Patents by Inventor Paul Abato

Paul Abato has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUBSTITUTED TETRACYCLINE COMPOUNDS
    Publication number: 20210395189
    Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms.
    Type: Application
    Filed: January 4, 2021
    Publication date: December 23, 2021
    Inventors: Paul Abato, Todd Bowser
  • SUBSTITUTED TETRACYCLINE COMPOUNDS
    Publication number: 20170305840
    Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: December 9, 2016
    Publication date: October 26, 2017
    Inventors: Mark L. Nelson, Kwasi Ohemeng, Paul Abato, Victor Amoo, Haregewein Assefa, Joel Berniac, Beena Bhatia, Todd Bowser, Jackson Chen, Mark Grier, Laura Honeyman, Mohamed Y. Ismail, Oak K. Kim, Jude Mathews, Rachid Mechiche
  • SUBSTITUTED TETRACYCLINE COMPOUNDS
    Publication number: 20160046561
    Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms.
    Type: Application
    Filed: March 26, 2015
    Publication date: February 18, 2016
    Inventors: Paul Abato, Todd Bowser
  • 7-DISUBSTITUTED-PHENYL TETRACYCLINE DERIVATIVES
    Publication number: 20150166470
    Abstract: 7-Disubstituted-phenyl tetracycline compounds are disclosed herein. Also disclosed is a method for treatment or prevention of spinal muscular atrophy using the 7-disubstituted-phenyl tetracycline compounds. This invention also relates to a method for treating or preventing a subject having spinal muscular atrophy. The method includes administering to the subject an effective amount of a tetracycline compound of formula (1), such that the spinal muscular atrophy is treated or prevented. Advantageously, the tetracycline compounds used in this method of the invention have one or more of the following characteristics: 1) potency in modulating mRNA splicing, 2) potency in modulating SMN protein levels, 3) central nervous system (CNS) and/pr brain penetration, 4) decreased phototoxic properties and 5) decreased antibacterial properties.
    Type: Application
    Filed: May 30, 2013
    Publication date: June 18, 2015
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Todd Bowser, Paul Abato
  • Substituted tetracycline compounds
    Patent number: 9012433
    Abstract: The present invention pertains to tetracycline compounds of formula (VIIa): R5*, R5*?, R7r*, and R9m* are defined herein. These tetracycline compounds can be used to treat tetracycline compound-responsive states, such as multiple sclerosis and rheumatoid arthritis.
    Type: Grant
    Filed: November 27, 2012
    Date of Patent: April 21, 2015
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Paul Abato, Todd Bowser
  • SUBSTITUTED TETRACYCLINE COMPOUNDS
    Publication number: 20150045329
    Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: May 19, 2014
    Publication date: February 12, 2015
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Kwasi Ohemeng, Paul Abato, Victor Amoo, Haregewein Assefa, Joel Berniac, Beena Bhatia, Todd Bowser, Jackson Chen, Mark Grier, Laura Honeyman, Mohamed Y. Ismail, Oak K. Kim, Jude Mathews, Rachid Mechiche
  • SUBSTITUTED TETRACYCLINE COMPOUNDS
    Publication number: 20140155357
    Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: June 14, 2013
    Publication date: June 5, 2014
    Inventors: Paul Abato, Haregewein Assefa, Joel Berniac, Beena Bhatia, Todd Bowser, Jackson Chen, Mark Grier, Laura Honeyman, Mohamed Y. Ismail, Mark L. Nelson, Kwasi Ohemeng, Jingwen Pan
  • Substituted tetracycline compounds
    Patent number: 8466132
    Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: October 25, 2005
    Date of Patent: June 18, 2013
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Paul Abato, Haregewein Assefa, Joel Berniac, Beena Bhatia, Todd Bowser, Jackson Chen, Mark Grier, Laura Honeyman, Mohamed Y. Ismail, Mark L. Nelson, Kwasi Ohemeng, Jingwen Pan
  • Substituted Tetracycline Compounds
    Publication number: 20110086822
    Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: October 8, 2010
    Publication date: April 14, 2011
    Inventors: Mark L. Nelson, Kwasi Ohemeng, Roger Frechette, Paul Abato, Victor Amoo, Upul Bandarage, Joel Berniac, Beena Bhatia, Jackson Chen, Mohamed Y. Ismail, Oak Kim, Laura Honeyman, Rachid Mechiche, Andre Pearson, Laxma Reddy Nagavelli, Paul Sheahan, Atul K. Verma, Peter Viski, Tadeusz Warchol
  • Substituted Tetracycline Compounds
    Publication number: 20100305072
    Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms.
