Abstract: Novel tetrahydroisoquinoline derivative compounds are disclosed herein that may be used as an active ingredient for a pharmaceutical composition, and in particular, for a pharmaceutical composition useful for preventing or treating a disease or condition responsive to modulation of the contractility of the skeletal sarcomere. This may be accomplished, for example, by modulation of the troponin complex of the fast skeletal muscle sarcomere through one or more of fast skeletal myosin, actin, tropomyosin, troponin C, troponin I, and troponin T, and fragments and isoforms thereof. The tetrahydroisoquinoline derivative compounds can thus be used as an agent for preventing or treating 1) neuromuscular disorders, 2) disorders of voluntary muscle, 3) CNS disorders in which muscle weakness, atrophy, and fatigue are prominent symptoms, 4) muscle symptoms stemming from systemic disorders, and 5) dysfunctions of pelvic floor and urethral/anal sphincter muscle.

Abstract: A cationic-stabilized dispersion for use in fabricating an in-mold coated article including at least one of a cationic-stabilized polyurethane dispersion, a cationic-stabilized acrylic dispersion, a cationic-stabilized polyacrylamide dispersion, a cationic-stabilized polyallylamine dispersion, a cationic-stabilized polyetheramine dispersion, and a cationic-stabilized chitosan dispersion.

Abstract: Device for harvesting direct sunlight, transmitting diffuse sunlight and for scattering light from a light source to provide illumination, including: a receiving layer including at least one solar energy collector and at least one light source; at least one optical component disposed on a first side of the receiving layer, the optical component including at least one plano-convex refracting element; a second optical component disposed on a second side of the receiving layer, the second optical component comprising at least one optical element; wherein the at least one plano-convex element is positioned to receive direct light and refract it towards the at least one optical element of the second optical component, and wherein the optical element is positioned to reflect light towards the solar energy collector; wherein the at least one optical element is positioned to refract and emit indirect light impinging thereon towards the exterior of the apparatus.

Abstract: Examples described herein emulate a processing architecture using multiple translations of the same source binary. A first translation binary includes compiler optimizations not present in a second translation binary. During runtime, a dispatcher directs control flow of a CPU when branch instructions are reached. Specifically, a dispatcher directs a CPU to execute instructions in the first translation binary, and accesses the second translation binary when an instruction is to a target that is not addressable in the first translation binary. The first and second translation binaries enable a target processing architecture to emulate a source processing architecture without just-in-time compilation or other runtime interpretation.

Abstract: Device for harvesting direct sunlight, transmitting diffuse sunlight and for scattering light from a light source to provide illumination, including: a receiving layer including at least one solar energy collector and at least one light source; at least one optical component disposed on a first side of the receiving layer, the optical component including at least one plano-convex refracting element; a second optical component disposed on a second side of the receiving layer, the second optical component comprising at least one optical element; wherein the at least one plano-convex element is positioned to receive direct light and refract it towards the at least one optical element of the second optical component, and wherein the optical element is positioned to reflect light towards the solar energy collector; wherein the at least one optical element is positioned to refract and emit indirect light impinging thereon towards the exterior of the apparatus.

Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.

Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

Abstract: A method for patterning a layer increases the density of features formed over an initial patterning layer using a series of self-aligned spacers. A layer to be etched is provided, then an initial sacrificial patterning layer, for example formed using optical lithography, is formed over the layer to be etched. Depending on the embodiment, the patterning layer may be trimmed, then a series of spacer layers formed and etched. The number of spacer layers and their target dimensions depends on the desired increase in feature density. An in-process semiconductor device and electronic system is also described.

Abstract: A method for patterning a layer increases the density of features formed over an initial patterning layer using a series of self-aligned spacers. A layer to be etched is provided, then an initial sacrificial patterning layer, for example formed using optical lithography, is formed over the layer to be etched. Depending on the embodiment, the patterning layer may be trimmed, then a series of spacer layers formed and etched. The number of spacer layers and their target dimensions depends on the desired increase in feature density. An in-process semiconductor device and electronic system is also described.

Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

Abstract: Novel tetrahydroisoquinoline derivative compounds are disclosed herein that may be used as an active ingredient for a pharmaceutical composition, and in particular, for a pharmaceutical composition useful for preventing or treating a disease or condition responsive to modulation of the contractility of the skeletal sarcomere. This may be accomplished, for example, by modulation of the troponin complex of the fast skeletal muscle sarcomere through one or more of fast skeletal myosin, actin, tropomyosin, troponin C, troponin I, and troponin T, and fragments and isoforms thereof. The tetrahydroisoquinoline derivative compounds can thus be used as an agent for preventing or treating 1) neuromuscular disorders, 2) disorders of voluntary muscle, 3) CNS disorders in which muscle weakness, atrophy, and fatigue are prominent symptoms, 4) muscle symptoms stemming from systemic disorders, and 5) dysfunctions of pelvic floor and urethral/anal sphincter muscle.

