Abstract: The present invention relates to multimers of polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. The invention also describes the multimerization of polypeptides through various chemical linkers and hinges of various lengths and rigidity using different sites of attachments within polypeptides. In particular, the invention describes multimers of peptides which are high affinity binders of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), particularly the spike protein S1 of SARS-CoV-2. The invention also includes pharmaceutical compositions comprising said polypeptides and to the use of said polypeptides in suppressing or treating a disease or disorder mediated by infection of SARS-CoV-2 or for providing prophylaxis to a subject at risk of infection of SARS-CoV-2.

Abstract: The present invention relates to multimers of polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. The invention also describes the multimerization of polypeptides through various chemical linkers and hinges of various lengths and rigidity using different sites of attachments within polypeptides. In particular, the invention describes multimers of peptides which are high affinity binders of ACE2. The invention also includes pharmaceutical compositions comprising said polypeptides and to the use of said polypeptides in suppressing or treating a disease or disorder mediated by ACE2, such as infection of COVID-19 or for providing prophylaxis to a subject at risk of infection of COVID-19.

Abstract: The present invention relates to multimers of polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. The invention also describes the multimerization of polypeptides through various chemical linkers and hinges of various lengths and rigidity using different sites of attachments within polypeptides. In particular, the invention describes multimers of peptides which are high affinity binders of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), particularly the spike protein S1 of SARS-CoV-2. The invention also includes pharmaceutical compositions comprising said polypeptides and to the use of said polypeptides in suppressing or treating a disease or disorder mediated by infection of SARS-CoV-2 or for providing prophylaxis to a subject at risk of infection of SARS-CoV-2.

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of the COVID-19 nucleocapsid protein (N-protein). The invention also includes pharmaceutical compositions comprising said polypeptides and to the use of said polypeptides in suppressing or treating a disease or disorder mediated by the COVID-19 nucleocapsid protein (N-protein), such as infection of COVID-19 or for providing prophylaxis to a subject at risk of infection of COVID-19.

Abstract: An HVAC Integrated electronic Module (HIM) (41) for controlling airflow through an HVAC module (12), the HVAC module including a variable speed blower motor (18), a plurality of airflow doors (26–28) for controlling air direction and hot-cold air temperature blend, and electrical actuators, servo motors or stepper motors for said doors, the HIM including: one or more air temperature sensors (22) for measurement of one or more of intake air temperature, outlet air temperature, air-off evaporator temperature and engine coolant temperature; actuator control circuitry (31) for controlling said electrical actuators, servo motors or stepper motors; blower motor speed control circuitry (15) for speed control of the variable speed blower motor; sensor control circuitry for said sensors; and communication circuitry for a serial communication interface (42) to enable communication with a vehicle users interface (32).

Abstract: An HVAC Integrated electronic Module (HIM) (41) for controlling airflow through an HVAC module (12), the HVAC module including a variable speed blower motor (18), a plurality of airflow doors (26-28) for controlling air direction and hot-cold air temperature blend, and electrical actuators, servo motors or stepper motors for said doors, the HIM including: one or more air temperature sensors (22) for measurement of one or more of intake air temperature, outlet air temperature, air-off evaporator temperature and engine coolant temperature; actuator control circuitry (31) for controlling said electrical actuators, servo motors or stepper motors; blower motor speed control circuitry (15) for speed control of the variable speed blower motor; sensor control circuitry for said sensors; and communication circuitry for a serial communication interface (42) to enable communication with a vehicle users interface (32).