    Type: Application
    Filed: December 21, 2007
    Publication date: December 2, 2010
    Inventors: Oak K. Kim, Mark L. Nelson, Paul Abato, Haregewein Assefa, Joel Bernaiac, Mohamed Y. Ismail, Todd Bowser, Mark Grier, Beena Bhatia, Atul K. Verma, Laura Honeyman, Jingwen Pan
  • TETRACYCLINE COMPOUNDS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS AND RELATED METHODS OF TREATMENT
    Publication number: 20100190755
    Abstract: The present invention pertains, at least in part, to substituted tetracycline compounds. The present invention also pertains to methods for treating rheumatoid arthritis in a subject, comprising administering to the subject a tetracycline compound of the invention.
    Type: Application
    Filed: September 21, 2009
    Publication date: July 29, 2010
    Inventors: Paul Abato, Todd Bowser, Paul Higgins, Atul K. Verma, Jie Zhang-Hoover
  • Amino-methyl substituted tetracycline compounds
    Patent number: 7326696
    Abstract: Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.
    Type: Grant
    Filed: December 15, 2003
    Date of Patent: February 5, 2008
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Kwasi Ohemeng, Roger Frechette, Paul Abato, Victor Amoo, Haregewein Assefa, Joel Berniac, Beena Bhatia, Todd Bowser, Jackson Chen, Laura Honeyman, Mohamed Y. Ismail, Oak Kim, Rachid Mechiche, N. Laxma Reddy, Atul K. Verma, Peter Viski, Tadeusz Warchol, Ivan Yanachkov
  • Amino-methyl substituted tetracycline compounds
    Publication number: 20080015169
    Abstract: Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.
    Type: Application
    Filed: June 5, 2007
    Publication date: January 17, 2008
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Mark Nelson, Kwasi Ohemeng, Roger Frechette, Paul Abato, Victor Amoo, Haregewein Assefa, Joel Berniac, Beena Bhatia, Todd Bowser, Jackson Chen, Laura Honeyman, Mohamed Ismail, Oak Kim, Rachid Mechiche, N. Reddy, Atul Verma, Peter Viski, Tadeusz Warchol, Ivan Yanachkov
  • 10-substituted tetracyclines and methods of use thereof
    Publication number: 20070093455
    Abstract: 10-Substituted tetracycline compounds are described.
    Type: Application
    Filed: July 21, 2006
    Publication date: April 26, 2007
    Inventors: Paul Abato, Haregewein Assefa, Joel Berniac, Todd Bowser, Jackson Chen, Mark Grier, Laura Honeyman
  • Substituted tetracycline compounds
    Publication number: 20060166945
    Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: October 25, 2005
    Publication date: July 27, 2006
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Paul Abato, Haregewein Assefa, Joel Berniac, Beena Bhatia, Todd Bowser, Jackson Chen, Mark Grier, Laura Honeyman, Mohamed Ismail, Mark Nelson, Kwasi Ohemeng, Jingwen Pan
  • Substituted tetracycline compounds
    Publication number: 20050143352
    Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: June 25, 2004
    Publication date: June 30, 2005
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Mark Nelson, Kwasi Ohemeng, Paul Abato, Victor Amoo, Haregewein Assefa, Joel Berniac, Beena Bhatia, Todd Bowser, Jackson Chen, Mark Grier, Laura Honeyman, Mohamed Ismail, Oak Kim, Jude Mathews, Rachid Mechiche
  • Substituted tetracycline compounds
    Publication number: 20050038002
    Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: December 18, 2003
    Publication date: February 17, 2005
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Mark Nelson, Kwasi Ohemeng, Roger Frechette, Paul Abato, Victor Amoo, Upul Bandarage, Joel Berniac, Beena Bhatia, Jackson Chen, Mohamed Ismail, Oak Kim, Laura Honeyman, Rachid Mechiche, Andre Pearson, Laxma Nagavelli, Paul Sheahan, Atul Verma, Peter Viski, Tadeusz Warchol
  • Amino-methyl substituted tetracycline compounds
    Publication number: 20050026875
    Abstract: Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.
    Type: Application
    Filed: December 15, 2003
    Publication date: February 3, 2005
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Mark Nelson, Kwasi Ohemeng, Roger Frechette, Paul Abato, Victor Amoo, Haregewein Assefa, Joel Berniac, Beena Bhatia, Todd Bowser, Jackson Chen, Laura Honeyman, Mohamed Ismail, Oak Kim, Rachid Mechiche, N. Reddy, Atul Verma, Peter Viski, Tadeusz Warchol, Ivan Yanachkov