Patents by Inventor Paul Adriaan Van Der Schaaf
Paul Adriaan Van Der Schaaf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20030114686Abstract: The present invention is directed to new crystalline forms of Atorvastatin calcium (2:1), referred to hereinafter as polymorphic Forms X, A, B1, B2, C, D and E. Furthermore, the present invention is directed to processes for the preparation of these crystalline forms and pharmaceutical compositions comprising the crystalline forms.Type: ApplicationFiled: October 7, 2002Publication date: June 19, 2003Inventors: Paul Adriaan Van Der Schaaf, Fritz Blatter, Martin Szelagiewicz, Kai-Uwe Schoning
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Publication number: 20030114711Abstract: Disclosed is a process for the preparation of a compound of formula 1Type: ApplicationFiled: October 15, 2002Publication date: June 19, 2003Inventors: Niranjan Paingankar, Vilas Mumbaikar, Vadiraj S Ekkundi, Hans-Peter Jalett, Urs Siegrist, Paul Adriaan Van Der Schaaf, Frank Bienewald, Martin Studer, Stefan Burkhardt
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Publication number: 20030105359Abstract: Crystalline forms of Venlafaxine hydrochloride were found, referred to hereinafter as polymorphic Forms A, B and D. Furthermore, the present invention is directed to processes for the preparation of these crystalline forms and pharmaceutical compositions comprising the crystalline forms.Type: ApplicationFiled: October 1, 2002Publication date: June 5, 2003Inventors: Paul Adriaan Van Der Schaaf, Claudia Marcolli, Martin Szelagiewicz, Beat Freiermuth
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Publication number: 20030032666Abstract: Novel crystalline forms of Fluvastatin sodium hydrates were found, referred to hereinafter as polymorphic Forms C, D, E and F. Furthermore, the present invention is directed to processes for the preparation of these crystalline forms, a process for the preparation of highly crystalline Fluvastatin sodium Form A, and pharmaceutical compositions comprising the crystalline forms.Type: ApplicationFiled: July 30, 2002Publication date: February 13, 2003Inventors: Paul Adriaan Van Der Schaaf, Claudia Marcolli, Martin Szelagiewicz, Andreas Burkhard, Heinz Wolleb, Annemarie Wolleb
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Patent number: 6465554Abstract: The invention relates to compositions of hexacoordinated ruthenium and osmium carbenes with a carbonyl group as ligand and a vinyl group as substituent on the carbene group as catalysts for the photoinduced ring-opening metathesis of strained cycloolefins. It also relates to novel hexacoordinated ruthenium and osmium carbenes having a carbonyl group as ligand and a vinyl group as substituent on the carbene group, to compositions of the catalyst with cycloolefins, and to the polymerization process.Type: GrantFiled: September 25, 2000Date of Patent: October 15, 2002Assignee: Ciba Specialty Chemicals CorporationInventors: Paul Adriaan Van Der Schaaf, Roman Kolly, Andreas Mühlebach, Andreas Hafner
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Patent number: 6417363Abstract: Penta- and hexa-coordinated, bridged ruthenium and osmium catalysts of the formula wherein Me is ruthenium or osmium; L1 and L2 are neutral ligands having electron donor properties; X is an anionic ligand; Y is oxygen or sulphur; A is a direct bond, C1-C4alkylene or C2-C4alkylidene; Z is a direct bond, oxygen, sulphur or the groups wherein R1 and R2 are hydrogen or hydrocarbon radicals; their preparation and their us in the synthesis of polymers, in the ring-closure metathesis of diolefins, in the cross metathesis of olefins and in the isomerisation of olefins are disclosed.Type: GrantFiled: May 26, 2000Date of Patent: July 9, 2002Assignee: Ciba Specialty Chemicals CorporationInventors: Paul Adriaan Van Der Schaaf, Andreas Mühlebach, Andreas Hafner, Roman Kolly
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Patent number: 6407190Abstract: The invention relates to penta- and hexacoordinated ruthenium and osmium carbene catalysts, in which a sulfur, oxygen or nitrogen atom is attached to the carbene group which is coordinated with the central ruthenium or osmium atom, to their preparation and to their use for synthesizing polymers, for ring-closing metathesis of olefins and for isomerizing olefins.Type: GrantFiled: December 15, 1999Date of Patent: June 18, 2002Assignee: Ciba Specialty Chemicals CorporationInventors: Paul Adriaan Van Der Schaaf, Andreas Hafner, Andreas Mühlebach
