Abstract: Examples of enterprise management using managed virtual machines (VMs) are described. In one example, a virtual machine base image is validated to comply with a plurality of managed virtual machine packaging rules of a management service. Managed virtual machine configuration parameters are written to a managed virtual machine configuration file of a managed virtual machine. The managed virtual machine includes a management component that implements instructions from a management service. A managed virtual machine package file is generated to include the managed virtual machine configuration file and enterprise-specific enterprise resources identified from the management service based on the enterprise identifier.

Abstract: The present invention relates to a method for identification of common patient-spanning tumor-specific T cell receptors (TCRs) and their corresponding antigens. The invention also relates to these TCR sequences, a nucleic acid encoding the TCR, and a T cell comprising the TCR and/or the encoding nucleic acid.

Abstract: The present invention relates to a binding molecule which is at least bispecific comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope cluster 3 of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.

Abstract: The present invention relates to a binding molecule which is at least bispecific comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope cluster 3 of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.

Abstract: The present invention relates to novel tri-specific binding molecules. The invention also relates to nucleic acids encoding such binding molecules; to methods for preparing such binding molecules; to host cells expressing or capable of expressing such binding molecules; to compositions comprising such binding molecules; and to uses of such binding molecules or such compositions, in particular for therapeutic purposes in the field of cancer diseases.

Abstract: A rotor blade configured to be installed on a rotary-wing aircraft includes a main blade body including an inboard end configured to be coupled to a rotor blade hub and an outboard end. The rotor blade includes a blade tip removably coupled to the outboard end of the main blade body, the blade tip including an inner cavity. The rotor blade further includes a tip block including an inboard portion coupled to the outboard end of the main blade body and a cantilevered portion extending beyond the outboard end of the rotor blade and into the inner cavity of the blade tip.

Abstract: The present disclosure provides solid forms of resiquimod useful, e.g., as an immunomodulatory payload component of certain biomaterials (e.g., hydrogels) and/or formulations for administration to subjects.

Abstract: A rotor blade includes a spar with forward end, an aft end, and a substantially oval cross-section. The cross-section includes an upper portion tapering from a first thickness to a smaller, second thickness beginning between about 55% and about 65% of the distance to the aft end from the forward end and ending between about 65% and about 75% of the distance to the aft end measured from the forward end, and a lower portion tapering from a third thickness to a smaller, fourth thickness beginning between about 55% and about 65% of the distance to the aft end from the forward end and ending between about 65% and about 75% of the distance to the aft end measured from the forward end. The rotor blade further includes an upper blade skin, a lower blade skin, and a leading edge sheath.

Abstract: The present invention relates to novel DLL3/CD3 binding proteins. The invention also relates to nucleic acids encoding such proteins; to methods for preparing such proteins; to host cells expressing or capable of expressing such proteins; to compositions comprising such proteins; and to uses of such proteins or such compositions, in particular for therapeutic purposes in the field of cancer diseases.

Abstract: A device comprises an ultrasound probe housing having an ambient side and a body side wherein the ultrasound probe housing contains a plurality of ultrasound probes configured to produce images of inside the body of a patient. The device may further include a needle guide assembly connected to the housing that receives a needle for insertion into the body of the patient so that the needle can be visualized by the ultrasonic probes in real time. Each of a first set of the ultrasound probes is positioned non-perpendicular to the body side of the ultrasound probe housing such that a direction of ultrasound waves generated by each of the first set of ultrasound probes is toward a site of penetration of the needle into the body of the patient.

Abstract: Systems and methods for sensor emplacement using unmanned aircraft systems (UASs). In some examples, a UAS includes a propulsion system and a sensor emplacement system including an auger and one or more motors. The UAS includes a control system configuring for controlling the propulsion system to land the UAS at a sensor emplacement site and controlling the one or more motors of the sensor emplacement system to drive the auger into soil at the sensor emplacement site. The control system is configured for measuring one or more augering parameters from the sensor emplacement system; and determining, using an autonomous system trained on soil data and augering data, one or more soil classification values for the soil based on the one or more augering parameters.

