Abstract: An example method comprising requesting authorization to reprocess a replaceable supply component using first data stored in memory of the replaceable supply component and an interface, the first data including original manufacturing data for the replaceable supply component. The method further comprises, in response to the request, receiving second data using the interface, and appending the original manufacturing data stored in the memory with the second data to designate the replaceable supply component as reprocessed.

Abstract: Entity aggregation for security computing resources involves an aggregation covenant that conditionally conveys rights to aggregation members. The ruling covenant is defined for protecting one or more computing resources by overriding system-level and/or entity-specific rights (e.g., super-users). An aggregation configuration module defines an aggregation-specific instance of an entity (user/device, process, or data) that receives the conveyed rights. The entity can use the rights conveyed only through its corresponding instance.

Abstract: CD37-specific bispecific antibody molecules binding to different epitopes of the human CD37 antigen which bispecific antibody molecules have enhanced Fc-Fc interactions upon binding to CD37 on the cell surface. The invention also relates to the monoclonal parental antibodies from which the first or the second binding region of the bispecific antibody molecules is obtained. The invention also relates to pharmaceutical compositions containing these molecules and the treatment of cancer and other diseases using these compositions.

Abstract: The disclosure provides gene therapy vectors, such as adeno-associated virus (AAV), designed for treatment of Lysosomal Acid Lipase Deficiency (LAL-D) disorders such as Wolman Disease and cholesterol ester storage disease (CESD). The disclosed rAAV provide a wild type lipase A (LIRA) cDNA to a subject in need which results in expression of the wild type protein.

Abstract: An example method includes connecting a flow cell to an instrument. The flow cell includes a flow channel including a manifold section having a manifold section swept volume and a detection section having a detection section swept volume. A ratio of the detection section swept volume to manifold section swept volume is at least 10 to 1. A first reagent is pumped through the flow channel. A first chemical reaction is performed between the first reagent and analytes positioned in the detection section. A subsequent reagent is pumped through the flow channel to flush out the remaining reagent. A concentration of at least 99.95 percent of reagent positioned in the detection section is the subsequent reagent, after pumping a total volume of the subsequent reagent through the flow channel that is equal to or less than 2.5 times a total swept volume of the manifold section plus the detection section.

Abstract: Medical devices and methods of using medical devices are disclosed. An example tissue retraction device includes a first engagement member having a first end and a second end, a second engagement member having a first end and a second end, a first elastic member attached to the second end of the first engagement member, and a first alignment member having a first end, a second end and a lumen extending therethrough. Further, the tissue retraction device has a first length, the first alignment member has a second length, the first elastic member extends within the lumen of the first alignment member and the second length of the first alignment member is less than or equal to the first length of the tissue retraction device.

Abstract: Described herein is a golf club head that comprises a body and a strike plate. The body comprises a heel portion, a sole portion, a toe portion, and a top portion. The strike plate comprises an outer peripheral edge and at least a portion of a strike face. Furthermore, the strike plate is welded to the body via a peripheral weld between the outer peripheral edge of the strike plate and the body. The outer peripheral edge of the strike plate comprises at least one welded portion, welded to the body via the peripheral weld, and at least one non-welded portion, not welded to the body.

Abstract: Measures for managing satellite bearer resources of a satellite telecommunications network. A corpus of data based on historical satellite bearer resource allocations is maintained. A machine learning agent is trained with the corpus to determine a plurality of weights for use in directing satellite bearer resource management in the satellite telecommunications network. A satellite bearer resource allocation request is received. A set of features is extracted from a current environment of the satellite telecommunications network. The set of features defines currently allocated satellite bearer resources. On the basis of the determined plurality of weights and the set of features, satellite bearer resources of the satellite telecommunications network are managed to satisfy the request.

Abstract: A polymer electrolyte is disclosed that includes a polymer backbone containing a high dipole moiety and a low Tg moiety and a salt combined with the polymer. In addition to other possible benefits, the high dipole moiety in the polymer backbone may improve the conductivity of the polymer electrolyte. Additionally, the combination of a moiety with a high dipole moment with a moiety to impart low Tg may result in a high dielectric constant (for example, greater than 10).

Abstract: Systems and methods configured for receiving, from a user device associated with a user, a first request to associate the user with a target and account information associated with the user; retrieving the target from a database to associate the user with the retrieved target; receiving, from an entity, event data associated with the account information; computing an amount of contribution based on the received event data; transmitting the computed amount of contribution to a distribution system configured to distribute the contribution to the associated target; updating the database by aggregating the computed amount of contribution to a stored contribution data associated with the user; retrieving pre-authenticated data of the user allowing transmission of a message to a public forum; generating the message based on the event data and the computed amount of contribution; and transmitting the message to one or more devices via the public forum.

