Abstract: The disclosures herein relate to novel compounds of Formula (1a): and salts thereof, wherein W, Z, L, R1 and R2 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of disorders associated with CGRP receptors.

Abstract: The disclosures herein relate to novel compounds of Formula (1a): and salts thereof, wherein W, Z, L, R1 and R2 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of disorders associated with CGRP receptors.

Abstract: An arc-detection system for detecting an arc during an electrocautery surgical procedure may comprise a camera portion and an image processing controller portion. The camera portion may be sized for minimally invasive penetration into a patient's body. The camera portion may comprise a wide-angle lens having a field of view wider than 45 degrees and wider than a field of view of a conventional endoscopic camera system. The image processing controller portion may be configured to monitor images captured by the camera portion and configured to detect thermal changes to tissue at the surgical site.

Abstract: The disclosures herein relate to novel compounds of Formula (1a) or (1b) or a salt thereof, wherein R1, R2, R3, R4, R8, R9 and R10 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of disorders associated with GPR52 receptors.

Abstract: A surgical system may comprise a display device and an endoscope. The surgical system may also include a processing device configured to operate the surgical system to perform a process comprising receiving a source image and receiving a gaze location of a user of the surgical system. The process may also comprise determining a first region of the source image based on the gaze location. A second region of the source image partially surrounds the first region and includes a source distortion. The process may also comprise applying a distortion correction to the source image to generate a modified image by applying a first degree of distortion correction in the first region and a second degree of distortion correction in the second region. The second degree of distortion correction preserves the source distortion in a portion of the second region. The process may also comprise displaying the modified image.

Abstract: A surgical cannula includes a camera disposed at the distal end to permit visualization of tissue. A hinge pivotably couples the camera to the cannula and permits the camera to pivot from a first position at the distal end of the cannula to a second position different than the first position at the distal end of the cannula. Some implementations include a pointed distal tip that carries the camera. Some implementations include two cameras posed back to back.

Abstract: The disclosures herein relate to novel compounds of Formula (1); and salts thereof, wherein X, Y, R1, R2, R3 and R4 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of disorders associated with GPR52 receptors.

Abstract: A system comprises an elongate flexible catheter including a lumen extending along at least a portion of a longitudinal axis of the elongate flexible catheter and terminating at a distal opening of the elongate flexible catheter. The system further comprises a circuit assembly including a plurality of conductors wrapped in a spiral configuration around the elongate flexible catheter. At least one of the plurality of conductors of the circuit assembly is coupled to an electrode. The system further comprises at least one processor configured to determine a location of the elongate flexible catheter based on at least one signal received from the electrode.

Abstract: Systems and methods of presenting an image of a portion of a surgical scene on a display device associated with an endoscope include receiving, from the endoscope, a source image representing a view of the surgical scene as captured using the endoscope. The systems and methods further include devices configured to, by one or more processing devices, apply a distortion correction to at least a portion of the source image to generate a modified image, wherein the modified image includes a central region, and a peripheral region surrounding the central region, wherein a first degree of distortion correction in the central region is higher than a second degree of distortion correction in the peripheral region. The systems and methods further include devices configured to present the modified image on the display device associated with the endoscope.

Abstract: An imaging system and method includes a rolling shutter sensor that captures a plurality of images of a scene, a time-varying illumination source that illuminates the scene, and a processor that receives the plurality of images from the rolling shutter sensor and separates the plurality of images into a plurality of feeds. Each of the plurality of images is captured as a series of lines. The rolling shutter sensor and the time-varying illumination source are operated synchronously to cause a plurality of on-cadence lines of the rolling shutter sensor to receive more illumination from the time-varying illumination source than a plurality of off-cadence lines of the rolling shutter sensor. Each of the plurality of feeds has a different contribution of the time-varying illumination source to an overall illumination of the scene.

Abstract: In vivo visualization systems are described which facilitate tissue treatment by a user in utilizing real time visualized tissue images with generated three-dimensional models of the tissue region of interest, such as the left atrial chamber of a subject's heart. Directional indicators on the visualized tissue as well as the imaging systems may be utilized while other variations may utilize image rotation or manipulation of visualized tissue regions to facilitate catheter control. Moreover, visualized tissue regions may be combined with imaged tissue regions as well as navigational information to further facilitate tissue treatments.

