Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.

Abstract: Catalyst compositions and methods of preparation comprising: preparing a promoter metal-molecular sieve catalyst composition comprising a promoter metal and a molecular sieve; and incorporating an iron salt into the promoter metal-molecular sieve catalyst composition.

Abstract: An electronic system for a drug delivery device is provided. The electronic system comprises a dose setting and drive mechanism comprising a first member and a second member, wherein in the dose delivery operation and/or in the dose setting operation, the first member moves, e.g. rotates, relative to the second member; an electronic control unit; an electrical use detection unit operatively connected to the electronic control unit, and configured to generate a use signal in response to the relative movement, e.g. a relative rotational movement, between the first member and the second member, preferably during the dose delivery operation. The electronic system is configured such that it is switched from a first state into a second state by the electronic control unit in response to the use signal, wherein the electronic system has an increased electrical power consumption in the second state as compared to the first state.

Abstract: A system and method enabling the automated installation and configuration of satellite system premises device. The system and method provide for tuning, locking and recognizing particular types of satellite system signals, and then responsively configuring and installing a premises device. The disclosed technology is capable of adapting to both one and two cable satellite premises systems, and is compatible with wideband low-noise block signals, as well as universal low-noise block and single-cable second-generation satellite signals.

Abstract: A low pressure gear pump and wear plate is disclosed. The wear plate may comprise a sidewall, a drive portion, a driven portion, and a transition portion. The sidewall is free of a sealing member or a recess configured to receive the sealing member. The drive portion includes a drive inlet lip, a drive outlet lip, a drive recessed trough and a drive bore. The drive bore is configured to receive the drive shaft of the gear pump. The driven portion may that include a driven inlet lip, a driven outlet lip, a driven recessed trough, and a driven bore. The driven bore is configured to receive the driven shaft of the gear pump. The transition portion may include a transition aperture configured to receive a first fastener configured to mount the wear plate to the gear housing. The wear plate is made of bronze, aluminum or non-magnetic material.

Abstract: Methods of characterizing an analyte using a nanopore. One aspect features methods for characterizing a double-stranded polynucleotide using a nanopore, e.g., without using a hairpin connecting a template and a complement of the double-stranded polynucleotide. Another aspect features methods for characterizing an analyte using a tag-modified nanopore with increased sensitivity and/or higher throughput. Compositions and systems including, e.g., adaptors for attachment to double-stranded polynucleotides and tag-modified nanopores, which can be used in the methods are also provided.

Abstract: An acid-generating fluid includes a thermally activated strong acid precursor. The thermally activated strong acid precursor can include a component selected from aldehydes, ketones, and combinations thereof, in combination with a precursor of a compound adapted to react to liberate sulfur dioxide; or it can include sulfur dioxide in combination with a precursor of a compound adapted to react to liberate a component selected from aldehydes, ketones, and combinations thereof.

Abstract: Provided herein is a method of concentrating a tethering complex in a region of an amphiphilic layer, such as a lipid membrane. Also provided herein are methods of assembling a tethering complex; methods of concentrating an analyte in the region of a detector; amphiphilic layers; and arrays and devices for use in the disclosed methods.

Abstract: Described are receptor ligands of transient receptor potential cation channel subfamily V member 4 (TRPV4), pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating ocular disorders.

Abstract: Bias circuit elements for applying voltages/currents to a photodetector are described. Bias circuit elements described are active devices, e.g. mosfets, directly connected to the photodetector signal point, which inject noise that will be amplified/integrated. Lowering 1/f noise in these bias devices uses multiple parallel mosfets and switching the parallel mosfets gates between a bias activation level signal and a voltage sufficient to drive the mosfet into accumulation Gate switching may be accomplished by at least two partially out of phase clocking signals, with at least one parallel mosfet applying bias while another is in accumulation in continuously switched time periods. Gate switching at a frequency higher than the imaging bandwidth, will have negligible effect on the image signal. During the accumulation phase traps present within the conducting channel of each MOSFET will be depopulated, essentially resetting the MOSFET's 1/f noise, allowing for long integration times while controlling 1/f noise.

Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.

Abstract: One or more embodiments described herein disclose methods and systems that are directed at providing enhanced privacy, efficiency and security to distributed ledger-based networks (DLNs) via the implementation of zero-knowledge proofs (ZKPs) in the DLNs. ZKPs allow participants of DLNs to make statements on the DLNs about some private information and to prove the truth of the information without having to necessarily reveal the private information publicly. As such, the disclosed methods and systems directed at the ZKP-enabled DLNs provide privacy and efficiency to participants of the DLNs while still allowing the DLNs to remain as consensus-based networks.

Abstract: A method of generating a custom template includes importing user account data including a plurality of user-defined account identifiers, receiving a user input on a graphical user interface including a mapping of the plurality of user-defined account identifiers to predetermined categories and a selected ordering of two or more of the user-defined account identifiers that are mapped to the same one of the predetermined categories, for each of the user-defined account identifiers, generating a code defining the predetermined category to which the user-defined account identifier is mapped and an order ranking of the user-defined account identifier relative to any others of the user-defined account identifiers that are mapped to the same predetermined category, and generating one or more templates comprising a representation of at least a portion of the user account data organized according to the predetermined categories and order rankings defined by one or more of the codes.

Abstract: A drug delivery device comprising: a housing; a cylindrical member rotatably supported within the housing; and a plurality of sensors; wherein: the outer surface of the cylindrical member is provided with a single track, the track forming an encoder and having a plurality of first track segments and a plurality of second track segments arranged along the length of the track which are respectively capable of inducing first and second responses in the sensors; and in each rotational position of the cylindrical member relative to the housing at least one different first track segment is capable of inducing a first response in at least one said sensor, thereby enabling the rotational position of the cylindrical member relative to the housing to be determined.

Abstract: A passive NOx absorber for treating an exhaust gas from a diesel engine is described. The passive NOx absorber comprises a first washcoat region comprising a zeolite catalyst, the zeolite catalyst comprising a noble metal and a zeolite having a SAR of 2-15.

Abstract: A method of pollinating a plant: flying an unmanned aerial vehicle above the plant and generating a thrust that contacts the plant, that produces a sound pressure level of at least 6×10?5 Pascal at the plant, and that produces a frequency that induces the plant to release pollen.

Abstract: A booster explosive (10) comprises a canister body 12 within which is a cap well (20) having disposed therein a detonator (24). A protective sleeve (28) encloses the cap well (20) except for that portion of the cap well, the active portion (20d), which encloses the explosive end section (24a) of detonator (24). The protective sleeve serves to attenuate the force of shock waves from nearby prior explosions acting on the detonator (24). An annular air space (32) may be provided between protective sleeve (28) and cap well (20) to further attenuate the force of such shock waves. Attenuation of the shock waves reduces the likelihood of damage to detonators (24) by prior nearby explosions.

Abstract: A method of making an optical fiber-based sensor includes providing an optical fiber, and providing a sensing or protection layer on a surface of the optical fiber by an atomic layer deposition (ALD) process.

Abstract: Methods of characterizing an analyte using a nanopore. One aspect features methods for characterizing a double-stranded polynucleotide using a nanopore, e.g., without using a hairpin connecting a template and a complement of the double-stranded polynucleotide. Another aspect features methods for characterizing an analyte using a tag-modified nanopore with increased sensitivity and/or higher throughput. Compositions and systems including, e.g., adaptors for attachment to double-stranded polynucleotides and tag-modified nanopores, which can be used in the methods are also provided.

Abstract: A rotary pneumatic seal may have a ring-shaped inner radial seal with an inner lip extending in an axial direction, an outer lip extending in the same axial direction, a connecting flange connecting the inner lip and the outer lip, a pneumatic sealing lip, and an oil sealing lip. The rotary pneumatic seal may also have a ring-shaped outer radial seal located radially outward from the inner radial seal. The outer radial seal may also have a first wall extending in an outward radial direction, a second wall extending in an opposite inward radial direction, a central flange connecting the first and second walls, and a dust lip.