Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.

Abstract: A key manager provides a way to separate out the management of encryption keys and policies from application domains. The key manager may create cipher objects that may be used by the domains to perform encryption or decryption, without exposing the keys or encryption/decryption algorithms to the domains. A master key managed by the key manager may be used to encrypt and decrypt the domain keys that are stored under the control of the key manager. The key manager supports the rekeying of both the master key and the domain keys based on policy. Multiple versions of domain keys may be supported, allowing domains to access data encrypted with a previous version of a domain key after a rekeying.

Abstract: Systems and methods for stateless system management are described. Examples include a method wherein a user sends the management system a request to act upon a managed system. The management system determines whether the user is authorized for the requested action. Upon authorization, the management system looks up an automation principal, which is a security principal native to the managed system. The management system retrieves connecting credentials for the automation principal, and connects to the managed system using the retrieved credentials. Once the managed system is connected, the management system performs the requested action on the managed system, and sends the result back to the user.

Abstract: A key manager provides a way to separate out the management of encryption keys and policies from application domains. The key manager may create cipher objects that may be used by the domains to perform encryption or decryption, without exposing the keys or encryption/decryption algorithms to the domains. A master key managed by the key manager may be used to encrypt and decrypt the domain keys that are stored under the control of the key manager. The key manager supports the rekeying of both the master key and the domain keys based on policy. Multiple versions of domain keys may be supported, allowing domains to access data encrypted with a previous version of a domain key after a rekeying.

Abstract: A key manager provides a way to separate out the management of encryption keys and policies from application domains. The key manager may create cipher objects that may be used by the domains to perform encryption or decryption, without exposing the keys or encryption/decryption algorithms to the domains. A master key managed by the key manager may be used to encrypt and decrypt the domain keys that are stored under the control of the key manager. The key manager supports the rekeying of both the master key and the domain keys based on policy. Multiple versions of domain keys may be supported, allowing domains to access data encrypted with a previous version of a domain key after a rekeying.

Abstract: Systems and methods for stateless system management are described. Examples include a method wherein a user sends the management system a request to act upon a managed system. The management system determines whether the user is authorized for the requested action. Upon authorization, the management system looks up an automation principal, which is a security principal native to the managed system. The management system retrieves connecting credentials for the automation principal, and connects to the managed system using the retrieved credentials. Once the managed system is connected, the management system performs the requested action on the managed system, and sends the result back to the user.

Abstract: Systems and methods for stateless system management are described. Examples include a method wherein a user sends the management system a request to act upon a managed system. The management system determines whether the user is authorized for the requested action. Upon authorization, the management system looks up an automation principal, which is a security principal native to the managed system. The management system retrieves connecting credentials for the automation principal, and connects to the managed system using the retrieved credentials. Once the managed system is connected, the management system performs the requested action on the managed system, and sends the result back to the user.

Abstract: Systems and methods for stateless system management are described. Examples include a method wherein a user sends the management system a request to act upon a managed system. The management system determines whether the user is authorized for the requested action. Upon authorization, the management system looks up an automation principal, which is a security principal native to the managed system. The management system retrieves connecting credentials for the automation principal, and connects to the managed system using the retrieved credentials. Once the managed system is connected, the management system performs the requested action on the managed system, and sends the result back to the user.

Abstract: A key manager provides a way to separate out the management of encryption keys and policies from application domains. The key manager may create cipher objects that may be used by the domains to perform encryption or decryption, without exposing the keys or encryption/decryption algorithms to the domains. A master key managed by the key manager may be used to encrypt and decrypt the domain keys that are stored under the control of the key manager. The key manager supports the rekeying of both the master key and the domain keys based on policy. Multiple versions of domain keys may be supported, allowing domains to access data encrypted with a previous version of a domain key after a rekeying.

Abstract: The present invention relates to novel pharmaceutical compositions comprising at least one direct thrombin inhibitor and at least one additional active compound selected from the groups consisting of platelet inhibitors, low molecular weight heparins (LMWH) and heparinoids as well as unfractionated heparin, factor Xa inhibitors, combined thrombin/factor Xa inhibitors, fibrinogen receptor antagonists (glycolprotein IIb/IIa antagonists) and Vitamin K antagonists, optionally together with one or more pharmaceutically acceptable excipients or carriers for the treatment of thrombosis.

Abstract: The invention relates to new indications for direct thrombin inhibitors such as dabigatran etexilate in the CNS and other fields.

Abstract: Techniques and systems are disclosed for storing instances of an opaque type in a database according to a direct path loading approach. According to one aspect, an opaque type implementor registers, with a loader application, routines that the opaque type implementor implements. In response, the loader application associates the opaque type with the routines. The loader application reads data that comprises instances of the opaque type. The loader application determines which routines are associated with the opaque type. The loader application invokes the routines, which create an array for storing instances of the opaque type and populate the array with values specified in the data. The loader application converts the array into a data stream that conforms to the format of the database's data blocks. The loader application then streams the data to a database server, which writes the data directly into data blocks in the database.

Abstract: The invention relates to new indications for direct thrombin inhibitors such as dabigatran etexilate in the CNS and other fields.

Abstract: The invention relates to new indications for direct thrombin inhibitors such as dabigatran etexilate in the cardiovascular field.

Abstract: A centralized queue for a network printing system is provided for allowing clients of a network printer to make job requests and enter a spot in a job queue without transmitting the actual print job data to the network. More particularly, an imaging device protocol (IDP) is provided which operates independently of the network layers below and only requires that a transport protocol/port be bidirectional. A wide variety of heterogenous network protocols may be supported by IDP for placing all of the incoming print job information in a print queue regardless of the protocol. Print job information from both IDP and non-IDP protocol/ports may be placed in the print queue by emulating IDP on the non-IDP protocol/ports. As a result, job information for all of the print jobs attempting to access a busy printer may be stored in the print queue so that the print jobs can be printed by the printer with a fair arbitration once the network printer becomes available.

Abstract: The present invention relates to novel pharmaceutical compositions comprising at least one direct thrombin inhibitor and at least one additional active compound selected from the groups consisting of platelet inhibitors, low molecular weight heparins (LMWH) and heparinoids as well as unfractionated heparin, factor Xa inhibitors, combined thrombin/factor Xa inhibitors, fibrinogen receptor antagonists (glycolprotein IIb/IIa antagonists) and Vitamin K antagonists, optionally together with one or more pharmaceutically acceptable excipients or carriers for the treatment of thrombosis.

Abstract: The invention provides a method of providing content to a mobile terminal, the method comprising the steps of: receiving data at the mobile terminal; classifying the content data in accordance with classification data comprised within the content data; storing the content data within the mobile terminal; creating an access object whereby the content data may be accessed; and associating the access object with further access objects having similar classification codes. This method has a significant effect in simplifying the provision of content to mobile terminals.