Abstract: A tissue treatment assembly comprising an elongate flexible energy delivery device extending along a longitudinal axis and terminating at a distal opening and a circuit assembly including a plurality of conductors wrapped in a spiral configuration around the elongate flexible energy delivery device.

Abstract: The present disclosure relates to nanobodies, such as defined by SEQ ID NOS: 1-54, which may be encoded by SEQ ID NOS: 55-110, and which are capable of specifically binding glycoprotein VI (GPVI), as well as uses thereof, which include therapeutic and/or imaging uses.

Abstract: A computer implemented method comprises receiving a model of a tissue region, steering a distal end of a catheter within a body to a first area of a tissue region, and obtaining a first image from the distal end of the catheter of the first area of the tissue region. The method further comprises mapping the first image of the first area of the tissue region to the model of the tissue region and displaying the first image of the first area of the tissue region on the model of the tissue region.

Abstract: The disclosures herein relate to novel compounds of Formula (1): or a salt thereof, wherein Q, V, L, W, R1 and R2 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of disorders associated with GPR52 receptors.

Abstract: A system prioritizes the rendering and streaming of image data based on risk maps that predict change in a three-dimensional (“3D”) environment. The system receives primitives that are distributed across a 3D space to represent the 3D environment. The system generates a first image based on primitives that fall within a first view frustum, and generates a risk map with a risk value for each particular pixel of the first image. Each risk value quantifies a probability that a pixel of the first image associated with that risk value changes as a result of changing the first view frustum to a second view frustum. The system then performs an out-of-order rendering of primitives that fall within the second view frustum based on the risk value for each first image pixel that is replaced in a second image with a rendered primitive from the second view frustum.

Abstract: An imaging system and method includes a rolling shutter sensor that captures a plurality of images of a scene, a time-varying illumination source that illuminates the scene, and a processor that receives the plurality of images from the rolling shutter sensor and separates the plurality of images into a plurality of feeds. Each of the plurality of images is captured as a series of lines. The rolling shutter sensor and the time-varying illumination source are operated synchronously to cause a plurality of on-cadence lines of the rolling shutter sensor to receive more illumination from the time-varying illumination source than a plurality of off-cadence lines of the rolling shutter sensor. Each of the plurality of feeds has a different contribution of the time-varying illumination source to an overall illumination of the scene.

Abstract: A method is disclosed which comprises accessing a detector model that is trained in parallel with an operator model and an attacker model using a reinforcement learning technique based on iteratively simulating scenarios of operation of an environment to generate training data and learning weights of the models based on the simulated training data. The simulating of a scenario is based on the last learned weights of the models. The method further comprises, during operation of the environment, applying the detector model to an operator action, a prior observation of state of the environment from prior to taking the operator action, and a current observation of the environment from after taking the operator action, to detect whether an attack on the environment has occurred.

Abstract: An arc-detection system for detecting an arc during an electrocautery surgical procedure may comprise a camera portion and an image processing controller portion. The camera portion may be sized for minimally invasive penetration into a patient’s body. The camera portion may comprise a wide-angle lens having a field of view wider than 45 degrees and wider than a field of view of a conventional endoscopic camera system. The image processing controller portion may be configured to monitor images captured by the camera portion and configured to detect thermal changes to tissue at the surgical site.

Abstract: An ablation probe tip (100) having a shaft (102) with an insertion end (104). The shaft (102) includes a coaxial antenna (110). A center of ablation (124) is located within the shaft (102) near the insertion end (104). A heat transfer layer (130) surrounds the coaxial antenna (110). A thermal reservoir (134) at least partially surrounds the heat transfer layer (130). A method for using the ablation probe tip (100) includes predetermining an optimal temperature for the heat transfer layer (130), and the thermal reservoir (134) cooling the heat transfer layer (130) to no higher than the optimal temperature. The ablation probe tip (100) may be part of an ablation probe system (50) that includes an ablation source (60) that provides ablation means (62) to the ablation probe tip (100).