Abstract: Device for concentrating and harvesting sunlight comprising: A panel having rigid layer having a patterned electrical circuit thereon. An array of sunlight concentrating and harvesting units, each unit being formed by at least one rigid element and a portion of the rigid layer; and including: a rigid optical concentrating element, a photovoltaic cell sandwiched within the panel for converting sunlight into electrical energy, and an electrical conductor. The electrical conductor being the primary heat sink for the photovoltaic cell, the photovoltaic cell being primarily cooled via conduction. The electrical conductor and the optical concentrating element being dimensioned and arranged within the unit such that the electrical conductor does not materially impede transmission of sunlight to the photovoltaic cell. The electrical conductor transmitting electrical and thermal energy received from the photovoltaic cell away from the unit.

Abstract: A frame for mounting a plurality of solar tracking units is provided. The frame comprises a plurality of leg assemblies interconnected by trusses to provide a stable structure that is ballasted by the frame's own weight, rather than relying on external ballast such as concrete blocks. Each leg assembly is provided with a shaft with a mounting end for mounting a solar tracking unit. Each solar tracking unit includes an armature assembly and at least one motor for controlling the orientation and position of a solar panel mounted thereon. Solar tracking assemblies, each comprising the frame and plurality of solar tracking units, can be assembled in an array using connectors spacing the assemblies, thus providing enhanced stability. Each of the assemblies can be provided with a local control unit for controlling each individual solar tracking unit, and a global control unit may be used to control the local control units.

Abstract: Novel tetrahydroisoquinoline derivative compounds are disclosed herein that may be used as an active ingredient for a pharmaceutical composition, and in particular, for a pharmaceutical composition useful for preventing or treating a disease or condition responsive to modulation of the contractility of the skeletal sarcomere. This may be accomplished, for example, by modulation of the troponin complex of the fast skeletal muscle sarcomere through one or more of fast skeletal myosin, actin, tropomyosin, troponin C, troponin I, and troponin T, and fragments and isoforms thereof. The tetrahydroisoquinoline derivative compounds can thus be used as an agent for preventing or treating 1) neuromuscular disorders, 2) disorders of voluntary muscle, 3) CNS disorders in which muscle weakness, atrophy, and fatigue are prominent symptoms, 4) muscle symptoms stemming from systemic disorders, and 5) dysfunctions of pelvic floor and urethral/anal sphincter muscle.

Abstract: A method for patterning a layer increases the density of features formed over an initial patterning layer using a series of self-aligned spacers. A layer to be etched is provided, then an initial sacrificial patterning layer, for example formed using optical lithography, is formed over the layer to be etched. Depending on the embodiment, the patterning layer may be trimmed, then a series of spacer layers formed and etched. The number of spacer layers and their target dimensions depends on the desired increase in feature density. An in-process semiconductor device and electronic system is also described.

Abstract: A cationic-stabilized dispersion for use in fabricating an in-mold coated article including at least one of a cationic-stabilized polyurethane dispersion, a cationic-stabilized acrylic dispersion, a cationic-stabilized polyacrylamide dispersion, a cationic-stabilized polyallylamine dispersion, a cationic-stabilized polyetheramine dispersion, and a cationic-stabilized chitosan dispersion.

Abstract: The present invention provides a table arrangement 100 for use in an aircraft seat module, the table arrangement comprising a first table element suitable for being movably mounted to a mounting structure of the aircraft seat module, the first table element being provided with a first table surface, a second table element provided with a second table surface substantially parallel to the first table surface, wherein the second table element is mounted to the first table element, such that the second table element is moveable from a first position with respect to the first table element to a second position with respect to the first table element, the second position being transformed from the first position within the plane of the second table element. The present invention also provides an aircraft seat module, an aircraft and a method of deploying a table arrangement.

Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

Abstract: A method for patterning a layer increases the density of features formed over an initial patterning layer using a series of self-aligned spacers. A layer to be etched is provided, then an initial sacrificial patterning layer, for example formed using optical lithography, is formed over the layer to be etched. Depending on the embodiment, the patterning layer may be trimmed, then a series of spacer layers formed and etched. The number of spacer layers and their target dimensions depends on the desired increase in feature density. An in-process semiconductor device and electronic system is also described.

Abstract: A cationic-stabilized dispersion for use in fabricating an in-mold coated article including at least one of a cationic-stabilized polyurethane dispersion, a cationic-stabilized acrylic dispersion, a cationic-stabilized polyacrylamide dispersion, a cationic-stabilized polyallylamine dispersion, a cationic-stabilized polyetheramine dispersion, and a cationic-stabilized chitosan dispersion.