Abstract: CD37-specific bispecific antibody molecules binding to different epitopes of the human CD37 antigen which bispecific antibody molecules have enhanced Fc-Fc interactions upon binding to CD37 on the cell surface. The invention also relates to the monoclonal parental antibodies from which the first or the second binding region of the bispecific antibody molecules is obtained. The invention also relates to pharmaceutical compositions containing these molecules and the treatment of cancer and other diseases using these compositions.

Abstract: Acoustic waveguides can be used to improve audio performance of playback devices, such as a soundbar. Such a playback device can include an elongated body defining an outer perimeter with a forward surface, an upper surface, and a rounded edge between the forward surface and the upper surface. An up-firing transducer is configured to direct sound along an axis that has a vertical oblique angle with respect to a forward axis. A waveguide in fluid communication with the up-firing transducer includes a sidewall extending circumferentially around the transducer, the sidewall having a first end adjacent the up-firing transducer and a second end adjacent the outer perimeter, such that an opening defined by the sidewall has a larger area at the second end than at the first end. A rear portion of the sidewall is more steeply angled with respect to the axis than a forward portion of the sidewall.

Abstract: A method for moderation in a permissioned blockchain using a hash-oriented scheme includes: storing a blockchain including a most recent block; receiving transaction data values; receiving a first reference value and a second reference value; generating a first hash value by hashing the first reference value; generating a block proof including the first hash value, a second hash value, a third reference value, and a block value; verifying a block header of the most recent block using the block proof; receiving a new block value; generating a new block header including the first reference value, the second reference value, a fourth reference value, and the new block value; generating a new block for the blockchain including the new block header and the transaction data values; and transmitting the new block to one or more additional nodes associated with the blockchain.

Abstract: A computer-implemented method, computer program product, and computer system for accessing content on a web page. The method accesses a displayed web page in a web browser of a user computing device and receives a search term for content within the web page. The method accesses contextual information held locally on the user computing device and scans the web page to identify one or more portions of content of the web page relevant to the search term and the contextual information. The method provides a display on the user computing device with links to the relevant web page content.

Abstract: The present disclosure provides a vehicle fluid delivery system comprising (a) a housing defining a first cavity, wherein the housing includes a first side and a second side opposite the first side, the first side and the second side being separated by a continuous side wall extending around their peripheries, and wherein the housing is adapted to be removable from a vehicle, (b) a fluid reservoir positioned in the first cavity of the housing, (c) a fluid port coupling disposed on the first side of the housing and providing fluid access to the fluid reservoir, and (d) a fluid barrier external to and contiguous with the side wall.

Abstract: A method, system, and computer program product for performing microservice-aware reference policy checking that accept stateful security policies. The method may include receiving a stateful security policy, where the stateful security policy has connection to previous data. The method may also include determining that the stateful security policy applies to a corresponding container. The method may also include enforcing the stateful security policy against the container. The system and computer program product may include similar steps.

Abstract: A ducting system for a heating ventilation and air conditioning (HVAC) application includes a duct assembly having an inner duct member, and an outer duct member disposed around the inner duct such that the outer and inner duct members together define a pre-determined amount of space therebetween. The ducting system also includes a bonding and insulation composite that is disposed in the pre-determined amount of space between the inner and outer duct members to insulate the inner and outer duct members from each other yet adhesively bond with each of the inner and outer duct members for imparting structural rigidity to the duct assembly.

Abstract: Methods and formulations are provided for treating spinobulbar muscular atrophy in a subject in need thereof. By administering a therapeutically effective amount of a selective androgen receptor modulator or a small molecule such as 1-[2-(4-methylphenoxy)ethyl]-2-[(2-phenoxyethyl)sulfanyl]-1H-benzimidazole or a derivative, prodrug, or pharmaceutically acceptable salt thereof, one or more symptoms of spinobulbar muscular atrophy can be ameliorated. The effective amount can be effective to prevent or delay loss of body weight, a loss of mobility, and/or a loss of physical strength in the subject; to prevent or delay neurogenic atrophy and/or to prevent a loss of spinal cord motor neurons in the subject; to restore the frequency of type I myofibers to normal levels for a healthy subject; and/or to reverse testicular atrophy in the subject.

Abstract: A stackable filesystem that transparently tracks process file writes for forensic analysis. The filesystem comprises a base filesystem, and an overlay filesystem. Processes see the union of the upper and lower filesystems, but process writes are only reflected in the overlay. By providing per-process views of the filesystem using this stackable approach, a forensic analyzer can record a process's file-based activity—i.e., file creation, deletion, modification. These activities are then analyzed to identify indicators of compromise (IoCs). These indicators are then fed into a forensics analysis engine, which then quickly decides whether a subject (e.g., process, user) is malicious. If so, the system takes some proactive action to alert a proper authority, to quarantine the potential attack, or to provide other remediation. The approach enables forensic analysis without requiring file access mediation, or conducting system event-level collection and analysis, making it a lightweight, and non-intrusive solution.