Patents by Inventor Paul Allen Bethel

Paul Allen Bethel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESSES FOR THE PREPARATION OF 4-{8-AMINO-3-[(2S)-1-(BUT-2-YNOYL)-PYRROLIDIN-2-YL]IMIDAZO[1,5-a]-PYRAZIN-1-YL}N-(PYRIDIN-2-YL)-BENZAMIDE
    Publication number: 20220127270
    Abstract: The present disclosure relates, in general, to improved processes for the preparation of 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)-benzamide, particularly large-scale processes for manufacturing 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)benzamide and intermediates used in such processes.
    Type: Application
    Filed: August 28, 2019
    Publication date: April 28, 2022
    Inventors: Paul Allen BETHEL, Lai Chun CHAN, Katie Grace COOPER, Robert John COX, Michael David GOLDEN, Shaun Alan HUGHES, Lucinda Victoria JACKSON, Kirsty Jane MILLARD, Andrew John PHILLIPS, Alexander James TELFORD, Jerry EVARTS, Michael Joseph LAWLER, Remy E. J. N. LITJENS, Peter Johannes Servaas Savio VAN EIJK, Mathilda Maria Henrica VERSTAPPEN, Frank L. M. VOS, Eric Jurriën ZIJP, Qiu JUNYING, Rustam Ferdinand GARREY, David Allen SHORT, Angang WANG
  • CRYSTALLINE FORM
    Publication number: 20190100498
    Abstract: The application relates to a crystalline form of the compound of formula (I).
    Type: Application
    Filed: March 24, 2016
    Publication date: April 4, 2019
    Inventors: Thomas LANGER, Paul Allen BETHEL, Mohammed PERVEZ, Lai Chun CHAN, Sophie JANBON
  • Amide derivatives
    Patent number: 7786115
    Abstract: The invention concerns a compound of the Formula I wherein m is 0-2 and each R1 is a group such as hydroxy, halogeno, trifluoromethyl heterocyclyl and heterocyclyloxy; R2 is halogeno, trifluoromethyl or (1-6C)alkyl; R3 is hydrogen, halogeno or (1-6C)alkyl; and R4 is (3-6C)cycloalkyl;or pharmaceutically-acceptable salts thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: August 31, 2010
    Assignee: AstraZeneca AB
    Inventors: Ian Alun Nash, Kenneth Mark Page, Paul Allen Bethel
  • Amide Derivatives
    Publication number: 20080146566
    Abstract: The invention concerns a compound of the Formula I (A chemical formula should be inserted here—please see paper copy enclosed herewith) wherein m is 0-2 and each R1 is a group such as hydroxy, halogeno, trifluoromethyl heterocyclyl and heterocyclyloxy; R2 is halogeno, trifluoromethyl or (1-6C)alkyl; R3 is hydrogen, halogeno or (1-6C)alkyl; and R4 is (3-6C)cycloalkyl; or pharmaceutically-acceptable salts thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.
    Type: Application
    Filed: December 22, 2005
    Publication date: June 19, 2008
    Inventors: Ian Alun Nash, Kenneth Mark Page, Paul Allen Bethel