Patents by Inventor Paul A. Krieg

Paul A. Krieg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for modulating angiogenesis with apelin compositions
    Patent number: 7736646
    Abstract: Novel methods of inhibiting angiogenesis or tumorigenesis with compositions that inhibit the apelin/APJ signaling pathway are provided. Also provided are methods of promoting angiogenesis or tumorigenesis with compositions comprising an apelin polypeptide or small molecule agonist. The present invention further provides methods for identifying therapeutic agents that affect angiogenesis.
    Type: Grant
    Filed: March 12, 2004
    Date of Patent: June 15, 2010
    Assignee: Arizona Board of Regents on behalf of the University of Arizona
    Inventor: Paul A. Krieg
  • Methods for modulating angiogenesis, lymphangiogenesis, and apoptosis with apelin compositions
    Publication number: 20060159676
    Abstract: Novel methods of inhibiting angiogenesis, lymphangiogenesis, tumorigenesis, inflammation, or metastasis, or promoting apoptosis with compositions that inhibit the apelin/APJ signaling pathway are provided. Also provided are methods of promoting angiogenesis or lymphangiogenesis, or inhibiting apoptosis with compositions comprising an apelin polypeptide or small molecule agonist. The present invention further provides methods for identifying therapeutic agents that affect angiogenesis, lymphangiogenesis, and/or apoptosis.
    Type: Application
    Filed: January 17, 2006
    Publication date: July 20, 2006
    Inventor: Paul Krieg
  • Methods for modulating angiogenesis and apoptosis with apelin compositions
    Publication number: 20060045880
    Abstract: Novel methods of inhibiting angiogenesis or tumorigenesis or promoting apoptosis with compositions that inhibit the apelin/APJ signaling pathway are provided. Also provided are methods of promoting angiogenesis or inhibiting apoptosis with compositions comprising an apelin polypeptide or small molecule agonist. The present invention further provides methods for identifying therapeutic agents that affect angiogenesis and/or apoptosis.
    Type: Application
    Filed: August 23, 2005
    Publication date: March 2, 2006
    Inventor: Paul Krieg
  • Methods for modulating angiogenesis with apelin compositions
    Publication number: 20040219152
    Abstract: Novel methods of inhibiting angiogenesis or tumorigenesis with compositions that inhibit the apelin/APJ signaling pathway are provided. Also provided are methods of promoting angiogenesis or tumorigenesis with compositions comprising an apelin polypeptide or small molecule agonist. The present invention further provides methods for identifying therapeutic agents that affect angiogenesis.
    Type: Application
    Filed: March 12, 2004
    Publication date: November 4, 2004
    Inventor: Paul A. Krieg
  • Dispensing mechanism with dual function flow regulator and sealing plate
    Patent number: 6257464
    Abstract: A flow regulator for controlling the flow of material from a container is disclosed, wherein the container includes a container outlet through which the material freely flows when the container outlet is not closed. The flow regulator is biased in a closed position, but is moveable to an open position to provide for material flow from the container. The flow regulator may be progressively moved to permit varying degrees of material flow as the opening in the container is progressively opened. The flow regulator provides both a closure to obstruct material flow and a seal to preserve the container contents from outside contamination or degradation. The flow regulator is disclosed in combination with a bulk bin container to form a novel dispensing mechanism.
    Type: Grant
    Filed: December 7, 1998
    Date of Patent: July 10, 2001
    Assignee: The Procter & Gamble Company
    Inventors: David Andrew Dalton, Eric Francis Henry, Brian Paul Krieg