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Patent number: 6323295Abstract: Composition comprising (a) catalytic amounts of a one-component catalyst for metathesis polymerization and (b) at least one polymer with strained cycloalkenylene radicals bonded to the polymer backbone via a divalent bridge group, alone or as a mixture with strained cycloolefins. The composition can be polymerized thermally or photochemically by metathesis polymerization and is suitable for the production of shaped articles, coatings and relief images. The polymers (b) are likewise claimed.Type: GrantFiled: August 6, 1997Date of Patent: November 27, 2001Assignee: Ciba Specialty Chemicals CorporationInventors: Andreas Mühlebach, Andreas Hafner, Paul Adriaan Van Der Schaaf
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Patent number: 6306987Abstract: Disclosed is a compound of formula (I), and its use in preparing metathesis polymers of dicyclopentadiene and/or other strained cycloolefins in which Me is ruthenium or osmium; X1 and X2 independently of one another are anionic ligands, or X1 and X2 together are a bis-anionic ligand; Y is oxygen, sulfur or the groups —NR7— or —PR7—, where R7 is hydrogen or a substituent selected from the group C1-C6alkyl, C6-C13aralkyl, sulfonyl and —C(═O)Rs2 and Rs2 is hydrogen or a substituent selected from the group C1-C12alkyl, C2-C12alkenyl, C3-C12cycloalkyl, C3-C12cycloalkenyl, C2-C11heterocycloalkyl, C2-C11heterocycloalkenyl, C5-C12aryl, C1-C9heteroaryl, C6-C14aralkyl, C2-C13heteroaralkyl, C6-C14aralkenyl and C3-C13heteroaralkenyl; n is 0 or 1; L1 is tertiary phosphine; and L2 is a neutral e− donor ligand which is coordinated to the metal atom and is attached via the bridge group C* to the carbon atom of the carbene group if n is 0 and to Y if n is 1.Type: GrantFiled: December 16, 1999Date of Patent: October 23, 2001Assignee: Ciba Specialty Chemicals CorporationInventors: Paul Adriaan Van Der Schaaf, Andreas Hafner, Andreas Mühlebach
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Patent number: 6281307Abstract: Composition comprising (a) catalytic amounts of a one-component catalyst for metathesis polymerization and (b) at least one polymer with strained cycloalkenylene radicals bonded in the polymer backbone, alone or as a mixture with strained cycloolefins. The composition can be polymerized thermally or photochemically by metathesis polymerization and is suitable for the production of shaped articles, coatings and relief images. The catalyst is selected from Ruthenium and Osmium compounds.Type: GrantFiled: July 31, 1997Date of Patent: August 28, 2001Assignee: Ciba Specialty Chemicals CorporationInventors: Andreas Mühlebach, Andreas Hafner, Paul Adriaan Van Der Schaaf
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Patent number: 6277935Abstract: A solventless polymerizable composition comprising (a) at least one strained cycloolefin that is liquid or is meltable without decomposition, and (b) a catalytic amount of at least one compound of formula I or Ia or a mixture of compounds of formula I and Ia wherein Me is ruthenium or osmium; T1 and T2 are each independently of the other a tertiary phosphine or T1 and T2 together form a ditertiary diphosphine; T3 is hydrogen, C1-C12alkyl; C3-C8cycloalkyl, C3-C7heterocycloalkyl having one or two hetero atoms selected from the group —O—, —S— and —N—, C6-C14aryl, or C4-C15heteroaryl having from one to three hetero atoms selected from the group —O—, —S— and —N—, which are unsubstituted or substituted by C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy, C6-C10aryl, C6-C10aryloxy, —NO2 or by halogen; T4 is C6-C16arene or C4-C15heteroarene each of which is unsubstituted or substituted by from one to three C1-C4alkyl, C1-C4haType: GrantFiled: April 13, 1998Date of Patent: August 21, 2001Assignee: Ciba Specialty Chemicals CorporationInventors: Andreas Hafner, Paul Adriaan Van Der Schaaf, Andreas Mühlebach
