Patents by Inventor Paul A. Lartey
Paul A. Lartey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5834438Abstract: 4"-Deoxy derivatives of erythromycin having the Formula (I) ##STR1## and pharmaceutically acceptable salts thereof, which are enhancers of gastric motility but have minimal antibacterial activity, as well as pharmaceutical compositions containing the same and methods for their use and preparation.Type: GrantFiled: May 4, 1995Date of Patent: November 10, 1998Assignee: Abbott LaboratoriesInventors: Paul A. Lartey, Larry L. Klein, Ramin Faghih, Hugh N. Nellans
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Patent number: 5789591Abstract: A process for preparing a compound having the formula: ##STR1## wherein R is selected from the group consisting of C.sub.3 -C.sub.6 -cycloalkyl, C.sub.3 -C.sub.6 -cycloalkylmethyl, C.sub.1 -C.sub.6 -alkyl, allyl and 2-methoxyethyl, by reacting: ##STR2## under defined conditions with subsequent stepwise reactions of the respective intermediate compounds with a malonic acid diester, POCl.sub.3, and by heating the final intermediate in a high boiling solvent.Type: GrantFiled: October 23, 1996Date of Patent: August 4, 1998Assignee: Abbott LaboratoriesInventors: Daniel T. Chu, David Allen Degoey, David J. Grampovnik, Larry Lewis Klein, Paul A. Lartey, Christina Louise Leone, Sheela Albert Thomas, Ming Clinton Yeung
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Patent number: 5773421Abstract: Novel antifungal agents having the formula: ##STR1## wherein R is hydrogen or --C(O)--R.sub.1 wherein R.sub.1 is alkenyl, C.sub.2 -C.sub.12 -alkyl, aryl, arylalkenyl, arylalkyl, aryl-aryl-, arylalkoxy-aryl-, aryloxyl-aryl-, aryl-aryl-aryl- or arylalkoxy-aryl-aryl-, or pharmaceutically acceptable salts, esters or prodrugs thereof, as well as (i) pharmaceutical compositions comprising such compounds, (ii) methods of treatment using such compounds, and (iv) methods and fungal cultures useful in making the same.Type: GrantFiled: December 21, 1995Date of Patent: June 30, 1998Assignee: Abbott LaboratoriesInventors: Lisa A. Alder, Marianna Jackson, Neal S. Burres, James B. McAlpine, Jill E. Hochlowski, Larry L. Klein, Paul A. Lartey, Clinton Yeung
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Patent number: 5712253Abstract: Novel macrocyclic 13-membered ring-contracted compounds derived from erythromycins A and B having the Formula (I) ##STR1## and pharmaceutically acceptable salts thereof, wherein R, R.sup.1, R.sup.2, R.sup.3 and X are specifically defined, having use in treating gastrointestinal disorders associated with hypermotilinemia, pharmaceutical compositions thereof, a method of treating gastrointestinal disorders associated with hypermotilinemia with said pharmaceutical compositions, and processes for the preparation thereof.Type: GrantFiled: June 18, 1996Date of Patent: January 27, 1998Assignee: Abbott LaboratoriesInventors: Paul A. Lartey, Cynthia Burnell Curty, Ramin Faghih, Hugh Nerby Nellans, Albert Christian Petersen
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Patent number: 5696084Abstract: Disclosed are novel antifungal agents having the formula: ##STR1## or a pharmaceutically acceptable acid, ester or prodrug thereof, wherein preferred compounds include those compounds wherein R.sub.1 is selected from the group consisting of --NH.sub.2 ; R.sub.2 is selected from the group consisting of hydrogen, fluoro, and hydroxyl; R.sub.3 is selected from the group consisting of --CH.sub.2 (p-C.sub.6 H.sub.4).sub.3 O(CH.sub.2).sub.3 CH.sub.3, --CH.sub.2 (p-C.sub.6 H.sub.4)O(CH.sub.2).sub.6 CH.sub.3, --COO(p-C.sub.6 H.sub.4)O(CH.sub.2).sub.6 CH.sub.3, --CO(Piperazinyl)(p-C.sub.6 H.sub.4).sub.2 OCH.sub.3, --CO(p-C.sub.6 H.sub.4)O(CH.sub.2).sub.6 CH.sub.3, --CO(p-C.sub.6 H.sub.4)(Piperazinyl)(p-C.sub.6 H.sub.4)O(CH.sub.2).sub.4 CH.sub.3, --CO(p-C.sub.6 H.sub.4)(Piperazinyl)(p-C.sub.6 H.sub.4)O(CH.sub.2).sub.6 CH.sub.3, --CO(p-C.sub.6 H.sub.4)(Piperazinyl)(p-C.sub.6 H.sub.4)OCH.sub.3, and --CO(p-C.sub.6 H.sub.4)(Piperazinyl)O(CH.sub.2).sub.6 CH.sub.3 ; and R.sub.Type: GrantFiled: August 16, 1996Date of Patent: December 9, 1997Assignee: Abbott LaboratoriesInventors: Paul A. Lartey, Leping Li, Larry Lewis Klein, Christina Louise Leone, Sheela Albert Thomas, Ming Clinton Yeung, David Allen Degoey, David J. Grampovnik
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Patent number: 5654411Abstract: 4"-Deoxy derivatives of erythromycin having the Formula (I) ##STR1## and pharmaceutically acceptable salts thereof, which are enhancers of gastric motility but have minimal antibacterial activity, as well as pharmaceutical compositions containing the same and methods for their use and preparation.Type: GrantFiled: May 4, 1995Date of Patent: August 5, 1997Assignee: Abbott LaboratoriesInventors: Paul A. Lartey, Larry L. Klein, Ramin Faghih, Hugh N. Nellans
