Patents by Inventor Paul Alexandre DeSousa

Paul Alexandre DeSousa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cloning method using oocytes matured in vivo
    Publication number: 20040083498
    Abstract: A method is described of selecting a porcine oocyte or a population of oocytes with improved developmental competence following either in vitro or in vivo maturation.
    Type: Application
    Filed: April 14, 2003
    Publication date: April 29, 2004
    Inventors: Paul Alexandre DeSousa, Timothy James King, Ian Wilmut, Jie Zhu
  • Developmental competence for assisted reproduction and nuclear transfer in pigs
    Patent number: 6548741
    Abstract: An optimum time has been discovered for obtaining porcine oocytes with improved developmental competence. Harvested oocytes are matured by culturing in vitro, and then activated ˜42-46 hours after beginning of the culture period. Alternatively, ovulation is induced in a donor female using a gonadotrophic hormone (optionally monitored by ultrasonography), maturation is allowed to proceed in vivo, and then the harvested oocyte is activated ˜44-48 hours after inducing ovulation. Outside the optimal time frame, the ability of the oocytes to undergo parthenogenetic activation declines markedly. These methods overcome problems encountered with previous protocols for nuclear transfer and assisted reproduction in the pig.
    Type: Grant
    Filed: April 9, 2001
    Date of Patent: April 15, 2003
    Assignee: Geron Corporation
    Inventors: Paul Alexandre DeSousa, Timothy James King, Ian Wilmut, Jie Zhu
  • Developmental competence for assisted reproduction and nuclear transfer in pigs
    Publication number: 20010049829
    Abstract: A method is described of selecting a porcine oocyte or a population of oocytes with improved developmental competence following either in vitro or in vivo maturation.
    Type: Application
    Filed: April 9, 2001
    Publication date: December 6, 2001
    Inventors: Paul Alexandre DeSousa, Timothy James King, Ian Wilmut, Jie Zhu