Abstract: The invention is a method of identifying the presence of, and monitoring, a disease state in a mammal which is associated with degradation of connective tissue in the mammal. The method detects and determines whether diagnostically or prognostically significant levels of YKL-40 protein and/or YKL-40 peptide are present in a biological sample. The method can be used, for example, to identify the presence of inflammatory joint disease or degeneration of connective tissue in organs. Serum YKL-40 levels as detected and quantified by the invention method are also suggestive of the prognosis for the length of survival in breast cancer patients following recurrence and/or metastasis of their cancers.

Abstract: The present invention provides serum-free cell culture media formulations which are capable of supporting the in vitro cultivation of animal cells. The media comprise at least one nutrient of non-animal derivation, such as at least one plant peptide and/or at least one non-animal or plant lipid and/or fatty acid. The media may further optionally comprise an enzymatic digest or extract of yeast cells. The present invention also provides methods of cultivating animal cells in vitro using these cell culture media formulations. In addition, the media of the present invention can be used for growth of animal cells for virus production.

Abstract: A sign-off method for use in verifying of embedded test structures in a circuit design extracts a description of all embedded test structures from a circuit description to create a test connection map file, and verifies the connections of the test structures to circuit pins or nets, creates verification configuration files for use, in performing a sign-off verification of the circuit, for a circuit containing logic test structures, verifies that each logic test structure complies with logic test design rules and creates logic test vectors and a reference signature, performs a formal verification and a static timing analysis of the circuit, generates a sign-off simulation test bench for each test structure using the verification configuration files and the test connection map file, executes the test benches to simulate all test structures in the circuit; and creates manufacturing test patterns.

Abstract: A system and method of calibrating a vehicle odometer (12) includes a controller (18) receiving signals from the odometer (12) indicative of movement of the vehicle (10) and a receiver (26) indicative of distance traveled. The controller (18) obtains information indicative of movement of the vehicle (10) in response to travel at a constant speed. The receiver (26) provides signals indicative of the distance traveled to the controller (18). The controller (18) determines an average number of signals relative to distance and compares the average number to a current number of signals relative to distance. Odometer calibration updates if the average and current number of signals relative to distance differs by a predetermined amount. The number of signals relative to the distance is only recorded when the vehicle (10) is traveling at a constant speed, eliminating aberrant data from odometer calibration.

Abstract: An embedded test, chip design utility is an ease-of-use utility for assisting a circuit designer in quickly implementing a circuit embedded test design flow. Using the utility, a designer transforms a design netlist to include embedded test structures. The utility automatically builds a workspace containing a predetermined repository structure and design environment, generates control files for executing design automation tools that operate within the design flow, and encapsulates the data so as to be self-contained and easily transferable to other design teams.

Abstract: A program product for use in generating test benches for verifying test structures embedded in a circuit, comprises a verification specification processor for parsing a verification specification containing test specifications for selected test structures and a test bench generator for each of one or more types of embedded test structures, each test bench generator being operable to process a test structure specification of a test structure of a corresponding test structure type and generate a test bench using data contained in said test specifications of said verification specification, data contained in said test structure specification and data contained in a test connection specification.

Abstract: A sign-off method for use in verifying of embedded test structures in a circuit design extracts a description of all embedded test structures from a circuit description to create a test connection map file, and verifies the connections of the test structures to circuit pins or nets, creates verification configuration files for use, in performing a sign-off verification of the circuit, for a circuit containing logic test structures, verifies that each logic test structure complies with logic test design rules and creates logic test vectors and a reference signature, performs a formal verification and a static timing analysis of the circuit, generates a sign-off simulation test bench for each test structure using the verification configuration files and the test connection map file, executes the test benches to simulate all test structures in the circuit; and creates manufacturing test patterns.

Abstract: An embedded test, chip design utility is an ease-of-use utility for assisting a circuit designer in quickly implementing a circuit embedded test design flow. Using the utility, a designer transforms a design netlist to include embedded test structures. The utility automatically builds a workspace containing a predetermined repository structure and design environment, generates control files for executing design automation tools that operate within the design flow, and encapsulates the data so as to be self-contained and easily transferable to other design teams.

Abstract: This invention is a method of identifying the presence of, and monitoring, a disease state in a mammal which is associated with degradation of connective tissue in the mammal. The method detects and determines whether diagnostically or prognostically significant levels of YKL-40 protein and/or YKL-40 peptide are present in a biological sample. The method can be used, for example, to identify the presence of inflammatory or degenerative joint disease or degeneration of connective tissue in organs. Serum YKL-40 levels as detected and quantified by the inventive method are also suggestive of the prognosis for the length of survival in breast cancer patients following recurrence and/or metastasis of their cancers. The figure shows the elution position of substantially pure serum YKL-40 on a gel filtration column.

Abstract: A latch device for a manual tong apparatus that incorporates a secondary catch mechanism is presented. Such a secondary catch would assist in maintaining the tong assembly in it's closed position during a reversing operation or at a time when load applied to the manual tong device in the gripping direction is very low. Additionally the secondary catch would also provide some additional protection by holding the tong assembly together in the event of a failure of certain tong components. The mechanism of the secondary catch is spring loaded and operates through two secondary up-down catch arms that are deactivated by swinging a handle in the direction that corresponds to the operator's natural motion to open the lug jaw.

