Abstract: A method of accelerating cellular maturation is provided, the method including impairing the activity of developmental transcriptional condensates at an intermediate stage of a cell lineage. Specifically, Sox6 gene expression is inhibited to accelerate maturation of oligodendrocyte precursors, such as oligodrendrocyte progenitor cells (OPCs), into fully mature myelin-producing oligodendrocytes.

Abstract: In one example in accordance with the present disclosure, a method is described. According to the method, a pump is selectively activated to draw print fluid from a print fluid delivery system towards a reclamation container. It is detected when a reservoir of the print fluid delivery system is empty. In response to an indication that the reservoir is empty, the pump is selectively deactivated to terminate a print fluid reclamation process.

Abstract: A downhole tool assembly is configured for repeated and selective hydraulic activation and deactivation. A spring member biases the indexing control section 210 towards a first axial position while drilling fluid pressure in the tool body urges the indexing control section 210 towards other axial positions. Downhole tool activation and deactivation may repeatedly be controlled from the surface by cycling the drilling fluid pressure.

Abstract: Various embodiments may provide systems and methods for determining a distance to a short in a two-conductor wire. Various embodiments may include determining a distance to a short in a two-conductor wire based at least in part on a phase difference between a phase of an injected tone and a phase of a reflected tone. Various embodiments may include determining a distance to a short in a two-conductor wire based at least in part on both a phase difference and an amplitude difference between an injected tone and a reflected tone. Various embodiments may include determining a distance to a short in a two-conductor wire based at least in part on a measured peak voltage of a combined pulse.

Abstract: The present patent application discloses the compounds according to Formula I shown below, or pharmaceutically acceptable salts thereof, wherein JB, n, R1, R2, R3, R4, R5, m and X as defined herein.

Abstract: Systems are provided for an imaging system isolation enclosure for use with a medical imaging system includes a pathogen impermeable enclosure for use with one or more of radiation imaging systems and magnetic resonance imaging systems, the pathogen impermeable enclosure is configured to provide a barrier between the imaging system and at least one of a patient user and an imaging room, and an air filtration system including an inlet to supply a cooling air flow to an interior of the imaging system isolation enclosure and an outlet to output exhaust air from an interior of the imaging system isolation enclosure.

Abstract: An accessory device for use with a medical device includes a first cuff secured to a distal end of the medical device, a second cuff secured to the medical device proximal of the first cuff, an actuator, and at least one actuation wire extending from the first cuff, through the second cuff, to the actuator.

Abstract: A method of pumping an oilfield fluid from a well surface to a wellbore is provided that includes providing a clean stream; operating one or more clean pumps to pump the clean stream from the well surface to the wellbore; providing a dirty stream including a solid material disposed in a fluid carrier; and operating one or more dirty pumps to pump the dirty stream from the well surface to the wellbore, wherein the clean stream and the dirty stream together form said oilfield fluid.

Abstract: In flow cytometry, particles (2) can be distinguished between populations (8) by combining n-dimensional parameter data, which may be derived from signal data from a particle, to mathematically achieve numerical results representative of an alteration (48). An alteration may include a rotational alteration, a scaled alteration, or perhaps even a translational alteration. Alterations may enhance separation of data points which may provide real-time classification (49) of signal data corresponding to individual particles into one of at least two populations.

Abstract: The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutically acceptable salts, pharmaceutical formulations comprising them as well as their phosphate ester prodrugs, and their uses alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) and/or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or the upregulation of the NO pathway is desirable. The compounds are of Formula I.

Abstract: In one example in accordance with the present disclosure, a method is described. According to the method, a pump is selectively activated to draw print fluid from a print fluid delivery system towards a reclamation container. It is detected when a reservoir of the print fluid delivery system is empty. In response to an indication that the reservoir is empty, the pump is selectively deactivated to terminate a print fluid reclamation process.

Abstract: A method of determining a position of a target using a metric comprises receiving a plurality of ultrasound signals representative of ultrasound energy received from the target and, for each of a plurality of different foci, adjusting the ultrasound signals in dependence on the focus and determining a value of the metric using the adjusted ultrasound signals. The method further comprises using the determined values for the metric for the different foci to determine a position of the target.

Abstract: The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or an upregulation of the NO pathway is desirable.

Abstract: A print liquid supply apparatus or interface structure to be connected to a print system comprises a liquid channel, liquid interface and integrated circuit contact pads.

Abstract: A print liquid supply apparatus or interface structure to be connected to a print system comprises a liquid channel, liquid interface and integrated circuit contact pads.

Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

Abstract: According to examples, an apparatus may include a chassis having an interior region and a first printing fluid reservoir arranged within the interior region of the chassis. The chassis may fix the first printing fluid reservoir relative to a second printing fluid reservoir. The apparatus may also include a bottle seat that may define a charging port in fluidic communication to the first printing fluid reservoir to convey refill printing fluid received at the charging port to the first printing fluid reservoir. A fluidic interface may be arranged on the chassis and fluidically coupled to the first printing fluid reservoir to convey the printing fluid outside the chassis to a print head.

Abstract: In some examples a printing system includes purging manifolds. The printing system includes a fluid ejection device to dispense a fluid and a first reservoir to house a fluid. The system further includes a purging manifold to fluidically couple to the fluid ejection device, and the purging manifold to fluidically couple to the first reservoir. The purging manifold includes a second reservoir. The purging manifold further includes a supply port; a fluid inlet port; and a purging outlet port. The purging outlet port is disposed above the supply port to convey fluid to the first reservoir. The printing system also includes a fluid interface connector to fluidically connect to the supply port and fluidically connect to the fluid ejection device.

Abstract: In one example in accordance with the present disclosure, a print fluid delivery system is described. The print fluid delivery system includes a main reservoir to hold a volume of print fluid to be supplied to a printhead and a fluid indicator reservoir fluidly coupled to the main reservoir. The fluid indicator reservoir visually indicates a fluid level through an aperture in a printing system housing. The fluid indicator reservoir and the main reservoir have a same fluid level. The print fluid delivery system also includes a fluid transport system to transport fluid through the print fluid delivery system.

Abstract: In one example in accordance with the present disclosure, a print fluid refill system is described. The print fluid refill system includes a reservoir to hold a volume of print fluid to be supplied to a printhead. The print fluid refill system also includes a pump to 1 ) draw print fluid from the reservoir via a reservoir line and 2) transport print fluid to a reserve tank via a reserve line. The print fluid refill system also includes the reserve tank to, during refill of the reservoir, supply print fluid to a printhead via a printhead line. The reserve tank supplies print fluid to the printhead when fluid is passed to the reservoir via a return line.