Abstract: The present disclosure provides technologies related to certain polymer combination preparations and uses thereof. In many embodiments, such polymer combination preparations are temperature-responsive. In some embodiments, such polymer combination preparations may be useful as immunomodulatory biomaterials, e.g, to induce innate immunity or to resolve inflammation (e.g.; immunosuppressive inflammation). In some embodiments, such polymer combination preparations may be useful to formulate compositions comprising active agent(s).