Patents by Inventor Paul A. Klonowski

Paul A. Klonowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human aggrecanase and nucleic acid compositions encoding the same
    Patent number: 7094591
    Abstract: Human aggrecanase and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications. Also provided are methods of inhibiting aggrecanase activity in a host and methods of treating disease conditions associated with aggrecanase activity, e.g. rheumatoid arthritis, osteo-arthritis, infectious arthritis, gouty arthritis, psoriatic arthritis, spondolysis, sports injury, joint trauma, pulmonary disease, fibrosis, and the like.
    Type: Grant
    Filed: September 17, 2003
    Date of Patent: August 22, 2006
    Assignee: Syntex (U.S.A.) LLC
    Inventors: John David Allard, Renu Anand Heller, Paul Klonowski, Harold Edgar Van Wart
  • Human aggrecanase and nucleic acid compositions encoding the same
    Publication number: 20050100916
    Abstract: Human aggrecanase and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications. Also provided are methods of inhibiting aggrecanase activity in a host and methods of treating disease conditions associated with aggrecanase activity, e.g. rheumatoid arthritis, osteo-arthritis, infectious arthritis, gouty arthritis, psoriatic arthritis, spondolysis, sports injury, joint trauma, pulmonary disease, fibrosis, and the like.
    Type: Application
    Filed: September 17, 2003
    Publication date: May 12, 2005
    Inventors: John Allard, Renu Heller, Paul Klonowski, Harold Van Wart
  • Human aggrecanase and nucleic acid compositions encoding the same
    Patent number: 6649377
    Abstract: Human aggrecanase and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications. Also provided are methods of inhibiting aggrecanase activity in a host and methods of treating disease conditions associated with aggrecanase activity, e.g. rheumatoid arthritis, osteo-arthritis, infectious arthritis, gouty arthritis, psoriatic arthritis, spondolysis, sports injury, joint trauma, pulmonary disease, fibrosis, and the like.
    Type: Grant
    Filed: May 9, 2000
    Date of Patent: November 18, 2003
    Assignee: Syntex (U.S.A.) LLC
    Inventors: John David Allard, Renu Anand Ileller, Paul Klonowski, Harold Edgar VanWart
  • Novel metalloproteases having thrombospondin domains and nucleic acid compositions encoding the same
    Publication number: 20020107361
    Abstract: Novel metalloproteases having thrombospondin domain(s) (MPTS proteins) and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including diagnostic applications, therapeutic agent screening applications, as well as therapeutic applications for a variety of different conditions. Also provided are methods of treating disease conditions associated with aggrecanase activity, e.g. conditions characterized by the presence of aggrecan cleavage products, such as rheumatoid- and osteo-arthritis.
    Type: Application
    Filed: February 16, 2001
    Publication date: August 8, 2002
    Inventors: Renu Anand Heller, Fengrong Zuo, Paul Klonowski
  • Oligonucleotides specific for the MOMP gene sequence and methods for the detection of Chlamydia trachomatis
    Patent number: 5846785
    Abstract: The present invention relates to oligonucleotide probes useful in detecting, e.g. by hybridization or the ligase chain reaction, Chlamydia trachomatis DNA in the presence of other related DNA. The present invention is also directed to methods of detecting Chlamydia trachomatis organisms in a sample using the ligase chain reaction.
    Type: Grant
    Filed: June 23, 1997
    Date of Patent: December 8, 1998
    Assignee: Abbott Laboratories
    Inventors: John D. Burczak, John J. Carrino, Paul A. Klonowski, Matthew T. Manlove, Ronald L. Marshall, Edward K. Pabich, John A. Salituro
  • Oligonucleotides and methods for the detection of Chlamydia trachomatis
    Patent number: 5756298
    Abstract: The present invention relates to oligonucleotide probes useful in detecting, e.g. by hybridization or the ligase chain reaction, Chlamydia trachomatis DNA in the presence of other related DNA. The present invention is also directed to methods of detecting Chlamydia trachomatis organisms in a sample using the ligase chain reaction.
    Type: Grant
    Filed: September 5, 1996
    Date of Patent: May 26, 1998
    Assignee: Abbott Laboratories
    Inventors: John D. Burczak, John J. Carrino, Paul A. Klonowski, Matthew T. Manlove, Ronald L. Marshall, Edward K. Pabich, John A. Salituro
  • Oligonucleotides and methods for the detection of chlamydia trachomatis
    Patent number: 5601978
    Abstract: The present invention relates to oligonucleotide probes useful in detecting, e.g. by hybridization or the ligase chain reaction, Chlamydia trachomatis DNA in the presence of other related DNA. The present invention is also directed to methods of detecting Chlamydia trachomatis organisms in a sample using the ligase chain reaction.
    Type: Grant
    Filed: September 3, 1993
    Date of Patent: February 11, 1997
    Assignee: Abbott Laboratories
    Inventors: John D. Burczak, John J. Carrino, Paul A. Klonowski, Matthew T. Manlove, Ronald L. Marshall, Edward K. Pabich, John A. Salituro