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Patent number: 6235856Abstract: Composition of (a) dicyclopentadiene, by itself or in a mixture with a strained cycloolefin, and (b) a catalytic amount of at least one carbene-free, divalent-cationic ruthenium or osmium compound as a single-component catalyst, which contains at least one phosphine group and a total of 2 to 5 ligands bonded to the metal atom, and which contains acid anions for charge balancing. The compositions can be polymerized by means of heat (metathesis polymerization) and are suitable for the production of shaped articles and coatings.Type: GrantFiled: June 19, 1997Date of Patent: May 22, 2001Assignee: Ciba Specialty Chemicals CorporationInventors: Andreas Hafner, Paul Adriaan Van Der Schaaf, Andreas Mühlebach
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Patent number: 6204347Abstract: A catalyst system for the ring-opening metathesis polymerization, which consists of at least two components (a) and (b), wherein (a) is a ruthenium compound of formula I or II RuX2(L1)m(L2)n(L3)o(L4)p (I), ARuX2(L1)r(L2)s (II), wherein L1, L2, L3 and L4 are each independently of the other C1-C18alkylcyanide, C8-C24-aralkylcyanide, tertiary amine, tertiary phosphine which does not contain any secondary alkyl or cycloalkyl radicals bound to the phosphorus atom, or phosphite, X is halogen, A is arene, m, n, o and p are integers from 0 to 4, where 2≦m+n+o+p≦4, r and s are integers from 0 to 2, where 1≦r+s≦2, and (b) is a tertiary phosphine containing at least one secondary alkyl radical or cycloalkyl radical bound to the phosphorus atom, is particularly suitable for the polymerization of strained cycloolefins by the RIM process.Type: GrantFiled: August 18, 1999Date of Patent: March 20, 2001Assignee: Ciba Specialty Chemicals CorporationInventors: Andreas Hafner, Paul Adriaan Van Der Schaaf, Andreas Mühlebach
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Patent number: 6171995Abstract: A composition, comprising (a) a compound of formula I (R1R2R3P)xLyM2+Z1−Z2− (I), wherein R1, R2 and R3 are each independently of one another H, C1-C20alkyl, C1-C20-alkoxy; C4-C12cycloalkyl which is unsubstituted or substituted by C1-C6-alkyl, C1-C6haloalkyl or C1-C6alkoxy; C4-C12cycloalkoxy which is unsubstituted or substituted by C1-C6-alkyl, C1-C6haloalkyl or C1-C6alkoxy; C6-C16aryl which is unsubstituted or substituted by C1-C6alkyl, C1-C6haloalkyl or C1-C6alkoxy; C6-Cl6aryloxy which is unsubstituted or substituted by C1-C6alkyl, C1-C6haloalkyl or C1-C6alkoxy; C7-C16-aralkyloxy which is unsubstituted or substituted by C1-C6alkyl, C1-C6haloalkyl or C1-C6alkoxy; or C7-C16aralkyloxy which is unsubstituted or substituted by C1-C6alkyl, C1-C6-haloalkyl or C1-C6alkoxy; or R2 and R3 together are tetra- or pentamethylene which is unsubstituted or substituted by C1-C6alkyl, C1-C6haloalkyl or C1-C6alkoxy; tetra- or pentamethylenedioxyl which is unsubstituted or substituted by C1-C6alType: GrantFiled: November 14, 1997Date of Patent: January 9, 2001Assignee: Ciba Specialty Chemcials CorporationInventors: Andreas M{umlaut over (u)}hlebach, Paul Adriaan Van Der Schaaf, Andreas Hafner
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Patent number: 6162883Abstract: A mixture of at least one thermal carbene-free ruthenium catalyst A and at least one thermal ruthenium carbene catalyst B, both of which initiate the ring-opening metathesis polymerization on their own, said catalysts being present in a weight ratio of A to B from 10:1 to 1:10. By adding this mixture even in small amounts, the ring-opening metathesis polymerization of strained cycloolefins can be effectively catalyzed.Type: GrantFiled: September 30, 1998Date of Patent: December 19, 2000Assignee: Ciba Specialty Chemcials CorporationInventors: Andreas Muhlebach, Paul Adriaan Van Der Schaaf, Andreas Hafner
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Patent number: 6093779Abstract: Compositions comprising at least one nonvolatile acetylene alone or together with a strained cycloolefin and catalytic amounts of a catalyst for metathesis polymerization, which comprise at least one one-component catalyst from the group molybdenum compounds, tungsten compounds, niobium compounds and tantalum compounds which comprise (a) either at least two methyl groups or two monosubstituted methyl groups without .alpha. hydrogen atoms in the substituent or (b) at least one halogen and only one silylmethyl group attached to the metal. The storage-stable compositions can be polymerized by the action of actinic radiation or by short-term irradiation and subsequent thermal curing. The polymers can be used to prepare shaped articles, films, coatings and relief images.Type: GrantFiled: June 16, 1997Date of Patent: July 25, 2000Assignee: Ciba Specialty Chemicals CorporationInventors: Paul Adriaan Van Der Schaaf, Andreas Hafner, Andreas Muhlebach