Abstract: Examples of enterprise management using managed virtual machines are described. A host user context configuration can be received from a host management agent. The host user context configuration can include one or more policies. A managed virtual machine user context configuration can be received from a guest management agent within a managed virtual machine. A portion of the host user context configuration can be processed using a translation matrix to identify a configuration service provider (CSP)-based profile that is mapped to a policy from the host user context configuration. A command to enforce the CSP-based profile on the managed virtual machine can be transmitted.

Abstract: A rotor blade configured to be installed on a rotary-wing aircraft includes a main blade body including an inboard end configured to be coupled to a rotor blade hub and an outboard end. The rotor blade includes a blade tip removably coupled to the outboard end of the main blade body, the blade tip including an inner cavity. The rotor blade further includes a tip block including an inboard portion coupled to the outboard end of the main blade body and a cantilevered portion extending beyond the outboard end of the rotor blade and into the inner cavity of the blade tip.

Abstract: A rotor blade for a rotary wing aircraft includes a leading edge and a trailing edge defining a chordwise direction. The leading edge defines a forward end of the rotor blade and the trailing edge defines an aft end of the rotor blade. The rotor blade has a center of gravity and an aerodynamic center along the chordwise direction. The center of gravity is aft of the aerodynamic center.

Abstract: A device comprises an ultrasound probe housing that has an ambient side and a body side and contains ultrasound probes configured to produce images of inside the body of a patient. The device may further include a needle guide assembly connected to the housing that receives a needle for insertion into the body of the patient so that the needle can be visualized by the ultrasonic probes in real time. Each of a first subset of the ultrasound probes is positioned such that a direction of ultrasound waves generated thereby is through the body side and perpendicular to the body side. Each of a second subset of the ultrasound probes is positioned non-perpendicular to the body side such that a direction of ultrasound waves generated by each of the second subset of ultrasound probes is toward a site of penetration of the needle into the body of the patient.

Abstract: A patient-wearable device for detecting a subpulse of a patient and determining a pulse condition based thereon, and related systems, methods and computer program products. The device includes a base layer comprising a printed circuit board (PCB) and electronics connected thereto, and an adhesive layer connected to the base layer. The electronics may include one or more sensors that generate sensor data, a computer that processes the sensor data to determine the pulse condition of the patient, and a user interface (UI) component that generates a user-perceptible indication of the determined pulse condition. In alternate embodiments, the computer and the UI component may be external to the device and the device may communicate the sensor data to the computer via wired or wireless connection. In further embodiments, multiple devices may be attached to the patient and concurrently transmit raw or processed sensor data to facilitate determination of the pulse condition.

Abstract: Various examples for discovering policy bindings between group policy rules in a legacy management framework and unified endpoint management rules that are utilized in a modern mobile device management (MDM) device management framework. A configuration state view can allow an administrator to understand inconsistencies or conflicts between group policy rules and UEM rules.

Abstract: A fluid distribution system that uses a hovering distribution device and methods for using such a system are provided. In one example, the system may include a reel that provides a hose for the hovering distribution device. The hovering distribution device receives pressurized fluid from the hose, and includes at least one nozzle configured to distribute the pressurized fluid and provide lift for the hovering distribution device using the pressurized fluid. A control system may be configured to execute a fluid distribution plan by controlling at least one of a position and an orientation of the hovering distribution device in a three dimensional space using a direction of the nozzle.

Abstract: Provided are systems and methods for managing a level of heat provided by a processing module and a heating mechanism. In one example, a method includes determining, by a system such as a management control system, that a demand for water from a hot water reservoir is increasing. The hot water reservoir may serve as a heat sink for a processing module and may include a heating mechanism adapted to provide heat to the hot water reservoir separately from the processing module. A determination may be made as to whether the processing module is able to produce enough heat to meet the demand. If the processing module is not able to produce enough heat to meet the demand, the heat output of the heating mechanism may be increased to provide additional heat to the water in the hot water reservoir.

Abstract: Examples of enterprise management using managed virtual machines are described. Virtual machine files can be extracted from a virtual machine package and stored on a host device. The virtual machine files can include a managed virtual machine configuration file, an NVRAM file, and a virtual disk file, as well as other files. A digital signature of the managed virtual machine package can be verified. The digital signature can be based on the managed virtual machine configuration file, the NVRAM file, and a virtual disk file. The managed virtual machine can be added to a virtual machine inventory of the host desktop hypervisor and executed.