearing assembly and minimize fretting wear caused by railcar axle deflection.

Abstract: A bearing assembly is presented having a novel lubricant sealing design that, in one embodiment, combines the advantages of contacting and non-contacting dust seals to balance energy efficiency while still providing an effective method for contaminant exclusion. The contacting and non-contacting dust seals further arranged to maximize the service life of the dust seals and prolong the maintenance intervals required on the bearing assembly.

Abstract: A bearing assembly is presented having a novel lubricant sealing design that, in one embodiment, combines the sealing advantages of both a labyrinth-like seal in combination with a contact seal. The improved seal includes a non-rotating seal case working in closely spaced cooperation with a rotor to form a channel. The rotor is attached and turns with the shaft, inducing flow in the channel. Lubricant leakage is impeded by the tortuous fluid path formed by the convoluted channel of the labyrinth-like seal and the fluid shear forces developed by the turning shaft. Any lubricant leakage is further impeded by a resilient seal contacting the surface of the rotor and constricting the channel.

Abstract: A bearing assembly for mounting on a journal at the end of a shaft employs a seal wear ring disposed between the backing ring and the end face of the axially inwardly directed bearing cone, with the outer cylindrical surface of the seal wear ring cooperating with a resilient sealing element for sealing the bearing. The inner diameter of the seal wear ring is greater than the diameter of the shaft journal to provide a clearance there between along the full length of the wear ring. Counterbores are provided in an outwardly directed surface of the backing ring and in the axially inwardly directed end face of the bearing cone, with the counterbores in the backing ring and bearing cone being dimensioned to provide an interference fit sufficient to provide a substantial radially compressive load in the ends of the seal wear ring upon assembly of the bearing.

Abstract: A sealed shaft bearing assembly employs a lubricant seal having a rigid seal case supporting a resilient dust seal in rubbing contact with a cylindrical surface on the shaft, and a labyrinth type primary seal between the dust seal and the interior of the seal case, with the labyrinth being defined by a stator mounted on the seal case and a rotor mounted for rotation with the shaft, and with the stator including a cylindrical tubular portion defining an elongated thin annular gap with the shaft cylindrical surface and the rotor defining an elongated thin annular gap with the outer surface of the rotor. The radial thickness and axial lengths of the thin annular gaps are such as to preclude the passage of grease type lubricant therethrough upon operation of the bearing.