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Patent number: 6077805Abstract: Hexacoordinated ruthenium and osmium catalysts of the formulae ##STR1## in which M and M' independently of one another are ruthenium or osmium;X, X', Y and Y' independently of one another are anionic ligands, or X and Y and X' and Y' in each case together are bis-anionic ligandsL.sup.1 and L.sup.1' independently of one another are tertiary phosphine;L.sup.2 and L.sup.3 independently of one another are a monodentate ligand, or L.sup.2 and L.sup.3 together are bidentate, neutral electron donor ligands;L.sup.4 is tetradentate, neutral electron donor ligand;L.sup.5 is a bidentate, neutral electron donor ligand; andT and T' indepedently of one another are H or organic substituents, are useful for the synthesis of custom-tailored polymers and for the ring-closing metathesis of olefins.Type: GrantFiled: March 2, 1998Date of Patent: June 20, 2000Assignee: Ciba Specialty Chemicals CorporationInventors: Paul Adriaan Van Der Schaaf, Andreas Hafner, Andreas Muhlebach
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Patent number: 6008306Abstract: Composition of (a) at least one strained cycloolefin and (b) a catalytic quantity of at least one divalent-cationic compound of ruthenium or osmium with a metal atom, to which are bound 1 to 3 tertiary phosphine ligands with, in the case of the ruthenium compounds, sterically exacting substituents, optionally non-photolabile neutral ligands and anions for charge balancing, with the proviso that in ruthenium (trisphenylphosphine)dihalides or hydride-halides the phenyl groups are substituted by C.sub.1 -C.sub.18 alkyl, C.sub.1 -C.sub.18 haloalkyl or C.sub.1 -C.sub.18 alkoxy. The composition is suitable for the production of molded parts of all kinds and of coatings.Type: GrantFiled: May 14, 1997Date of Patent: December 28, 1999Assignee: Ciba Specialty Chemicals CorporationInventors: Andreas Hafner, Paul Adriaan Van Der Schaaf, Andreas Muhlebach
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Patent number: 5998326Abstract: A catalyst system for the ring-opening matathesis polymerization, which consists of at least two components (a) and (b), wherein(a) is a ruthenium compound of formula I or IIRuX.sub.2 (L.sub.1).sub.m (L.sub.2).sub.n (L.sub.3).sub.o (L.sub.4).sub.p (I),ARuX.sub.2 (L.sub.1).sub.r L.sub.2).sub.3 (II),wherein L.sub.1,L.sub.2, L.sub.3 and L.sub.4 are each independently of the other C.sub.1 -C.sub.18 alkylcyanide, C.sub.6 -C.sub.24 - aralkylcyanide, tertiary amine, tertiary phosphine which does not contain any secondary alkyl or cycloalkyl radicals bound to the phosphorus atom, or phosphite, X is halogen, A is arene, m, n, o and p are integers from 0 to 4, where 2.ltoreq.m+n+o+p.ltoreq.4, r and s are integers from 0 to 2, where 1.ltoreq.r+s.ltoreq.2, and(b) is a tertiary phosphine containing at least one secondary alkyl radical or cycloalkyl radical bound to the phosphorus atom,is particularly suitable for the polymerisation of strained cycloolefins by the RIM process.Type: GrantFiled: May 11, 1998Date of Patent: December 7, 1999Assignee: Ciba Specialty Chemicals Corp.Inventors: Andreas Hafner, Paul Adriaan Van Der Schaaf, Andreas Muhlebach
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Patent number: 5973085Abstract: Compounds of the formula I(A).sub.n --B (I)in which A is the radical of a strained cycloolefin, B is a direct bond or an n-valent bridging group and n is an integer from 2 to 8, with the exception of 1,2-bisnorbornenyl-ethane and norbornenecarboxylic acid norbornenemethyl ester. The compounds of the formula I can be polymerized with one-component catalysts (ring-opening metathesis polymerization).Type: GrantFiled: May 14, 1997Date of Patent: October 26, 1999Assignee: Ciba Specialty Chemicals CorporationInventors: Andreas Muhlebach, Andreas Hafner, Paul Adriaan Van Der Schaaf