Abstract: Methods of making orally available softgels includes pre-wetting a probiotic with an edible oil to produce a wetted supplement, wherein the edible oil is present in a range of 25% to 75% by weight of a total weight of the probiotic and edible oil, heating the wetted supplement to a temperature in a range of 35° C. to 40° C., blending the wetted supplement and a molten chocolate component together to produce a liquid fill material, encapsulating the liquid fill material in a softgel coating to produce an orally available softgel, and cooling the orally available softgel to have a softgel capsule shell comprising 5% to 15% by weight water. The fill material is a solid at room temperature in the cooled orally available softgel.

Abstract: A method is provided by which payments for assets are recorded using blockchain transactions, and verified based on immutable logs associated with the transactions.

Abstract: Various embodiments herein provide a light device that is selectively attachable to another device. For example, in some embodiments, the light device may be selectively attachable to a glove wrap that may be worn on a hand of a user. The light device may include a housing and a light unit coupled to the housing. The light unit may be selectively extendable from the housing, e.g., via a flexible neck. The light device may include an engagement mechanism to selectively attach the light device to the other device in any of multiple configurations. Other embodiments may be described and claimed.

Abstract: The invention comprises an agent for use in medicine, wherein the agent comprises a compound of Formula (I): B-L-B? wherein: B and B? are independently selected from groups of formula (B-I) wherein: Z is selected from —COOH, —CH2COOH, —PO(OH)(OR1), or —CH2PO(OH) (OR1), wherein R1 is H or a phosphate protecting group; W is an alicyclic amine group having from 5 to 12 carbon atoms and at least one amine nitrogen atom; W? is H, or W? is linked to W to form said alicyclic amine group; and Y is selected from —NH—, —N(CH3)—, —CH2—, —NHCO—, —CH2CONH—, —CONH—, CH2NHCO—, or —NHCH2—; and L is a linker group.

Abstract: An agent for use in medicine, wherein the agent comprises a compound of Formula (I): wherein Ar is an aryl linker group, for example a 1,4-phenyl group, including individual pharmaceutically acceptable salts, solvates, prodrugs or derivatives thereof. The compounds of Formula (I) are inhibitors of human C-reactive protein (CRP) and may be used for the treatment of medical conditions mediated by CRP. Also provided are methods of making the compounds of Formula (I) and chemical intermediates thereof.

Abstract: The disclosed embodiments relate to a system that compactly stores time-series sensor signals. During operation, the system receives original time-series signals comprising sequences of observations obtained from sensors in a monitored system. Next, the system formulizes the original time-series sensor signals to produce a set of equations, which can be used to generate synthetic time-series signals having the same correlation structure and the same stochastic properties as the original time-series signals. Finally, the system stores the formulized time-series sensor signals in place of the original time-series sensor signals.

Abstract: Some embodiments of the time resilient system and methods disclosed herein can be configured to detect and defend against invalid time signals. According to various embodiments of the disclosed technology, the time resilient system include a receiver for collecting time signals sourced from an external clock. By way of example only, the external clock may be a high precision clock housed within a Global Positioning System. Other embodiments may include an internal clock calibrated to a time reflected on the external clock so that the internal clock and the external clock are synchronized. Additionally, a controller may monitor changes in time signals of the external over a period of time against the internal clock, where the system is alerted of a timing attack when the time signals collected from the receiver deviate a pre-determined time range with the time of the internal clock.

Abstract: During operation, the system obtains a training dataset during a training mode, wherein the training dataset includes counts of actions performed by users while operating applications in the computer system. Next, the system uses the training dataset to produce corresponding per-action datasets. The system then cleanses the training dataset based on counts of actions in the per-action datasets to produce a cleansed training dataset, and uses the cleansed training dataset to produce corresponding per-user datasets. Next, the system trains per-user models based on the per-user datasets to detect anomalous actions of users. The system then obtains a surveillance dataset during a surveillance mode, wherein the surveillance dataset includes counts of actions performed by users while operating applications in the computer system. Next, the system uses the trained per-user models to detect anomalous actions in the surveillance dataset. Finally, when an anomalous action is detected, the system triggers an alert.

Abstract: Systems, methods, and other embodiments associated with multi-distance tri-point arbitration are described. In one embodiment, a method includes using a K different distance functions, calculating K per-distance tri-point arbitration similarities between a pair of data points with respect to an arbiter point. A multi-distance tri-point arbitration similarity S between the data points is calculated by determining that the data points are similar when a dominating number of the K per-distance tri-point arbitration similarities indicate that the data points are similar; and determining that the data points are dissimilar when a dominating number of the K per-distance tri-point arbitration similarities indicate that the data points are dissimilar. The multi-distance tri-point arbitration similarity is associated with the data points for use in future processing.