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Patent number: 5578579Abstract: 4"-Deoxy derivatives of erythromycin having the Formula (I) ##STR1## and pharmaceutically acceptable salts thereof, which are enhancers of gastric motility but have minimal antibacterial activity, as well as pharmaceutical compositions containing the same and methods for their use and preparation.Type: GrantFiled: August 2, 1994Date of Patent: November 26, 1996Assignee: Abbott LaboratoriesInventors: Paul A. Lartey, Larry L. Klein, Ramin Faghih, Hugh N. Nellans
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Patent number: 5393743Abstract: Antibacterial compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein Y is selected from ##STR2## and X is selected from the group consisting of --C(O)--, --C(S)--, --CH.sub.2 --, --CH.sub.2 CH.sub.2 -- and --C(CH.sub.3).sub.2 --; also disclosed are processes and intermediates useful in the preparation of the above compounds, as well as compositions containing the same and methods for their use.Type: GrantFiled: July 6, 1993Date of Patent: February 28, 1995Assignee: Abbott LaboratoriesInventors: Carla Edwards, Paul A. Lartey
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Patent number: 5217960Abstract: Antibacterial compounds are disclosed having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein R.sup.1 is --NR.sup.4 R.sup.6, where R.sup.4 and R.sup.6 are independently selected from the group consisting of hydrogen, loweralkyl and arylalkyl or, together, R.sup.4 and R.sup.6 form a nitrogen-containing heterocycle attached at the nitrogen atom; R.sup.2 is selected from the group consisting of hydrogen, --OH and, when R.sup.3 is methylene, oxygen so as to form an epoxide; and R.sup.3 is selected from the group consisting of --CH.sub.2 OH, --NR.sup.4 R.sup.6, --(CH.sub.2).sub.n NR.sup.4 R.sup.6 and, when R.sup.2 is oxygen, methylene so as to form an epoxide, where n is 1-4 and R.sup.4 and R.sup.6 are as previously defined, with the proviso that when R.sup.2 is --OH, R.sup.3 may not be --NR.sup.4 R.sup.6 ; or R.sup.2 and R.sup.3 together are.dbd.CH.sub.2.Type: GrantFiled: May 3, 1991Date of Patent: June 8, 1993Assignee: Abbott LaboratoriesInventors: Paul A. Lartey, Ramin Faghih, Shari DeNinno
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Patent number: 5140014Abstract: The present invention is directed to the production and utilization of novel antibiotic compounds. These compounds are derivatives of the antibacterial agents tylosin and rosaramicin and exert a broad spectrum antibiotic activity toward several bacterial strains. Pharmaceutical compositions and methods of treating bacterial infections are described.Type: GrantFiled: November 13, 1989Date of Patent: August 18, 1992Assignee: Abbott LaboratoriesInventors: Clarence J. Maring, Paul A. Lartey, Leslie A. Freiberg
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Patent number: 5075289Abstract: Semisynthetic antibiotics with improved therapeutic properties are disclosed. In particular, 9-R-azacyclic derivatives of erythromycin, its derivatives, and their salts and esters show superior antimicrobial activity compared to other macrolide compounds.Type: GrantFiled: June 7, 1988Date of Patent: December 24, 1991Assignee: Abbott LaboratoriesInventors: Richard J. Pariza, Paul A. Lartey, Clarence J. Maring, Larry L. Klein
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Patent number: 4613589Abstract: Derivatives of 3-deoxy-D-manno-2-octulosonic acid (KDO) are potent inhibitors of bacterial enzymes and a novel class of antibacterial agents.Type: GrantFiled: August 19, 1985Date of Patent: September 23, 1986Assignee: Abbott LaboratoriesInventors: William Rosenbrook, Paul A. Lartey, David A. Riley
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Patent number: 4613590Abstract: Aminodeoxy derivatives of 3-deoxy-D-manno-2-octulosonic acid (KDO) are potent inhibitors of bacterial enzymes and a novel class of antibacterial agents.Type: GrantFiled: August 19, 1985Date of Patent: September 23, 1986Assignee: Abbott LaboratoriesInventors: William Rosenbrook, Paul A. Lartey, David A. Riley
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Patent number: 4242503Abstract: Described is a method of O-demethylating a fortimicin compound using hydriodic acid or tri-methylsilyiodide as an O-demethylating agent.Type: GrantFiled: March 29, 1979Date of Patent: December 30, 1980Assignee: Abbott LaboratoriesInventors: Paul A. Lartey, David J. Grampovnik