Abstract: This invention provides methods of inhibiting calcification of a soft tissue (e.g., an artery, a heart valve, an atherosclerotic plaque, a cancer, a kidney, a prostate, skin, muscle, cartilage, viscera, and heart muscle) in a mammal. These methods involve inhibiting osteoclastic bone resorption in said mammal (e.g., a mammal diagnosed as having or at risk for a pathology characterized by calcification of a soft tissue). The inhibition is preferably by administration of a bisphosphonate to the mammal in a concentration sufficient to inhibit bone resorption without inhibiting bone mineralization. The methods of this invention can also be used to mitigate a symptom of atherosclerosis in a mammal. Such methods involve inhibiting osteoclastic bone resorption in the mammal.

Abstract: A system and method of calibrating a vehicle odometer (12) includes a controller (18) receiving signals from the odometer (12) indicative of movement of the vehicle (10) and a receiver (26) indicative of distance traveled. The controller (18) obtains information indicative of movement of the vehicle (10) in response to travel at a constant speed. The receiver (26) provides signals indicative of the distance traveled to the controller (18). The controller (18) determines an average number of signals relative to distance and compares the average number to a current number of signals relative to distance. Odometer calibration updates if the average and current number of signals relative to distance differs by a predetermined amount. The number of signals relative to the distance is only recorded when the vehicle (10) is traveling at a constant speed, eliminating aberrant data from odometer calibration. (FIG.

Abstract: This invention is a method of identifying the presence of, and monitoring, a disease state in a mammal which is associated with degradation of connective tissue in the mammal. The method detects and determines whether diagnostically or prognostically significant levels of YKL-40 protein and/or YKL-40 peptide are present in a biological sample. The method can be used, for example, to identify the presence of inflammatory or degenerative joint disease or degeneration of connective tissue in organs. Serum YKL-40 levels as detected and quantified by the inventive method are also suggestive of the prognosis for the length of survival in breast cancer patients following recurrence and/or metastasis of their cancers. The figure shows the elution position of substantially pure serum YKL-40 on a gel filtration column.

Abstract: A latch device for a manual tong apparatus that incorporates a secondary catch mechanism is presented. Such a secondary catch would assist in maintaining the tong assembly in it's closed position during a reversing operation or at a time when load applied to the manual tong device in the gripping direction is very low. Additionally the secondary catch would also provide some additional protection by holding the tong assembly together in the event of a failure of certain tong components. The mechanism of the secondary catch is spring loaded and operates through two secondary up-down catch arms that are deactivated by swinging a handle in the direction that corresponds to the operator's natural motion to open the lug jaw.

Abstract: The invention is a method of identifying the presence of, and monitoring, a disease state in a mammal which is associated with degradation of connective tissue in the mammal. The method detects and determines whether diagnostically or prognostically significant levels of YKL-40 protein and/or YKL-40 peptide are present in a biological sample. The method can be used, for example, to identify the presence of inflammatory joint disease or degeneration of connective tissue in organs. Serum YKL-40 levels as detected and quantified by the invention method are also suggestive of the prognosis for the length of survival in breast cancer patients following recurrence and/or metastasis of their cancers.

Abstract: A multi-part handle system that incorporates bumper flanges disposed at opposite ends of a rigid handle device is proposed. The handle mounts to a manual tong apparatus, or any other piece of heavy equipment, by means of weldable or integrally cast brackets and provides a rigid but shock absorbing grip for the operator's hand. In the event that the bumper flanges become damaged or are torn off the handle assembly the rigid handle device will continue to provide a safe manipulation means while replacement bumpers are located. In contrast to prior art safety handles, rig operators will be able to deploy safety handles without the fear of lost rig time if the bumper components become damaged. A soft ergonomic grip cover is incorporated into the preferred embodiment of the safety to make gripping the handle assembly more comfortable and tactile for the operator.

Abstract: The invention is a method of identifying the presence of, and monitoring, a disease state in a mammal which is associated with degradation of connective tissue in the mammal. The method detects and determines whether diagnostically or prognostically significant levels of YKL-40 protein and/or YKL-40 peptide are present in a biological sample. The method can be used, for example, to identify the presence of inflammatory or degenerative joint disease or degeneration of connective tissue in organs. Serum YKL-40 levels as detected and quantified by the inventive method are also suggestive of the prognosis for the length of survival in breast cancer patients following recurrence and/or metastasis of their cancers. The figure shows the elution position of substantially pure serum YKL-40 on a gel filtration column.

Abstract: Improved fluid loss control in gravel pack placement fluids is achieved when a fluid loss control additive is provided comprising a selectively soluble particulate having a size of less than 1000 microns and having a linear size distribution when cumulative weight percent is plotted against the logarithm of the particle size. The preferred selectively soluble particulate comprises calcium carbonate.

Abstract: Immunoassay and compositions therefore for detection of human vitamin K-dependent bone protein. Heterologous labeled vitamin K-dependent protein or antigenic fragment thereof is employed with antibodies to the protein in an assay for the protein in various physiological fluids for bone extracts. The assay may be used in the diagnosis of bone diseases, by itself or in conjunction with an alkaline phosphatase assay.

Abstract: For the purposes of severing and separating a plurality of cup-shaped object supports (2) of plastic material, which are interconnectedly arranged on a support plate (1), use is made of a method wherein the support plate (1) is first put into a gripping device (4) and secured therein. Subsequently a severing device (5) which is displaceable in the plane of the support plate (1) is set in motion to sever the cup-shaped object supports by means of a saw blade (14). The object supports (2) fall into the respectively associated glass reagent vessels (20) by way of distributor passages (18) which lead downwardly in a truncated pyramid configuration, which reagent vessels can be pushed into position below the distributor block (17) in a container carrier (19). The method according to the invention replaces the conventional operations of severing and separating the object supports (2) by a shears.