Abstract: The disclosed embodiments relate to a system that facilitates development of machine-learning techniques to perform prognostic-surveillance operations on time-series data from a monitored system, such as a power plant and associated power-distribution system. During operation, the system receives original time-series signals comprising sequences of observations obtained from sensors in the monitored system. Next, the system decomposes the original time-series signals into deterministic and stochastic components. The system then uses the deterministic and stochastic components to produce synthetic time-series signals, which are statistically indistinguishable from the original time-series signals. Finally, the system enables a developer to use the synthetic time-series signals to develop machine-learning (ML) techniques to perform prognostic-surveillance operations on subsequently received time-series signals from the monitored system.

Abstract: In an embodiment, an apparatus includes one or more probes, a tip, a pin, and a measurement device. The one or more probes may be configured for insertion through an aperture in a component. The tip may be slidably engaged with the one or more probes and include a first end configured to contact a first surface of the component. The first end of the tip may be conically shaped. The pin may be slidably engaged with the one or more probes and include a first end configured for insertion into the aperture in the component such that the one or more probes are configured to contact a second surface of the component. The pin may be configured to move between a first position and a second position. An axis of the pin may be substantially aligned with an axis of the tip. The measurement device may be coupled to the tip and configured to measure a value indicating a grip length.

Abstract: An joint orthosis such as an ankle foot orthosis for controlling joint movement is disclosed, and a method of manufacture. The joint orthosis comprises: a hinge for controlling joint movement in at least one direction; wherein the hinge comprises at least one resiliently deformable portion, and wherein the resiliently deformable portion is configured to resiliently deform in response to at least the joint movement in the at least one direction, to resist further joint movement in the at least one direction.

Abstract: The system obtains a multimodal dataset containing different types of data gathered during operation of the computer system, wherein the multimodal dataset includes time-series data for different variables associated with operation of the computer system. Next, the system forms a set of feature groups from the multimodal dataset, wherein each feature group comprises variables from the multimodal dataset containing the same type of data. The system then computes a tripoint similarity matrix for each feature group, and aggregates the tripoint similarity matrices for the feature groups to produce a crossmodal tripoint similarity matrix. Next, the system uses the crossmodal tripoint similarity matrix to cluster the multimodal dataset to form a model. The system then performs prognostic-surveillance operations on real-time multimodal data received from the computer system, wherein the prognostic-surveillance operations use the model as a classifier to detect anomalies.

Abstract: Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of diseases and disorder such as learning, cognitive activities, and analgesia, particularly in alleviating and/or reducing neuropathic pain. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.

Abstract: An electric cooking grill has a grate supported on a top side of a grill body having a sidewall. The grate is formed with a plurality of diagonally running grate members on opposing sides of gaps therebetween. A centrally located exhaust housing has curved sidewalls forming an elliptical shape of the exhaust housing. Exhaust openings running along the elliptically curved sidewalls communicate negative pressure to recessed air flowpaths in the gaps to remove smoke with an air filter.

Abstract: In an embodiment, an apparatus includes one or more probes, a tip, a pin, and a measurement device. The one or more probes may be configured for insertion through an aperture in a component. The tip may be slidably engaged with the one or more probes and include a first end configured to contact a first surface of the component. The first end of the tip may be conically shaped. The pin may be slidably engaged with the one or more probes and include a first end configured for insertion into the aperture in the component such that the one or more probes are configured to contact a second surface of the component. The pin may be configured to move between a first position and a second position. An axis of the pin may be substantially aligned with an axis of the tip. The measurement device may be coupled to the tip and configured to measure a value indicating a grip length.

Abstract: The present invention provides for a squeeze handle for an ophthalmic instrument having elongate body with resiliently-biased squeeze elements, wherein a conduit is provided within the elongate body to allow for fluid communication between an opening provided in an outer wall of elongate body and a tool to be in operative engagement with the handle and the squeeze elements, and to a related method of cleaning an ophthalmic instrument having resiliently biased squeeze elements on an elongate handle body, and including the steps of introducing, by way of an opening provided in an outer wall of the elongate body, fluid under pressure into a conduit provided within the elongate body; and allowing for flow of the fluid along the conduit to a tool in operative engagement with the elongate handle and squeeze elements; for cleaning the tool.