Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: A blower includes a housing including an inlet and an outlet, a bearing-housing structure provided to the housing and adapted to rotatably support a rotor, a motor provided to the bearing-housing structure and adapted to drive the rotor, and an impeller provided to the rotor. The bearing-housing structure includes a bearing shaft having a bearing surface that rotatably supports the rotor. The bearing shaft provides only a single bearing of the non-ball bearing type for the rotor.

Abstract: A chair with a transom, a seat support, a back portion, and a combined rock and recline mechanism. The combined rock and recline mechanism has front and rear rocking arrangements configured to enable the seat support and back portion to together rock generally forward and rearward from a neutral position relative to the transom, and a recline arrangement that is configured such that the seat support is in a first at-rest position relative to the back portion when the back portion is in an upright position, and such that reclining the back portion rearwardly from the upright position toward a reclined position moves the seat support upward and rearward from the first at-rest position.

Abstract: A method includes receiving, by a computer system, information related to device health of an electronic device, determining, by the computer system, a health status of the electronic device based at least in part on the received information related to the device health of the electronic device, requesting, by a switch having a port connected to the electronic device, the health status of the electronic device from the computer system, receiving, by the computer system, the request for the health status of the electronic device from the switch, transmitting, by the computer system, the health status of the electronic device to the switch, evaluating, by the switch, the transmitted health status of the electronic device using network access rules associated corresponding to health statuses, and applying, by the switch, a network access control configuration to the port of the switch based on the evaluating the transmitted health status.

Abstract: A system including an injector, a press, and a robotic conveyance is used to form a physically foamed article of footwear component from a single-phase solution of a polymeric composition and a supercritical fluid. The parameters and features of the system are configured for the formation of the footwear component in an automated manner with enhanced throughput by the system.

Abstract: A computational method, apparatus and system for diagnostic and therapeutic prediction from multimodal data is provided for using machine learning to predict medical therapeutic methods using multimodal data. The computational method, apparatus and system for diagnostic and therapeutic prediction from multimodal data may include a biomarker and subtype identification aspect, multimodality aspect, machine learning aspect, and training aspect. A method for using machine learning to predict medical therapeutic methods, which may include targets, drugs, or combinations of drugs, using multimodal data using the computational system for diagnostic and therapeutic prediction from multimodal data is also provided.

Abstract: An electrosurgical connection unit for a surgical robot arm to connect an electrosurgical instrument attached to the arm to an electrosurgical generator. The electrosurgical connection unit includes an input port connectable to the electrosurgical generator, the input port configured to receive a driving electrosurgical signal and output one or more activation signals; an output port connectable to the electrosurgical instrument, the output port configured to output the driving electrosurgical signal received on the input port; one or more activation switch units, wherein activation of an activation switch unit causes an activation signal to be output from the input port indicating a driving electrosurgical signal with a desired waveform is to be activated; and a control unit configured to selectively activate one of the one or more activation switch units in response to a control signal.

Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.

Abstract: Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host.

Abstract: A glove box for a vehicle includes a bin having an upper rim and defining a storage cavity accessible via an opening defined by the upper rim. The glove box further includes a retainer pivotably coupled to the bin and operable to pivot relative to the bin between a first position and a second position. In the first position, a portion of the retainer is positioned within the storage cavity. In the second position, the retainer is positioned wholly outside of the storage cavity.

Abstract: Paper towel rolls that exhibit novel combinations of physical properties, such as Basis Weight, Roll Density, and Roll Diameter, such that the paper towel rolls meet consumers' needs, and method for making such novel paper towel rolls and marketing such novel paper towel rolls are provided.

Abstract: Devices, systems and methods for controlling a patient's body temperature by endovascular heat exchange.

Abstract: A process control system (PCS) includes a cable connection including physical cables including a first cable for connecting between a process controller and an I/O access device, and an independent second cable for connecting the process controller and a second node being the I/O access device or another device. The I/O access device is for coupling to I/O module(s) to receive an output of the I/O access device. An output of the I/O module is coupled to a field device coupled to processing equipment. The process controller and I/O access device each include a processor and memory that implement send and receive logic for communicating using any of multiple redundancy protocols including a first and a second redundant protocol. The cable connection is for supporting simultaneously communicating between the process controller and the second node utilizing both the first redundant protocol and the second redundant protocol.

Abstract: A vehicle is provided that includes a vehicle body defining a cabin interior, a plurality of seats located within the cabin interior, each seat having an adjustable seat base and an adjustable seat back, a monitoring system for detecting and monitoring a pet within the cabin interior, and a controller processing signals generated by the monitoring system and determining a location of the pet based on the monitored signals, the controller further controlling at least one of the adjustable seat base and adjustable seat back of a seat based on the determined location of the pet so that the seat is configured to accommodate the pet.

Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.

Abstract: A composition including a first color shifting pigment having a first color shift that extends from a starting color at normal through a plurality of colors as a viewing angle is increased to a final color, wherein the first color shift rotates counterclockwise relative to, and about, an origin of the L*a*b* color space; and a color filter that transmits a portion of the first color shift of the first color shifting pigment and absorbs a remainder of the first color shift of the first color shifting pigment; wherein the composition has a second color shift different from the first color shift; and wherein the second color shift has a first portion that rotates counterclockwise relative to the origin and a second portion that rotates clockwise relative to the origin is disclosed. A security device including the composition is included. A method of making the composition and a method of authenticating the security device are also disclosed.

Abstract: A search engine system generally includes a user interface in a computing environment configured to receive at least a first fragment from a user and a content display module configured to automatically generate an anticipated search result in the computing environment based on at least the first fragment. The content display module is configured to automatically display search results that include an arrangement of a plurality of visual content elements based on the anticipated search result. The content display module is configured to direct the user to content at one of a network and a local destination associated with one of the visual content elements selectable by the user with the user interface.

Abstract: Systems and methods are described in which the location of a tap on the body of a handheld device is determined in real time using data streams from an embedded inertial measurement unit (IMU). Taps may be generated by striking the handheld device with an object (e.g., a finger), or by moving the handheld device in a manner that causes it to strike another object. IMU accelerometer, gyroscopic and/or orientation (relative to the magnetic and/or gravitational pull of the earth) measurements are examined for signatures that distinguish a tap at a location on the body of the device compared with signal characteristics produced by taps at other locations. Neural network and/or numerical methods may be used to perform such classifications.

Abstract: Embodiments of a recombinant human Parainfluenza Virus (hPIV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the hPIV F ectodomain trimer and methods of producing the hPIV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or inhibiting a hPIV infection in a subject by administering a effective amount of the recombinant hPIV F ectodomain trimer to the subject.

Abstract: A nonwoven fabric. The nonwoven fabric can include a first surface and a second surface and a visually discernible pattern of three-dimensional features on one of the first or second surface. Each of the three-dimensional features can define a microzone comprising a first region and a second region. The first and second regions can have a difference in values for an intensive property.